Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping

Autor: Nelda Antonovaite, Steven V. Beekmans, Elly M. Hol, Wytse J. Wadman, Davide Iannuzzi

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)

Abstract The mechanical properties of brain tissue play a pivotal role in neurodevelopment and neurological disorders. Yet, at present, there is no consensus on how the different structural parts of the tissue contribute to its stiffness variations.

Externí odkaz: https://doaj.org/article/5b22ffeb4a2d4bfb8160c64fa840b73a

Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping

Autor: Davide Iannuzzi, Nelda Antonovaite, Elly M. Hol, Steven V. Beekmans, Wytse J. Wadman

Publikováno v: Scientific Reports, 8:12517. Nature Publishing Group
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, 8(1). Nature Publishing Group
Antonovaite, N, Beekmans, S V, Hol, E M, Wadman, W J & Iannuzzi, D 2018, ' Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping ', Scientific Reports, vol. 8, 12517, pp. 1-11 . https://doi.org/10.1038/s41598-018-31035-y
Scientific Reports
Scientific Reports, 8:12517, 1-11. Nature Publishing Group

The mechanical properties of brain tissue play a pivotal role in neurodevelopment and neurological disorders. Yet, at present, there is no consensus on how the different structural parts of the tissue contribute to its stiffness variations. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab7eeaf74497b2e2cd2330ed470f86f
https://hdl.handle.net/11245.1/fcb941e2-1a93-44a1-a816-341ab2281511

Batch production of silicon fiber-top cantilever devices

Autor: Davide Iannuzzi, R. Verdoold, Steven V. Beekmans, J.H. Rector, Martin Slaman

Publikováno v: Rector, J H, Beekmans, S V, Slaman, M, Verdoold, R & Iannuzzi, D 2017, Batch production of silicon fiber-top cantilever devices . in 2017 International Conference on Optical MEMS and Nanophotonics, OMN 2017-Proceedings ., 8051500, ACM, IEEE Computer Society, 22nd International Conference on Optical MEMS and Nanophotonics, OMN 2017, Santa Fe, United States, 13/08/17 . https://doi.org/10.1109/OMN.2017.8051500
2017 International Conference on Optical MEMS and Nanophotonics, OMN 2017-Proceedings

We present a fabrication procedure for batch production of MEMS devices directly on top of an optical fiber. Here, the stepwise fabrication procedure is described and the performance of the final device is demonstrated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810b3d7e6a15685622f49b9e1c425924
https://research.vu.nl/en/publications/e64356a9-5492-4a5a-a08c-cedb96b32329

Minimally Invasive Micro-Indentation: mapping tissue mechanics at the tip of an 18G needle

Autor: Steven V. Beekmans, Theo H. Smit, Davide Iannuzzi, Kaj S. Emanuel

Publikováno v: Scientific Reports, 7(1):11364. Nature Publishing Group
Scientific Reports
Beekmans, S V, Emanuel, K S, Smit, T H & Iannuzzi, D 2017, ' Minimally Invasive Micro-Indentation : Mapping tissue mechanics at the tip of an 18G needle ', Scientific Reports, vol. 7, no. 1, 11364 . https://doi.org/10.1038/s41598-017-10526-4
Scientific reports, 7(1). Nature Publishing Group
Beekmans, S V, Emanuel, K S, Smit, T H & Iannuzzi, D 2017, ' Minimally Invasive Micro-Indentation: mapping tissue mechanics at the tip of an 18G needle ', Scientific Reports, vol. 7, no. 1, 11364 . https://doi.org/10.1038/s41598-017-10526-4
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)

Experiments regarding the mechanical properties of soft tissues mostly rely on data collected on specimens that are extracted from their native environment. During the extraction and in the time period between the extraction and the completion of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0c5a86aba6391c61dd42615ffc152f
https://doi.org/10.1038/s41598-017-10526-4

Characterizing tissue stiffness at the tip of a rigid needle using an opto-mechanical force sensor (Conference Presentation)

Autor: Steven V. Beekmans, John J. van den Dobbelsteen, Davide Iannuzzi

Publikováno v: Optical Elastography and Tissue Biomechanics III.

Each year, in the Netherlands alone, more than 50.000 percutaneous procedures are performed for treatment or for removal of tissue from possibly diseased organs, of which 30% return non-diagnostic due to erroneous needle targeting, often as a result

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbd059dce8120790cfbee008f6ffcf7d
https://doi.org/10.1117/12.2212385