Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Steven Timmermans"'
Autor:
Céline Van Dender, Steven Timmermans, Ville Paakinaho, Tineke Vanderhaeghen, Jolien Vandewalle, Maarten Claes, Bruno Garcia, Bart Roman, Jan De Waele, Siska Croubels, Karolien De Bosscher, Philip Meuleman, Antoine Herpain, Jorma J Palvimo, Claude Libert
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2485-2515 (2024)
Abstract In sepsis, limited food intake and increased energy expenditure induce a starvation response, which is compromised by a quick decline in the expression of hepatic PPARα, a transcription factor essential in intracellular catabolism of free f
Externí odkaz:
https://doaj.org/article/a06f4ebf50eb4404b264053ba4838ecb
Autor:
Sofie J. Desmet, Jonathan Thommis, Tineke Vanderhaeghen, Edmee M.F. Vandenboorn, Dorien Clarisse, Yunkun Li, Steven Timmermans, Daria Fijalkowska, Dariusz Ratman, Evelien Van Hamme, Lode De Cauwer, Bart Staels, Luc Brunsveld, Frank Peelman, Claude Libert, Jan Tavernier, Karolien De Bosscher
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101938- (2024)
Objective: The peroxisome proliferator-activated receptor α (PPARα) is a transcription factor driving target genes involved in fatty acid β-oxidation. To what extent various PPARα interacting proteins may assist its function as a transcription fa
Externí odkaz:
https://doaj.org/article/1e23832839bc4f67a6376a644117993b
Autor:
Steven Timmermans, Charlotte Wallaeys, Natalia Garcia-Gonzalez, Lotte Pollaris, Yvan Saeys, Claude Libert
Publikováno v:
Cells, Vol 13, Iss 17, p 1435 (2024)
The small intestinal crypts harbor secretory Paneth cells (PCs) which express bactericidal peptides that are crucial for maintaining intestinal homeostasis. Considering the diverse environmental conditions throughout the course of the small intestine
Externí odkaz:
https://doaj.org/article/5c669b8bb3464122a428313edbc52580
Autor:
Claudia Theys, Tineke Vanderhaeghen, Evelien Van Dijck, Cedric Peleman, Anne Scheepers, Joe Ibrahim, Ligia Mateiu, Steven Timmermans, Tom Vanden Berghe, Sven M. Francque, Wim Van Hul, Claude Libert, Wim Vanden Berghe
Publikováno v:
Frontiers in Molecular Medicine, Vol 3 (2024)
Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) is a growing epidemic with an estimated prevalence of 20%–30% in Europe and the most common cause of chronic liver disease worldwide. The onset and progression of MASLD are orchestrat
Externí odkaz:
https://doaj.org/article/949581703c6a48e18ffca39d01ec79c1
Autor:
Tineke Vanderhaeghen, Steven Timmermans, Melanie Eggermont, Deepika Watts, Jolien Vandewalle, Charlotte Wallaeys, Louise Nuyttens, Joyca De Temmerman, Tino Hochepied, Sylviane Dewaele, Joke Vanden Berghe, Niek Sanders, Ben Wielockx, Rudi Beyaert, Claude Libert
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPolymicrobial sepsis causes acute anorexia (loss of appetite), leading to lipolysis in white adipose tissue and proteolysis in muscle, and thus release of free fatty acids (FFAs), glycerol and gluconeogenic amino acids. Since hepatic pero
Externí odkaz:
https://doaj.org/article/d4cf3b606e8c4e34ae118f7e43e47016
Autor:
Jolien Souffriau, Steven Timmermans, Tineke Vanderhaeghen, Charlotte Wallaeys, Kelly Van Looveren, Lindsy Aelbrecht, Sylviane Dewaele, Jolien Vandewalle, Evy Goossens, Serge Verbanck, Filip Boyen, Melanie Eggermont, Lindsey De Commer, Riet De Rycke, Michiel De Bruyne, Raul Tito, Marlies Ballegeer, Sofie Vandevyver, Tiago Velho, Luis Ferreira Moita, Tino Hochepied, Karolien De Bosscher, Jeroen Raes, Filip Van Immerseel, Rudi Beyaert, Claude Libert
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 10, Pp 1-21 (2020)
Abstract The cytokine TNF drives inflammatory diseases, e.g., Crohn's disease. In a mouse model of TNF‐induced systemic inflammatory response syndrome (SIRS), severe impact on intestinal epithelial cells (IECs) is observed. Zinc confers complete pr
Externí odkaz:
https://doaj.org/article/3e993b5bbeaf4e78b2bc46c529806814
Autor:
Lise Van Wyngene, Tineke Vanderhaeghen, Steven Timmermans, Jolien Vandewalle, Kelly Van Looveren, Jolien Souffriau, Charlotte Wallaeys, Melanie Eggermont, Sam Ernst, Evelien Van Hamme, Amanda Gonçalves, Guy Eelen, Anneleen Remmerie, Charlotte L Scott, Caroline Rombouts, Lynn Vanhaecke, Liesbet De Bus, Johan Decruyenaere, Peter Carmeliet, Claude Libert
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 2, Pp 1-20 (2020)
Abstract Despite intensive research and constant medical progress, sepsis remains one of the most urgent unmet medical needs of today. Most studies have been focused on the inflammatory component of the disease; however, recent advances support the n
Externí odkaz:
https://doaj.org/article/7138be713e384661805942f933a9d08d
Autor:
Jolien Vandewalle, Bruno Garcia, Steven Timmermans, Tineke Vanderhaeghen, Lise Van Wyngene, Melanie Eggermont, Hester Dufoor, Céline Van Dender, Fëllanza Halimi, Siska Croubels, Antoine Herpain, Claude Libert
Publikováno v:
Cells, Vol 11, Iss 24, p 4080 (2022)
Despite decades of research, sepsis remains one of the most urgent unmet medical needs. Mechanistic investigations into sepsis have mainly focused on targeting inflammatory pathways; however, recent data indicate that sepsis should also be seen as a
Externí odkaz:
https://doaj.org/article/f6cf66ff733845afa1be4ac620887e15
Autor:
Lise Van Wyngene, Tineke Vanderhaeghen, Ioanna Petta, Steven Timmermans, Katrien Corbeels, Bart Van der Schueren, Jolien Vandewalle, Kelly Van Looveren, Charlotte Wallaeys, Melanie Eggermont, Sylviane Dewaele, Leen Catrysse, Geert van Loo, Rudi Beyaert, Roman Vangoitsenhoven, Toshinori Nakayama, Jan Tavernier, Karolien De Bosscher, Claude Libert
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102790- (2021)
Summary: The hypothalamic-pituitary-adrenal (HPA) axis forms a complex neuroendocrine system that regulates the body’s response to stress such as starvation. In contrast with the glucocorticoid receptor (GR), Zinc finger and BTB domain containing 3
Externí odkaz:
https://doaj.org/article/3a3b104cdfd748ce878d5705d4550412
Publikováno v:
Cells, Vol 11, Iss 4, p 683 (2022)
The glucocorticoid receptor (GR) is a very versatile protein that comes in several forms, interacts with many proteins and has multiple functions. Numerous therapies are based on GRs’ actions but the occurrence of side effects and reduced responses
Externí odkaz:
https://doaj.org/article/56693cd74a2f477f9481ab0ca3636719