Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Steven W. Kramer"'
Autor:
Albert E. Schmelzer, Mark G. Currie, Kam F. Fok, Pamela T. Manning, William M. Moore, Gina M. Jerome, Timothy J. Hagen, Arija A. Bergmanis, Barnett S. Pitzele, Linda F. Branson, Steven W. Kramer, E. Ann Hallinan, Christine Kornmeier, Lydia Swenton, Jane R. Connor
Publikováno v:
Journal of Medicinal Chemistry. 41:3675-3683
A series of substituted 2-iminopyrrolidines has been prepared and shown to be potent and selective inhibitors of the human inducible nitric oxide synthase (hiNOS) isoform versus the human endothelial nitric oxide synthase (heNOS) and the human neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74f1de3e2f9933df0d68a6b9e2b8d4d
https://doi.org/10.1021/jm970840x
https://doi.org/10.1021/jm970840x
Autor:
Mark G. Currie, Karen B. Peterson, William M. Moore, Pamela T. Manning, Thomas P. Misko, Christine M. Kornmeier, Steven W. Kramer, Jane R. Connor, Gina M. Jerome, Barnett S. Pitzele, Mahima Trivedi, Foe S. Tjoeng, Donald W. Hansen, Ronald Keith Webber
Publikováno v:
Journal of Medicinal Chemistry. 41:1361-1366
An attractive approach to the treatment of inflammatory conditions such as osteo- and rheumatoid arthritis, inflammatory bowel disease, and sepsis is through the selective inhibition of human inducible nitric oxide synthase (hiNOS) since localized ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681bd0252c2170629f7f44f4fd7f776a
https://doi.org/10.1021/jm9704715
https://doi.org/10.1021/jm9704715
Autor:
Len F. Lee, Steven W. Kramer, A. W. Veenhuizen, Carol M. Koboldt, Paul W. Collins, Yan Y. Zhang, Peter C. Isakson, Karen Seibert, Thomas D. Penning
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2121-2124
A series of 3,4-diarylpyrazoles was synthesized and evaluated for their ability to selectively inhibit cyclooxygenase-2 (COX-2). A number of potent and selective inhibitors were identified and found to have oral anti-inflammatory activity in a rat ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::479d32fe6815640e8bcff985c1ac75d3
https://doi.org/10.1016/s0960-894x(97)00372-7
https://doi.org/10.1016/s0960-894x(97)00372-7
Autor:
Graneto Matthew J, Donald J. Rogier, Yan Zhang, William E. Perkins, John J. Talley, Roland S. Rogers, Steven W. Kramer, A. W. Veenhuizen, Stephen R. Bertenshaw, Carol M. Koboldt, T. D. Penning
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2919-2922
A group of 3,4-diarylthiophenes containing either a sulfone or sulfonamide moiety were synthesized and tested for COX-1 and COX-2 inhibition. They are selective inhibitors of COX-2 and possess antiinflammatory activity in vivo .
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::189fba94d4e196cef742bcb6f517780b
https://doi.org/10.1016/0960-894x(95)00512-r
https://doi.org/10.1016/0960-894x(95)00512-r
Autor:
Steven W. Kramer, Paul W. Collins, Kevin A. Babiak, V. J. Kalish, Robert L. Shone, Mclaughlin Kathleen T, John S. Ng
Publikováno v:
ChemInform. 22
Hydrozirconation-iodination of a terminal acetylene followed by lithium-iodide exchange and finally dilithio cyanocuprate mediated conjugate addition to an appropriate cyclopentenone is reported as an efficient method for the synthesis of prostagland
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::572736a7e4d75381bcb0438d28fb28cf
https://doi.org/10.1002/chin.199105309
https://doi.org/10.1002/chin.199105309
Autor:
Kevin A. Babiak, Vincent J. Kalish, Robert L. Shone, John H. Dygos, Mclaughlin Kathleen T, James R. Behling, John S. Ng, Steven W. Kramer
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b3077f274ffe1c7b1a2c4e0ac628496
https://doi.org/10.1002/chin.199103338
https://doi.org/10.1002/chin.199103338
Autor:
Graneto Matthew J, T. D. Penning, John J. Talley, Stephen R. Bertenshaw, Yan Zhang, Roland S. Rogers, Steven W. Kramer, William E. Perkins, Donald J. Rogier, A. W. Veenhuizen, Carol M. Koboldt
Publikováno v:
ChemInform. 27
A group of 3,4-diarylthiophenes containing either a sulfone or sulfonamide moiety were synthesized and tested for COX-1 and COX-2 inhibition. They are selective inhibitors of COX-2 and possess antiinflammatory activity in vivo .
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05992358ec12912c7e8037ad6edc24dc
https://doi.org/10.1002/chin.199614123
https://doi.org/10.1002/chin.199614123
Autor:
R. G. Bianchi, Steven W. Kramer, W E Perkins, Alan F. Gasiecki, P. W. Collins, Robert L. Shone
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1761-1766
The synthesis of a 16-fluoromethyl analog of SC-46275, a potent, long-acting and selective analog of enisoprost, is described. Introduction of a fluorine atom to the C-16 methyl group of SC-46275 conveys a remarkable increase in stability toward acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e0c75935585e6510268828a5f537311
https://doi.org/10.1016/s0960-894x(00)80471-0
https://doi.org/10.1016/s0960-894x(00)80471-0
Autor:
Steven W. Kramer, R. G. Bianchi, P. W. Collins, Peter H. Jones, E E Yonan, W E Perkins, Gary W. Gullikson, Alan F. Gasiecki, John S. Ng, L Swenton
Publikováno v:
Journal of Medicinal Chemistry. 33:2784-2793
A series of delta 17 unsaturated cycloalkyl and cycloalkenyl analogues of enisoprost was synthesized to investigate the effects of omega chain unsaturation on gastric antisecretory activity and diarrheogenic side effects. Of these, the 17E, 18-cyclop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efbad9c3e968e279a7b9a2f08070e682
https://doi.org/10.1021/jm00172a017
https://doi.org/10.1021/jm00172a017
Autor:
V. J. Kalish, John S. Ng, Steven W. Kramer, Paul W. Collins, Robert L. Shone, Mclaughlin Kathleen T, Kevin A. Babiak
Publikováno v:
Synthetic Communications. 20:1641-1645
Hydrozirconation-iodination of a terminal acetylene followed by lithium-iodide exchange and finally dilithio cyanocuprate mediated conjugate addition to an appropriate cyclopentenone is reported as an efficient method for the synthesis of prostagland
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0030c25f7d3d993d30ef3782162cebd
https://doi.org/10.1080/00397919008053084
https://doi.org/10.1080/00397919008053084