Výsledky vyhledávání - "Steven W Kumpf"

Akademický článek

Comparison and cross-validation of long-read and short-read target-enrichment sequencing methods to assess AAV vector integration into host genome

Autor: Mark Sheehan, Steven W. Kumpf, Jessie Qian, David M. Rubitski, Elias Oziolor, Thomas A. Lanz

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101352- (2024)

Evaluation of host integration profiles by adeno-associated virus (AAV) is an important component of de-risking novel AAV gene therapies. Targeted enrichment sequencing (TES) is a cost-effective and comprehensive method for assessing integration. Mos

Externí odkaz: https://doaj.org/article/654cd3cfc1ad47d7988230718f57b959

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Akademický článek

Comparing molecular and computational approaches for detecting viral integration of AAV gene therapy constructs

Autor: Elias M. Oziolor, Steven W. Kumpf, Jessie Qian, Mark Gosink, Mark Sheehan, David M. Rubitski, Leah Newman, Laurence O. Whiteley, Thomas A. Lanz

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 395-405 (2023)

Many current gene therapy targets use recombinant adeno-associated virus (AAV). The majority of delivered AAV therapeutics persist as episomes, separate from host DNA, yet some viral DNA can integrate into host DNA in different proportions and at gen

Externí odkaz: https://doaj.org/article/408d92ef4a474a9ab96737ca95b99093

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Supplementary Data from Myocarditis in Cynomolgus Monkeys Following Treatment with Immune Checkpoint Inhibitors

Autor: Bernard S. Buetow, Magali Guffroy, Martin Finkelstein, Nasir K. Khan, Puja Sapra, Andrea T. Hooper, William A. Meier, Frank Barletta, Matthew Martin, Steven W. Kumpf, Sripad Ram, Allison Vitsky, Jonathan Golas, Marc D. Roy, Changhua Ji

Table S1. Mean ({plus minus}SD) Toxicokinetic Parameters for Ipilimumab and Novolumab in Cynomolgus Monkeys Table S2 - Differentially expressed genes in the heart of ipilimumab and nivolumab treated cynos (adjusted P-value {less than or equal to} 0.0

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3942b4f23d29af0107356ea8a8bc653c
https://doi.org/10.1158/1078-0432.22469919.v1

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Supplementary Figures from Myocarditis in Cynomolgus Monkeys Following Treatment with Immune Checkpoint Inhibitors

Supplemental Figure S1. Concentration versus time profiles of ipilimumab and nivolumab following four weekly intravenous dose administrations of 15 mg/kg or 20 mg/kg, respectively. Supplementary Figure S2. Hematoxylin and eosin stained sections of ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027a7f5962acdd0744c93d4421f906a4
https://doi.org/10.1158/1078-0432.22469916

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Data from Myocarditis in Cynomolgus Monkeys Following Treatment with Immune Checkpoint Inhibitors

Purpose:Immune checkpoint inhibitors (ICI) targeting PD1, PDL1, or CTLA4 are associated with immune-related adverse events (irAE) in multiple organ systems including myocarditis. The pathogenesis and early diagnostic markers for ICI-induced myocardit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5055934097852ef3af9d150157463861
https://doi.org/10.1158/1078-0432.c.6527388

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Inhibition of Acetyl-CoA Carboxylase Causes Malformations in Rats and Rabbits: Comparison of Mammalian Findings and Alternative Assays

Autor: William S. Nowland, Steven W. Kumpf, Trenton T. Ross, Christopher J. Bowman, Gregg D. Cappon, Donald S Stedman, Scott D Davenport, William P. Esler, Christine Stethem, Natasha R. Catlin, Elise M. Lewis, Sarah N. Campion

Publikováno v: Toxicological Sciences. 179:183-194

Acetyl-CoA carboxylase (ACC) is an enzyme within the de novo lipogenesis (DNL) pathway and plays a role in regulating lipid metabolism. Pharmacologic ACC inhibition has been an area of interest for multiple potential indications including oncology, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6d9eb6a77626c055c46264ceba500b
https://doi.org/10.1093/toxsci/kfaa169

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Biodistribution and Tolerability of AAV-PHP.B-CBh

Publikováno v: Human gene therapy. 33(3-4)

Recombinant adeno-associated viruses (AAVs) have emerged as promising vectors for human gene therapy, but some variants have induced severe toxicity in Rhesus monkeys and piglets following high-dose intravenous (IV) administration. To characterize bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::794cfa4b206b8704a968304aa634a197
https://pubmed.ncbi.nlm.nih.gov/34931542

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