Výsledky vyhledávání - "Steven T. Singleton"

Akademický článek

Autor: MICHAEL D GARRICK, STEVEN T SINGLETON, FARIDA VARGAS, H-C KUO, LIN ZHAO, MARTIN KNÖPFEL, TODD DAVIDSON, MAX COSTA, PRASAD PARADKAR, JEROME A ROTH, LAURA M GARRICK

Publikováno v: Biological Research, Vol 39, Iss 1, Pp 79-85 (2006)

DMT1 _ Divalent Metal (Ion) Transporter 1 or SLC11A2/DCT1/Nramp2 _ transports Fe2+ into the duodenum and out of the endosome during the transferrin cycle. DMT1 also is important in non-transferrin bound iron uptake. It plays similar roles in Mn2+ tra

Externí odkaz: https://doaj.org/article/8865dbdf886c43c1a46a3407242da2ee

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Mouse divalent metal transporter 1 is a copper transporter in HEK293 cells

Autor: Michael D. Garrick, Miguel Arredondo, Sebastián Flores, Steven T. Singleton, Maria Jose Mendiburo

Publikováno v: BioMetals. 27:115-123

Divalent Metal Transporter 1 (DMT1) is an apical Fe transporter in the duodenum and is involved in endosomal Fe export. Four protein isoforms have been described for DMT1, two from mRNA with an iron responsive element (IRE) and two from mRNA without

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001e66611804c5bbfbdc769497ba45b3
https://doi.org/10.1007/s10534-013-9691-6

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Effect of glutamate and riluzole on manganese-induced apoptotic cell signaling in neuronally differentiated mouse P19 Cells

Autor: Steven T. Singleton, Jerome A. Roth, Swetha Sridhar

Publikováno v: Neurochemistry International. 61:25-33

Excess exposure to Mn causes a neurological disorder known as manganism which is similar to dystonic movements associated with Parkinson's disease. Manganism is largely restricted to occupations in which high atmospheric levels are prevalent which in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9621071d60da1c895514437f59c4e041
https://doi.org/10.1016/j.neuint.2012.04.015

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DMT1: Which metals does it transport?

Autor: Laura M. Garrick, Lin Zhao, Martin Knöpfel, Jerome A. Roth, Max Costa, Steven T. Singleton, Prasad N. Paradkar, H-C Kuo, Todd Davidson, Farida Vargas, Michael D. Garrick

Publikováno v: Biological Research, Vol 39, Iss 1, Pp 79-85 (2006)
Biological Research, Volume: 39, Issue: 1, Pages: 79-85, Published: 2006
Biological Research v.39 n.1 2006
SciELO Chile
CONICYT Chile
instacron:CONICYT
Scopus-Elsevier

DMT1-Divalent Metal (Ion) Transporter 1 or SLC11A2/DCT1/Nramp2 - transports Fe2+ into the duodenum and out of the endosome during the transferrin cycle. DMTI also is important in non-transferrin bound iron uptake. It plays similar roles in Mn2+ traff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552a907e484ffcdda6c6f75077a875d0
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100009

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Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells

Autor: Steven T. Singleton, Todd Davidson, Haobin Chen, Michael D. Garrick, Max Costa

Publikováno v: Toxicology and Applied Pharmacology. 206:275-287

Nickel (Ni) compounds are well-established carcinogens and are known to initiate a hypoxic response in cells via the stabilization and transactivation of hypoxia-inducible factor-1 alpha (HIF-1alpha). This change may be the consequence of nickel's in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576041b1a71462f5ba68c7b0ef22db0f
https://doi.org/10.1016/j.taap.2004.11.011

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Longitudinal assessment of occupational exposures to the organophosphorous insecticides chlorpyrifos and profenofos in Egyptian cotton field workers

Autor: Matthew R. Bonner, Fayssal M. Farahat, Richard A. Fenske, Steven T. Singleton, Oswald A. Dadson, Taghreed M Farahat, Diane S. Rohlman, Pamela J. Lein, Barbara P. McGarrigle, Kit Galvin, W. Kent Anger, James R. Olson, Michael R. Lasarev

Publikováno v: Singleton, Steven T; Lein, Pamela J; Dadson, Oswald A; McGarrigle, Barbara P; Farahat, Fayssal M; Farahat, Taghreed; et al.(2015). Longitudinal assessment of occupational exposures to the organophosphorous insecticides chlorpyrifos and profenofos in Egyptian cotton field workers.. International journal of hygiene and environmental health, 218(2), 203-211. doi: 10.1016/j.ijheh.2014.10.005. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/2jc9s3rt
International journal of hygiene and environmental health, vol 218, iss 2

Chlorpyrifos (CPF) and profenofos (PFF) are organophosphorus (OP) insecticides that are applied seasonally in Egypt to cotton fields. Urinary trichloro-2-pyridinol (TCPy), a specific CPF metabolite, and 4-bromo-2-chlorophenol (BCP), a specific PFF me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c610a3272dc82e01b3f6836d486f7525
https://pubmed.ncbi.nlm.nih.gov/25466362

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Characterization of α-cypermethrin exposure in Egyptian agricultural workers

Autor: Pamela J. Lein, Fayssal M. Farahat, Steven T. Singleton, James B. Knaak, Matthew R. Bonner, James R. Olson, Taghreed M Farahat

Publikováno v: Singleton, Steven T; Lein, Pamela J; Farahat, Fayssal M; Farahat, Taghreed; Bonner, Matthew R; Knaak, James B; et al.(2014). Characterization of α-cypermethrin exposure in Egyptian agricultural workers.. International journal of hygiene and environmental health, 217(4-5), 538-545. doi: 10.1016/j.ijheh.2013.10.003. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7tg5v58h
International journal of hygiene and environmental health, vol 217, iss 4-5

Pyrethroids are neurotoxic insecticides that exert their effects by prolonging the open time of sodium channels, which increases the duration of neuronal excitation. α-cypermethrin (αCM) is derived from the 8-stereoisomers that together make up the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99d002fa182e466f73d2e87233137e8
http://www.escholarship.org/uc/item/7tg5v58h

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Longitudinal Assessment of Chlorpyrifos Exposure and Effect Biomarkers in Adolescent Egyptian Agricultural Workers

Autor: Diane S. Rohlman, Gaafar Abdel Rasoul, Alice Crane, Ahmed A. Ismail, Olfat Hendy, Michael R. Lasarev, Steven T. Singleton, MA Al-Batanony, Khalid M. Khan, Matthew R. Bonner, James R. Olson

Chlorpyrifos (CPF) is applied seasonally in Egypt by adolescent agricultural workers and the extent of occupational exposure and the potential for environmental CPF exposure in this population is poorly understood. Adolescent pesticide applicators (n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ccf9d2555d783997d71879b5598157
https://europepmc.org/articles/PMC3926695/

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Metabolism of profenofos to 4-bromo-2-chlorophenol, a specific and sensitive exposure biomarker

Autor: Lai Har Chi, Barbara P. McGarrigle, Steven T. Singleton, Fayssal M. Farahat, Corie A. Ellison, Oswald A. Dadson, James R. Olson, Taghreed M Farahat, Pamela J. Lein

Publikováno v: Toxicology, vol 306

Profenofos is a direct acting phosphorothioate organophosphorus (OP) pesticide capable of inhibiting β-esterases such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. Profenofos is known to be detoxified to the biologically inac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053907186bc9c238b50e80516ea535a2
https://pubmed.ncbi.nlm.nih.gov/23415833

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Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1

Autor: Jian Feng, Steven T. Singleton, Prasad N. Paradkar, Jerome A. Roth, Michael D. Garrick

Publikováno v: Journal of neurochemistry. 113(2)

Abnormal iron accumulation is linked to a variety of neurological disorders and may contribute to the progressive damage seen in these diseases. The biochemical processes responsible for iron accumulation are not known but are likely to entail altera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7de5aed789c27eef6802d4bb56e2be
https://pubmed.ncbi.nlm.nih.gov/20089134

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