Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Steven W. Elmore"'
Autor:
Darren C. Phillips, Joel D. Leverson, Andrew J. Souers, Steven W. Elmore, William N. Pappano, Lisa Roberts-Rapp, Xin Lu, Paul Hessler, Milan Bruncko, George S. Sheppard, Paul Nimmer, Yu Xiao
Supplemental Figure 2: The susceptibility of breast cancer cell lines to MCL-1 siRNA according to genotype and expression of BCL-2 family members.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698cc98368485a4cf5a4ddd38b33f7ba
https://doi.org/10.1158/1535-7163.22501659
https://doi.org/10.1158/1535-7163.22501659
Autor:
Andrew J. Souers, Nathaniel D. Catron, Geoff G.Z. Zhang, Xilu Wang, Ahmed A. Suleiman, Deanne Stolarik, Yi Shi, Ahmad Y. Sheikh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Yu-Ming Pu, Darren C. Phillips, Chang H. Park, Rajeev M. Menon, Kennan C. Marsh, Richard A. Marks, Joel D. Leverson, Yi-Yin Ku, Russell C. Klix, John C. Kalvass, Russell A. Judge, Jianguo Ji, Gary J. Jenkins, Richard Hong, Kaid C. Harper, Keith M. Fournier, Steven W. Elmore, Rohinton Edalji, Shuang Chen, Jie Chen, Orlando F. Bueno, Zhi-Fu Tao, Ahmed Hamed Salem
Since gaining approval for the treatment of chronic lymphocytic leukemia (CLL), the BCL-2 inhibitor venetoclax has transformed the treatment of this and other blood-related cancers. Reflecting the large and hydrophobic BH3-binding groove within BCL-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f852ee29a9488942fba6fce73ac0eaf
https://doi.org/10.1158/1535-7163.c.6543327.v1
https://doi.org/10.1158/1535-7163.c.6543327.v1
Autor:
Andrew J. Souers, Nathaniel D. Catron, Geoff G.Z. Zhang, Xilu Wang, Ahmed A. Suleiman, Deanne Stolarik, Yi Shi, Ahmad Y. Sheikh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Yu-Ming Pu, Darren C. Phillips, Chang H. Park, Rajeev M. Menon, Kennan C. Marsh, Richard A. Marks, Joel D. Leverson, Yi-Yin Ku, Russell C. Klix, John C. Kalvass, Russell A. Judge, Jianguo Ji, Gary J. Jenkins, Richard Hong, Kaid C. Harper, Keith M. Fournier, Steven W. Elmore, Rohinton Edalji, Shuang Chen, Jie Chen, Orlando F. Bueno, Zhi-Fu Tao, Ahmed Hamed Salem
1. Measured pKa values of ABBV-167 (Table S1. Ionization constants of ABBV-167) 2. Preparation of ABBV-167 on large scale (Scheme S1: Synopsis of GMP synthesis of ABBV-167) 3. Preparation of clinical ABBV-167 drug supply 4. Animal pharmacokinetics (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b82ad084c554229baf59a8bada6e495
https://doi.org/10.1158/1535-7163.22522290
https://doi.org/10.1158/1535-7163.22522290
Autor:
Darren C. Phillips, Joel D. Leverson, Andrew J. Souers, Steven W. Elmore, William N. Pappano, Lisa Roberts-Rapp, Xin Lu, Paul Hessler, Milan Bruncko, George S. Sheppard, Paul Nimmer, Yu Xiao
Supplemental Figure 3: MCL-1 dependency dictates cellular response to the CDK9 inhibitor flavopiridol and correlates with kinetics of death resulting from MCL-1 siRNA treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177c95a199ffdd6cfd18bc12327ac0f5
https://doi.org/10.1158/1535-7163.22501656.v1
https://doi.org/10.1158/1535-7163.22501656.v1
Autor:
Steven W. Elmore, Chris Tse, Joel D. Leverson, Deepak Sampath, Heather Maecker, Saul H. Rosenberg, Scott L. Ackler, Haichao Zhang, Stephen K. Tahir, Alexander R. Shoemaker, Yu Shen, Morey Smith, Xiaoyu Lin, Paul Nimmer, Michael J. Mitten, Bernard Liu, Xiaoli Huang, Vivek Abraham, Sha Jin, Jun Chen
PDF file - 40K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2c37b6b6dd801b591e2466ba9d48a4
https://doi.org/10.1158/1535-7163.22497208
https://doi.org/10.1158/1535-7163.22497208
Autor:
Darren C. Phillips, Joel D. Leverson, Andrew J. Souers, Steven W. Elmore, William N. Pappano, Lisa Roberts-Rapp, Xin Lu, Paul Hessler, Milan Bruncko, George S. Sheppard, Paul Nimmer, Yu Xiao
Supplemental Figure 4: BCL-XL but not BCL-2 gene silencing sensitize HCC-1806 cells to A-1210477-induced apoptosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fd678b4e862617129319239cedcfda
https://doi.org/10.1158/1535-7163.22501653
https://doi.org/10.1158/1535-7163.22501653
Autor:
Darren C. Phillips, Joel D. Leverson, Andrew J. Souers, Steven W. Elmore, William N. Pappano, Lisa Roberts-Rapp, Xin Lu, Paul Hessler, Milan Bruncko, George S. Sheppard, Paul Nimmer, Yu Xiao
List of Supplementary Figure Legends. Figure legend information.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866e8312dc8bd341b6745fa481fac8ca
https://doi.org/10.1158/1535-7163.22501665
https://doi.org/10.1158/1535-7163.22501665
Autor:
Darren C. Phillips, Joel D. Leverson, Andrew J. Souers, Steven W. Elmore, William N. Pappano, Lisa Roberts-Rapp, Xin Lu, Paul Hessler, Milan Bruncko, George S. Sheppard, Paul Nimmer, Yu Xiao
Supplemental Figure 5: Flavopiridol synergizes with navitoclax in breast cancer cell lines in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885c2fdb3dd263312f42878db4c1dee2
https://doi.org/10.1158/1535-7163.22501650.v1
https://doi.org/10.1158/1535-7163.22501650.v1
Autor:
Darren C. Phillips, Joel D. Leverson, Andrew J. Souers, Steven W. Elmore, William N. Pappano, Lisa Roberts-Rapp, Xin Lu, Paul Hessler, Milan Bruncko, George S. Sheppard, Paul Nimmer, Yu Xiao
Supplemental Table 1: Viability of breast cancer cell lines treated with PBS, scrambled siRNA (Sc; 20nMol) or MCL-1 siRNA (20nMol) for 72hrs compared to non-treated cells with associated genomic info.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a28b632d7ac78c4f037fe9c9398014
https://doi.org/10.1158/1535-7163.22501647
https://doi.org/10.1158/1535-7163.22501647
Autor:
Darren C. Phillips, Joel D. Leverson, Andrew J. Souers, Steven W. Elmore, William N. Pappano, Lisa Roberts-Rapp, Xin Lu, Paul Hessler, Milan Bruncko, George S. Sheppard, Paul Nimmer, Yu Xiao
Supplemental Figure 1: Validation of MCL-1 siRNA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b272f2198d8a0666ffc4c9978ba676d
https://doi.org/10.1158/1535-7163.22501662.v1
https://doi.org/10.1158/1535-7163.22501662.v1