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Autor:
Daun Chung, Francis Burrows, Karen Lundgren, Lin Zhang, Marco A. Biamonte, Steven Tsurumoto, Laura Neely, Yong-Ching Yang, Hong Zhang, John Brekken, Junhua Fan
Publikováno v:
Molecular Cancer Therapeutics. 5:1256-1264
The selective heat shock protein 90 (HSP90) inhibitor 17-allyamino-17-demethoxygeldanamycin (17-AAG) is currently in phase I/II clinical studies at numerous institutions. Heretofore, the biomarkers to detect 17-AAG bioactivity (Hsp70, Raf-1, and cycl