Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Steven Tuske"'
Autor:
Barry J. Byrne, Giancarlo Parenti, Benedikt Schoser, Ans T. van der Ploeg, Hung Do, Brian Fox, Mitchell Goldman, Franklin K. Johnson, Jia Kang, Nickita Mehta, John Mondick, M. Osman Sheikh, Sheela Sitaraman Das, Steven Tuske, Jon Brudvig, Jill M. Weimer, Tahseen Mozaffar
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Enzyme replacement therapy (ERT) is the only approved disease-modifying treatment modality for Pompe disease, a rare, inherited metabolic disorder caused by a deficiency in the acid α-glucosidase (GAA) enzyme that catabolizes lysosomal glycogen. Fir
Externí odkaz:
https://doaj.org/article/80f9631db5ec471a9488eaff38c0f152
Autor:
Rajiv P. Bandwar, Paul L. Boyer, Kirsten L. White, Joy Y. Feng, Eddy Arnold, Arthur D. Clark, Xiongying Tu, Kalyan Das, Xiaorong Hou, Michael D. Miller, Stefan G. Sarafianos, Roger A. Jones, Steven Tuske, Stephen H. Hughes, Barbara L. Gaffney
Publikováno v:
The Journal of Biological Chemistry
K65R is a primary reverse transcriptase (RT) mutation selected in human immunodeficiency virus type 1-infected patients taking antiretroviral regimens containing tenofovir disoproxil fumarate or other nucleoside analog RT drugs. We determined the cry
Autor:
Eddy Arnold, Stefan G. Sarafianos, Brian P. Hudson, Jayanta Mukhopadhyay, Rolf Jansen, Steven Tuske, David Koppstein, Sajida Ismail, Herbert Irschik, Minyoung Jang, Kalyan Das, Jay M. Patel, Richard H. Ebright
Publikováno v:
Cell. 135(2):295-307
Summary The α-pyrone antibiotic myxopyronin (Myx) inhibits bacterial RNA polymerase (RNAP). Here, through a combination of genetic, biochemical, and structural approaches, we show that Myx interacts with the RNAP "switch region"—the hinge that med
Publikováno v:
Journal of Virology. 78:3387-3397
Site-directed photoaffinity cross-linking experiments were performed by using human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) mutants with unique cysteine residues at several positions (i.e., positions 65, 67, 70, and 74) in th
Autor:
Youngmin Jeon, Patrick R. Griffin, Cheng Zhang, Steven Tuske, Chelsy Chesterman, William A. Cantara, Jie Zheng, Dmitry Lyumkis, Eddy Arnold, Karin Musier-Forsyth
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 73:a286-a286
Autor:
W. Gregory Alvord, Octavio A. Quiñones, Stephen H. Hughes, Andrea L. Ferris, Michael E. Abram, Eddy Arnold, Kalyan Das, Wei Shao, Steven Tuske
The genetic variation in HIV-1 in patients is due to the high rate of viral replication, the high viral load, and the errors made during viral replication. Some of the mutations in reverse transcriptase (RT) that alter the deoxynucleoside triphosphat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b548613c1ec807c4fa87b1bca320d28c
https://europepmc.org/articles/PMC4054409/
https://europepmc.org/articles/PMC4054409/
Autor:
Olivier Leroy, Richard H. Ebright, Jookyung Lee, Eddy Arnold, Sajida Ismail, Arthur D. Clark, Stefan G. Sarafianos, Chhaya Dharia, Jayanta Mukhopadhyay, Brian P. Hudson, Elena V. Sineva, Andrew A. Napoli, Sergei Borukhov, Jens J. Birktoft, Steven Tuske, Xinyue Wang, Oleg Laptenko
Publikováno v:
Cell. (4):541-552
SummaryWe define the target, mechanism, and structural basis of inhibition of bacterial RNA polymerase (RNAP) by the tetramic acid antibiotic streptolydigin (Stl). Stl binds to a site adjacent to but not overlapping the RNAP active center and stabili