Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Steven Tymonko"'
Autor:
Daniel S. Treitler, Maxime C. Soumeillant, Eric M. Simmons, Dong Lin, Bahar Inankur, Amanda J. Rogers, Michael Dummeldinger, Sergei Kolotuchin, Collin Chan, Jun Li, Adam Freitag, Federico Lora Gonzalez, Michael J. Smith, Chris Sfouggatakis, Jianji Wang, Tamas Benkovics, Joerg Deerberg, James H. Simpson, Ke Chen, Steven Tymonko
Publikováno v:
Organic Process Research & Development. 26:1202-1222
Autor:
Phil J. Borman, John Lepore, Sushil K. Srivastava, Nathan D. Ide, John Donaubauer, Steven Tymonko, Matt E. Popkin, Lindsay A. Hobson, Kevin D. Seibert, Timothy Curran, Batool Ahmed Omer, Jeffrey M. Kallemeyn, Looker Adam
Publikováno v:
Journal of Pharmaceutical Innovation. 13:367-372
This paper by IQ consortium member companies will describe how the application of the ICH Q11 vision for enhanced QbD development can lead to flexibility through differentiated outcomes for elements of API manufacture, such as the control strategy an
Autor:
Hua Gong, Thomas M. Razler, Zhongmin Xu, Victor W. Rosso, Cuniere Nicolas, Steven Tymonko, Nuria de Mas, Kenneth J. Natalie, Eric W. Sortore, Monica L. Adams, David A. Conlon, David S. Weinstein, Fernando Quiroz, Kenneth J. Fraunhoffer, Jason Zhu, Anisha Patel, Jun Huang, Doris C. Chen
Publikováno v:
Organic Process Research & Development. 20:921-933
An efficient route to two functionalized 2-aryl-5H-chromeno[2,3-b]pyridines (azaxanthenes) is reported. The addition of lithiated 2,6-dichloropyridine to salicylaldehyde followed by cyclization was a key process improvement identified for the formati
Autor:
Steven Tymonko, Tamas Benkovics, Grace M. McKenna, Francisco González-Bobes, Sha Lou, Antonio Ramirez, David A. Conlon
Publikováno v:
Organic Letters. 17:5000-5003
A syn-selective synthesis of β-branched α-amino acids has been developed based on the alkylation of glycine imine esters with secondary sulfonates. The potassium counterion for the enolate, the solvent, and the leaving group on the electrophile wer
Autor:
Steven Tymonko, Ronald L. Hanson, Matthew W. Haley, Annie Tam, Animesh Goswami, Zhongmin Xu, Ian S. Young
Publikováno v:
Organic Process Research & Development. 19:1360-1368
A scalable synthesis of (R,R)-2,6-dimethyldihydro-2H-pyran-4(3H)-one is reported. Key to this strategy is the Ti(OiPr)4-catalyzed Kulinkovich cyclopropanation of silyl protected (R)-ethyl 3-hydroxybutanoate, and subsequent oxidative fragmentation of
Autor:
Francisco González-Bobes, Grace M. McKenna, Antonio Ramirez, David A. Conlon, Tamas Benkovics, Steven Tymonko, Sha Lou
Publikováno v:
ChemInform. 47
The utility of the method is demonstrated by the synthesis of the pharmaceutically relevant glutamic acid derivative (VII) as well as the kilogram-scale preparation of (VIII).
Autor:
Ronald L. Hanson, Animesh Goswami, Zhongmin Xu, Matthew W. Haley, Annie Tam, Ian S. Young, Steven Tymonko
Publikováno v:
ChemInform. 47
Key step of the improved synthesis of title compound (VIII) is the Kulinkovich cyclopropanation, and subsequent oxidative fragmentation of the cyclopropanol (IV).