Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Steven W, L'Hernault"'
Autor:
Jan Schreier, Sabrina Dietz, Mandy Boermel, Viola Oorschot, Ann-Sophie Seistrup, Antonio M. de Jesus Domingues, Alfred W. Bronkhorst, Dieu An H. Nguyen, Stephanie Phillis, Elizabeth J. Gleason, Steven W. L’Hernault, Carolyn M. Phillips, Falk Butter, René F. Ketting
Publikováno v:
Nature Cell Biology. 24:217-229
Autor:
Tim L. Kroft, Elizabeth J. Gleason, Steven W. L'Hernault, Katherine L. Hill-Harfe, Huiping Ling, Miriam Ratliff
Publikováno v:
Genetics. 209:173-193
Covalent attachment of ubiquitin to substrate proteins changes their function or marks them for proteolysis, and the specificity of ubiquitin attachment is mediated by the numerous E3 ligases encoded by animals. Mind Bomb is an essential E3 ligase du
Publikováno v:
Current Biology. 27:R988-R994
Most organisms consist of two cell lineages - somatic cells and germ cells. The former are required for the current generation, and the latter create offspring. Male and female germ cells are usually produced during spermatogenesis and oogenesis, whi
Autor:
Tatsuya Tajima, Steven W. L'Hernault, Heather Skye Comstra, Elizabeth J. Gleason, Hitoshi Nishimura
Publikováno v:
Current Biology. 25:3225-3231
The Caenorhabditis elegans spe-9 class genes, which show specific or predominant expression in the male germline, are indispensable for fertilization [1, 2]. However, due to the rapid evolution of genes involved in reproduction, we do not currently k
Autor:
Miriam, Ratliff, Katherine L, Hill-Harfe, Elizabeth J, Gleason, Huiping, Ling, Tim L, Kroft, Steven W, L'Hernault
Publikováno v:
Genetics. 209(1)
Covalent attachment of ubiquitin to substrate proteins changes their function or marks them for proteolysis, and the specificity of ubiquitin attachment is mediated by the numerous E3 ligases encoded by animals. Mind Bomb is an essential E3 ligase du
Autor:
Elizabeth J. Gleason, Paul D. Hartley, Robby M. Weimer, Tim L. Kroft, Steven W. L'Hernault, Suzanne Cordovado, Guang-dan Zhu, Melissa Henderson, Paul W. Price, Katherine L. Hill-Harfe
Publikováno v:
Genetics. 191:477-491
Secretory vesicles are used during spermatogenesis to deliver proteins to the cell surface. In Caenorhabditis elegans, secretory membranous organelles (MO) fuse with the plasma membrane to transform spermatids into fertilization-competent spermatozoa
Publikováno v:
Molecular Biology of the Cell
We describe a new modality of interaction between coats and membrane tethers that provides insight into the question of what mechanisms define specific subcellular location of tethers. We propose that clathrin-dependent mechanisms segregate class C v
Publikováno v:
Cellular Logistics. 1:111-117
Membrane fusion with vacuoles, the lysosome equivalent of the yeast Saccharomyces cerevisiae, is among the best understood membrane fusion events. Our precise understanding of this fusion machinery stems from powerful genetics and elegant in vitro re
Autor:
Gloria Salazar, Steven W. L'Hernault, Michele M. Doucette, Craig J. Heilman, Allan I. Levey, Stephanie A. Zlatic, Victor Faundez, Babar Fiza, Guang-dan Zhu
Publikováno v:
Molecular Biology of the Cell. 20:1223-1240
Yeast and animal homotypic fusion and vacuole protein sorting (HOPS) complexes contain conserved subunits, but HOPS-mediated traffic in animals might require additional proteins. Here, we demonstrate that SPE-39 homologues, which are found only in an
Publikováno v:
Developmental Biology. 286(1):169-181
Fertilization, the union of sperm and egg to form a new organism, is a critical process that bridges generations. Although the cytological and physiological aspects of fertilization are relatively well understood, little is known about the molecular