Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Steven W. Kortum"'
Autor:
Alexander Gontcharov, Peter Jones, Steven W. Kortum, David Pattavina, Seungwon Chung, Peter Robert Rose, Jotham Wadsworth Coe, Tim L. Houck, Javier Magano, Lacey Samp, Anil Rane
Publikováno v:
Organic Process Research & Development. 23:1990-2000
A scalable synthesis of a pan-JAK inhibitor is described. The original synthesis by the Medicinal Chemistry group has been modified to develop a new protecting group strategy, a 3-step telescoped s...
Autor:
Hayat K. Rahman, Tenbrink Ruth E, Barbara A. Schweitzer, Rita M. Huff, Steven W. Kortum, Gopichand Yalamanchili, Rhonda M. Lachance, Ennis Michael D
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5919-5923
Herein we describe the design and synthesis of a novel series of potent thienopyrimidine P2Y12 inhibitors and the negative impact protein binding has on the inhibition of platelet aggregation.
Autor:
Timothy E. Benson, Michael J. Bienkowski, Tenbrink Ruth E, Alice Laborde, D. Bryan Prince, Joseph B. Moon, Steven W. Kortum, Thomas L. Emmons, Alfredo G. Tomasselli, Donna J. Paddock
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3378-3383
The design and synthesis of a novel series of potent BACE1 hydroxyethylamine inhibitors. These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D.