Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Steven W, Levison"'
Autor:
Veera D'Mello, Malini Subramaniam, Aditya Paul Bhalla, Sherlyn Saavedra, Ofri Leiba, Steven W. Levison
Publikováno v:
Neurotrauma Reports, Vol 4, Iss 1, Pp 236-250 (2023)
Leukemia inhibitory factor (LIF) is a neuroprotective cytokine that is essential for appropriate glial responses, remyelination, and preservation of neuronal conductance after injury. The intranasal route for delivery of therapeutics to the central n
Externí odkaz:
https://doaj.org/article/a042fa0d481f46868faa609a92fb22d3
Publikováno v:
ASN Neuro, Vol 14 (2022)
At the turn of the 21st century studies of the cells that resided in the adult mammalian subventricular zone (SVZ) characterized the neural stem cells (NSCs) as a subtype of astrocyte. Over the ensuing years, numerous studies have further characteriz
Externí odkaz:
https://doaj.org/article/d543d8412ded4cb7b307a027c2b0ee85
Publikováno v:
Neurotrauma Reports, Vol 2, Iss 1, Pp 285-302 (2021)
Astrogliosis is one of the hallmarks of brain injury, and after a mild injury activated astrocytes subserve neuroprotective and pro-regenerative functions. We previously found that the astroglial response to closed head injury (CHI) was blunted in mi
Externí odkaz:
https://doaj.org/article/712219a801de4b408d4250b115a66846
Autor:
Fernando Janczur Velloso, Ekta Kumari, Krista D. Buono, Michelle J. Frondelli, Steven W. Levison
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101065- (2022)
Summary: This protocol describes an ex vivo approach to identify and quantify the proportions of proliferating neural stem cells and progenitors of the mouse subventricular zone. It uses ethynyl deoxyuridine (EdU) incorporation to identify dividing c
Externí odkaz:
https://doaj.org/article/b8d8e0fb0b2949358b85742aa609b073
Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine
Autor:
Amber N. Ziegler, Qiang Feng, Shravanthi Chidambaram, Jaimie M. Testai, Ekta Kumari, Deborah E. Rothbard, Miguel Constancia, Ionel Sandovici, Tara Cominski, Kevin Pang, Nan Gao, Teresa L. Wood, Steven W. Levison
Publikováno v:
Stem Cell Reports, Vol 12, Iss 4, Pp 816-830 (2019)
Summary: Tissue-specific stem cells have unique properties and growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches. Whereas insulin-like growth factor II (IGF-II) is n
Externí odkaz:
https://doaj.org/article/37b18af9b7bb486e8adcbcdaf7f3aeae
Autor:
Stephanie Veerasammy, Juliette Van Steenwinckel, Tifenn Le Charpentier, Joon Ho Seo, Bobbi Fleiss, Pierre Gressens, Steven W. Levison
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 7, Iss , Pp 100106- (2020)
Meta-analyses have revealed associations between the incidence of maternal infections during pregnancy, premature birth, smaller brain volumes, and subsequent cognitive, motor and behavioral deficits as these children mature. Inflammation during preg
Externí odkaz:
https://doaj.org/article/ecb2d187576e4862821de54b9aebe4b0
Autor:
Laura E. Montroull, Deborah E. Rothbard, Hur D. Kanal, Veera D’Mello, Vincent Dodson, Carol M. Troy, Juan P. Zanin, Steven W. Levison, Wilma J. Friedman
Publikováno v:
ASN Neuro, Vol 12 (2020)
The p75 neurotrophin receptor (p75NTR) can regulate multiple cellular functions including proliferation, survival, and apoptotic cell death. The p75NTR is widely expressed in the developing brain and is downregulated as the nervous system matures, wi
Externí odkaz:
https://doaj.org/article/92e8ef812bea452d99d548462c7f6eb8
Autor:
Shravanthi Chidambaram, Fernando J. Velloso, Deborah E. Rothbard, Kaivalya Deshpande, Yvelande Cajuste, Kristin M. Snyder, Eduardo Fajardo, Andras Fiser, Nikos Tapinos, Steven W. Levison, Teresa L. Wood
Publikováno v:
Stem Cell Reports. 17:1411-1427
The insulin receptor (INSR) is an evolutionarily conserved signaling protein that regulates development and cellular metabolism. INSR signaling promotes neurogenesis in Drosophila; however, a specific role for the INSR in maintaining adult neural ste
Autor:
Nolan B. Skop, Sweta Singh, Henri Antikainen, Chaitali Saqcena, Frances Calderon, Deborah E. Rothbard, Cheul H. Cho, Chirag D. Gandhi, Steven W. Levison, Radek Dobrowolski
Publikováno v:
ASN Neuro, Vol 11 (2019)
There is intense interest and effort toward regenerating the brain after severe injury. Stem cell transplantation after insult to the central nervous system has been regarded as the most promising approach for repair; however, engrafting cells alone
Externí odkaz:
https://doaj.org/article/3fd65c188d424756b45e1f8065792266
Autor:
Brian H. Kim, Maciej Jeziorek, Hur Dolunay Kanal, Viorica Raluca Contu, Radek Dobrowolski, Steven W. Levison
Publikováno v:
Cells, Vol 10, Iss 4, p 898 (2021)
Recent studies of cerebral hypoxia-ischemia (HI) have highlighted slowly progressive neurodegeneration whose mechanisms remain elusive, but if blocked, could considerably improve long-term neurological function. We previously established that the cyt
Externí odkaz:
https://doaj.org/article/55031b4d1b0947bdbb4f7b65457f6290