Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Steven Victor O'neil"'
Autor:
Michael Paul Burns, Rajesh Kumar, Loren M. Price, Dorff Peter H, Robert John Maguire, Jeffrey T. Kohrt, Melissa Wagenaar, Manjinder S. Lall, Chewah Lee, Steven Victor O'neil
Publikováno v:
Organic Process Research & Development. 26:616-623
Spirocyclic ring systems are useful intermediates in the design and synthesis of medicinally active agents and commonly found as cores in natural products. Recently, syntheses of a key intermediate...
Autor:
Daniel P. Walker, Antonia F. Stepan, Mark A. Moen, Gregg D. Cappon, Christopher Houle, Annie C Won, Joshua R. Dunetz, Michael John Bohanon, Lei Zhang, Marc B. Skaddan, Patrick Robert Verhoest, Susan E. Drozda, Xinjun Hou, Kenneth R. Zasadny, Julie Cianfrogna, Deborah L. Smith, Ann S. Wright, John T. Lazzaro, Steven Victor O'neil, Patrick Trapa, Emily Miller, Somraj Ghosh, Gabriela Barreiro, John M. Marcek, Margaret M. Zaleska, Jason Barricklow, Michelle Marie Claffey, Lois K. Chenard, Jessica Mancuso, Christopher L. Shaffer, Jessica Whritenour, Gayatri Balan, Brian P. Boscoe, Vinod D. Parikh, Karen J. Coffman, Laigao Chen, Isao Sakurada, Jamison B. Tuttle, Matthew R. Reese, Karki Kapil Kumar
Publikováno v:
Journal of Medicinal Chemistry. 60:7764-7780
We previously observed a cutaneous type IV immune response in nonhuman primates (NHP) with the mGlu5 negative allosteric modulator (NAM) 7. To determine if this adverse event was chemotype- or mechanism-based, we evaluated a distinct series of mGlu5
Autor:
Anthony R. Harris, Susan M. Lotarski, Michael Aaron Brodney, Michael Popiolek, Catherine A. Thorn, Stephen Jenkinson, Che Wah Lee, Jennifer E. Davoren, Stefanus J. Steyn, Lei Zhang, Terrence Peter Kenakin, Betty Pettersen, Sarah Grimwood, Damien Webb, Michelle R. Garnsey, Simeon Ramsey, John T. Lazzaro, Steven Victor O'neil, Lisa Nottebaum, Jean-Philippe Fortin, Jeremy R. Edgerton
Publikováno v:
Journal of Medicinal Chemistry. 60:6649-6663
Recent data demonstrated that activation of the muscarinic M1 receptor by a subtype-selective positive allosteric modulator (PAM) contributes to the gastrointestinal (GI) and cardiovascular (CV) cholinergic adverse events (AEs) previously attributed
Autor:
Christopher Ryan Butler, Timothy J. McCarthy, Ryosuke Arakawa, Deborah L. Smith, Klaas Schildknegt, Justin R. Piro, Lei Zhang, Kevin P. Maresca, Laura A. McAllister, Deane M. Nason, Zhisheng Jia, Sangram Nag, Akihiro Takano, Tarek A. Samad, Christer Halldin, Anabella Villalobos, Steven Victor O'neil, Patrick Trapa
Publikováno v:
Journal of medicinal chemistry. 62(18)
Monoacylglycerol lipase (MAGL), a serine hydrolase extensively expressed throughout the brain, serves as a key gatekeeper regulating the tone of endocannabinoid signaling. Preclinically, inhibition of MAGL is known to provide therapeutic benefits for
Autor:
Timothy L. Foley, Justin I. Montgomery, Daniel P. Uccello, Anthony R. Harris, Steven Victor O'neil, Bruce N. Rogers, Douglas S. Johnson, Justin R. Piro, Tarek A. Samad, Christopher Ryan Butler, Stephen Noell, Rafael G. Silva, Deane M. Nason, Christopher John Helal, Adam M. Gilbert, Julie Cianfrogna, Laura A. McAllister, Scot Richard Mente, Christopher L. Shaffer, Kari R. Fonseca, Damien Webb, Jayvardhan Pandit, Michael Aaron Brodney
Publikováno v:
Journal of medicinal chemistry. 61(7)
Monoacylglycerol lipase (MAGL) inhibition provides a potential treatment approach to neuroinflammation through modulation of both the endocannabinoid pathway and arachidonoyl signaling in the central nervous system (CNS). Herein we report the discove
Autor:
Sarah J. Neal, M. Olsen, Sharon Rosenzweig-Lipson, S.K. Leonard, Zoë A. Hughes, Deborah L. Smith, Robert H. Ring, Stacey J. Sukoff Rizzo, T.H. Andree, John Dunlop, Susan M. Lotarski, C.M. Pulicicchio, Lee E. Schechter, Dane Springer, Shendi Lu, Jason M. Dwyer, Garth T. Whiteside, E. Kouranova, J.E. Harrison, Julie A. Brennan, Steven Victor O'neil, C.N. Bender
Publikováno v:
Neuropharmacology. 66:202-214
Evidence suggests that 30–50% of patients suffering from major depressive disorder (MDD) are classified as suffering from treatment resistant depression (TRD) as they have an inadequate response to standard antidepressants. A key feature of this pa
Autor:
Deane M. Nason, Keith Dlugolenski, Chewah Lee, Betty Pettersen, Gregory W. Kauffman, Lei Zhang, Carrie Northcott, Stephen Jenkinson, Yuxia Mao, Jennifer E. Davoren, Susan M. Lotarski, Veronica Reinhart, Damien Webb, Michelle R. Garnsey, Sarah Grimwood, John T. Lazzaro, Michael Aaron Brodney, Jeremy R. Edgerton, Jason Cordes, Stefanus J. Steyn, Romelia Salomon-Ferrer, Steven Victor O'neil, Terrence Peter Kenakin, Lisa Nottebaum, Michael Popiolek, Christopher John Helal, Anthony R. Harris
Publikováno v:
Journal of medicinal chemistry. 59(13)
It is hypothesized that selective muscarinic M1 subtype activation could be a strategy to provide cognitive benefits to schizophrenia and Alzheimer's disease patients while minimizing the cholinergic side effects observed with nonselective muscarinic
Publikováno v:
Expert Opinion on Therapeutic Patents. 21:1-12
Aggrecanases are members of a disintegrin and metalloprotease with thrombospondin motif family of zinc metalloproteases involved in the cleavage of aggrecan fragments in cartilage. Inhibition of aggrecanase activity in osteoarthritis (OA) patients sh
Autor:
Veronica Reinhart, Susan M. Lotarski, Stefanus J. Steyn, Jennifer E. Davoren, Lei Zhang, Erik Alphie Lachapelle, Deane M. Nason, Michael Eric Green, Keith Dlugolenski, Anthony R. Harris, Jiangli Yan, Sarah Grimwood, Michelle R. Garnsey, Chewah Lee, Dennis P. Anderson, John T. Lazzaro, R. Scott Obach, Damien Webb, Lois K. Chenard, Jeremy R. Edgerton, Michael Aaron Brodney, Romelia Salomon-Ferrer, Gregory W. Kauffman, Steven Victor O'neil
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(2)
Selective activation of the M1 receptor via a positive allosteric modulator (PAM) is a new approach for the treatment of the cognitive impairments associated with schizophrenia and Alzheimer's disease. A novel series of azaindole amides and their key