Zobrazeno 1 - 10
of 445
pro vyhledávání: '"Steven T. Rosen"'
Autor:
Meilin Xue, Lei Dong, Honghai Zhang, Yangchan Li, Kangqiang Qiu, Zhicong Zhao, Min Gao, Li Han, Anthony K. N. Chan, Wei Li, Keith Leung, Kitty Wang, Sheela Pangeni Pokharel, Ying Qing, Wei Liu, Xueer Wang, Lili Ren, Hongjie Bi, Lu Yang, Chao Shen, Zhenhua Chen, Laleh Melstrom, Hongzhi Li, Nikolai Timchenko, Xiaolan Deng, Wendong Huang, Steven T. Rosen, Jingyan Tian, Lin Xu, Jiajie Diao, Chun-Wei Chen, Jianjun Chen, Baiyong Shen, Hao Chen, Rui Su
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-24 (2024)
Abstract Background While liver cancer stem cells (CSCs) play a crucial role in hepatocellular carcinoma (HCC) initiation, progression, recurrence, and treatment resistance, the mechanism underlying liver CSC self-renewal remains elusive. We aim to c
Externí odkaz:
https://doaj.org/article/b8cac747695b48e59f1516ff7bd9a5a7
Autor:
Tamara Mirzapoiazova, Liz Tseng, Bolot Mambetsariev, Haiqing Li, Chih-Hong Lou, Alex Pozhitkov, Sravani Keerthi Ramisetty, Sangkil Nam, Isa Mambetsariev, Brian Armstrong, Jyoti Malhotra, Leonidas Arvanitis, Mohd Wasim Nasser, Surinder K. Batra, Steven T. Rosen, Deric L. Wheeler, Sharad S. Singhal, Prakash Kulkarni, Ravi Salgia
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110132- (2024)
Summary: Although up to 80% small cell lung cancer (SCLC) patients’ response is good for first-line chemotherapy regimen, most patients develop recurrence of the disease within weeks to months. Here, we report cytostatic effect of leflunomide (Lefl
Externí odkaz:
https://doaj.org/article/c1d2afcf8682490aa1a6bb5963b1e1f1
Publikováno v:
Cell Insight, Vol 3, Iss 2, Pp 100150- (2024)
As the dynamic evolution of SARS-CoV-2 led to reduced efficacy in monoclonal neutralizing antibodies and emergence of immune escape, the role of bispecific antibodies becomes crucial in bolstering antiviral activity and suppressing immune evasion. Th
Externí odkaz:
https://doaj.org/article/b5a4952f5af2440aae968b401023b566
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Recently, cancer immunotherapy has revolutionized cancer treatment. Various forms of immunotherapy have a manageable safety profile and result in prolongation of overall survival in patients with solid tumors, but only in a proportion of patients. Va
Externí odkaz:
https://doaj.org/article/18a1cfa7eccf4906a45de9636f67d9a2
Autor:
James Godfrey, Matthew Mei, Lu Chen, Joo Y. Song, Victoria Bedell, Elizabeth Budde, Saro Armenian, Sandrine Puverel, Liana Nikolaenko, Robert Chen, Shari Daniels, Neena Kennedy, Lacolle Peters, Steven T. Rosen, Stephen J. Forman, Leslie L. Popplewell, Larry W. Kwak, Alex F. Herrera
Publikováno v:
Haematologica, Vol 109, Iss 2 (2023)
Outcomes after programmed death-1 (PD-1) blockade in B-cell lymphomas are disappointing with few durable responses. Histone deacetylase inhibitors exhibit favorable immunomodulatory effects and demonstrate synergistic anti-tumor immune responses with
Externí odkaz:
https://doaj.org/article/ca13d2b46a794156a04e53d9d477b58f
Autor:
Zhen Han, Xiwei Wu, Hanjun Qin, Yate-Ching Yuan, Daniel Schmolze, Chingyu Su, Jasmine Zain, Lilach Moyal, Emmilia Hodak, James F. Sanchez, Peter P. Lee, Mingye Feng, Steven T. Rosen, Christiane Querfeld
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Cutaneous T cell lymphoma (CTCL) is a disfiguring and incurable disease characterized by skin-homing malignant T cells surrounded by immune cells that promote CTCL growth through an immunosuppressive tumor microenvironment (TME). Preliminary data fro
Externí odkaz:
https://doaj.org/article/aea90ab340bd4aec9702c4b9ba05a095
Autor:
Mingli Li, Lu Yang, Anthony K. N. Chan, Sheela Pangeni Pokharel, Qiao Liu, Nicole Mattson, Xiaobao Xu, Wen‐Han Chang, Kazuya Miyashita, Priyanka Singh, Leisi Zhang, Maggie Li, Jun Wu, Jinhui Wang, Bryan Chen, Lai N. Chan, Jaewoong Lee, Xu Hannah Zhang, Steven T. Rosen, Markus Müschen, Jun Qi, Jianjun Chen, Kevin Hiom, Alexander J. R. Bishop, Chun‐Wei Chen
Publikováno v:
Advanced Science, Vol 10, Iss 17, Pp n/a-n/a (2023)
Abstract Epigenetic dysregulation is reported in multiple cancers including Ewing sarcoma (EwS). However, the epigenetic networks underlying the maintenance of oncogenic signaling and therapeutic response remain unclear. Using a series of epigenetics
Externí odkaz:
https://doaj.org/article/d8eb48a7527744de8eb5ea7136bf0bee
Autor:
Anil Kumar, Min Huang, Norman J. Lacayo, Holden T. Maecker, Stephen J. Forman, Srividya Swaminathan, Caroline Duault, Jianhua Yu, Steven T. Rosen, Anthony Chan, Martin Carroll, Adeleh Taghi Khani, Soraya Aramburo, Ashly Sanchez Ortiz, Sung June Lee, Tinisha McDonald, Kathleen M. Sakamoto, Christian Hurtz, Sarah K. Tasian, Lucy Ghoda, Guido Marcucci, Zhaohui Gu, Saro Armenian, Shai Izraeli, Chun-Wei Chen, Michael A. Caligiuri
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Type I interferons (IFN-Is), secreted by hematopoietic cells, drive immune surveillance of solid tumors. However, the mechanisms of suppression of IFN-I-driven immune responses in hematopoietic malignancies including B-cell acute lymphobla
Externí odkaz:
https://doaj.org/article/fe41859c6f9543c091bbe4f40f81980e
Autor:
Li Du, Wei Liu, Grace Aldana-Masangkay, Alex Pozhitkov, Flavia Pichiorri, Yuan Chen, Steven T. Rosen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Abstract Background Multiple myeloma (MM) is an incurable plasma cell malignancy. Although Dexamethasone (Dex) is the most widely used therapeutic drug in MM treatment, patients develop Dex resistance leading to progressive disease, demanding an urge
Externí odkaz:
https://doaj.org/article/16139c215ba8442bbcd1c6255a6a6a29
Autor:
Nicholas A. Trum, BS, Jasmine Zain, MD, Chelsea Abad, NP, Steven T. Rosen, MD, Christiane Querfeld, MD, PhD
Publikováno v:
JAAD Case Reports, Vol 14, Iss , Pp 37-42 (2021)
Externí odkaz:
https://doaj.org/article/8c4832537b7a47c79bc5bb1dac9338eb