Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Steven W. Matson"'
Autor:
Robert M. Brosh, Steven W. Matson
Publikováno v:
Genes
Genes, Vol 11, Iss 3, p 255 (2020)
Genes, Vol 11, Iss 3, p 255 (2020)
Since the discovery of the DNA double helix, there has been a fascination in understanding the molecular mechanisms and cellular processes that account for: (i) the transmission of genetic information from one generation to the next and (ii) the rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a21f62ad3ba363f3664260b24bf164
https://doi.org/10.3390/genes11030255
https://doi.org/10.3390/genes11030255
Autor:
Robert M. Brosh, Steven W. Matson
The checkpoint kinase Rad53 is activated during replication stress to prevent fork collapse, an essential but poorly understood process. Here we show that Rad53 couples leading- and lagging-strand synthesis under replication stress. In rad53-1 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e3f6dc36e8733a41bfcb33f9a5a5dd
https://europepmc.org/articles/PMC5914726/
https://europepmc.org/articles/PMC5914726/
Publikováno v:
Journal of Biological Chemistry. 289:17100-17110
DNA helicases use energy derived from nucleoside 5'-triphosphate hydrolysis to catalyze the separation of double-stranded DNA into single-stranded intermediates for replication, recombination, and repair. Escherichia coli helicase II (UvrD) functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c429e2e7657e0730799bffbab04309dd
https://doi.org/10.1074/jbc.m114.565309
https://doi.org/10.1074/jbc.m114.565309
Repair of DNA damage is essential to the preservation of genomic stability. During repair of double-strand breaks, several helicases function to promote accurate repair and prevent the formation of crossovers through homologous recombination. Among t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0051c533a6fb80189735374019e6a13
https://europepmc.org/articles/PMC5068844/
https://europepmc.org/articles/PMC5068844/
Publikováno v:
Journal of Biological Chemistry. 281:36110-36116
The F plasmid TraI protein (DNA helicase I) plays an essential role in conjugative DNA transfer as both a transesterase and a helicase. Previous work has shown that the 192-kDa TraI protein is a highly processive helicase, catalytically separating >8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d211022008767efc6fc3a2c201ea38
https://doi.org/10.1074/jbc.m604412200
https://doi.org/10.1074/jbc.m604412200
Publikováno v:
Journal of Molecular Biology. 362:18-25
Many studies have demonstrated the need for processing of blocked replication forks to underpin genome duplication. UvrD helicase in Escherichia coli has been implicated in the processing of damaged replication forks, or the recombination intermediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ddbd6606fdb6cb73b77d480e9aa81bb
https://doi.org/10.1016/j.jmb.2006.06.032
https://doi.org/10.1016/j.jmb.2006.06.032
The DNA Binding Activity of MutL Is Required for Methyl-directed Mismatch Repair in Escherichia coli
Publikováno v:
Journal of Biological Chemistry. 281:8399-8408
The DNA binding properties of the mismatch repair protein MutL and their importance in the repair process have been controversial for nearly two decades. We have addressed this issue using a point mutant of MutL (MutL-R266E). The biochemical and gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1bc1fe67482d33b334101e7c55cbab8
https://doi.org/10.1074/jbc.m509184200
https://doi.org/10.1074/jbc.m509184200
Publikováno v:
Yeast. 22:1269-1286
The HMI1 gene encodes a DNA helicase that localizes to the mitochondria and is required for maintenance of the mitochondrial DNA (mtDNA) genome of Saccharomyces cerevisiae. Identified based on its homology with E. coli uvrD, the HMI1 gene product, Hm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f918d80a287fe2028d63d85211f8348
https://doi.org/10.1002/yea.1313
https://doi.org/10.1002/yea.1313
Publikováno v:
Journal of Biological Chemistry. 276:2372-2379
The product of the Escherichia coli F plasmid traI gene is required for DNA transfer via bacterial conjugation. This bifunctional protein catalyzes the unwinding of duplex DNA and is a sequence-specific DNA transesterase. The latter activity provides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83b4ac39b73468def670cef77b028ddc
https://doi.org/10.1074/jbc.m008728200
https://doi.org/10.1074/jbc.m008728200
Publikováno v:
Journal of Bacteriology. 181:2519-2526
DNA helicase-catalyzed unwinding of duplex DNA provides the single-stranded DNA (ssDNA) intermediates required for the reactions of DNA metabolism, including DNA replication, recombination, transcription, bacterial conjugation, and DNA repair (25, 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9fa7b08ee89bfd080910523cf608262
https://doi.org/10.1128/jb.181.8.2519-2526.1999
https://doi.org/10.1128/jb.181.8.2519-2526.1999