Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Steven T. Pals"'
Autor:
Marthe Minderman, Hildo Lantermans, Carmen van der Zwaan, Arie J. Hoogendijk, Maartje van den Biggelaar, Marie José Kersten, Marcel Spaargaren, Steven T. Pals
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract MYD88 is the key signaling adaptor-protein for Toll-like and interleukin-1 receptors. A somatic L265P mutation within the Toll/interleukin-1 receptor (TIR) domain of MYD88 is found in 90% of Waldenström macroglobulinemia cases and in a sign
Externí odkaz:
https://doaj.org/article/6567367aa7a8454c9dcdd166992c7d1a
Autor:
Marthe Minderman, Hildo C. Lantermans, Leonie J. Grüneberg, Saskia A. G. M. Cillessen, Richard J. Bende, Carel J. M. van Noesel, Marie José Kersten, Steven T. Pals, Marcel Spaargaren
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The paracaspase mucosa-associated lymphoid tissue 1 (MALT1) is a protease and scaffold protein essential in propagating B-cell receptor (BCR) signaling to NF-κB. The deubiquitinating enzyme cylindromatosis (CYLD) is a recently discovered MA
Externí odkaz:
https://doaj.org/article/fa21a09a30c54eef9cb4825a4c293ec2
Autor:
Martin F. M. de Rooij, Yvonne J. Thus, Nathalie Swier, Roderick L. Beijersbergen, Steven T. Pals, Marcel Spaargaren
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Targeting integrin-mediated retention of malignant B cells in their protective microenvironment is an efficacious treatment for lymphoma and leukemia. Here, the authors present an unbiased loss-of-adhesion CRISPR screening method, identifying therape
Externí odkaz:
https://doaj.org/article/cf11224d056d474e933c4bbc83561105
Autor:
Yvonne J. Thus, Martin F.M. de Rooij, Nathalie Swier, Roderick L. Beijersbergen, Jeroen E.J. Guikema, Marie-José Kersten, Eric Eldering, Steven T. Pals, Arnon P. Kater, Marcel Spaargaren
Publikováno v:
Haematologica, Vol 108, Iss 3 (2022)
BCL-2 family proteins are frequently aberrantly expressed in mantle cell lymphoma (MCL). Recently, the BCL-2-specific inhibitor venetoclax has been approved by the US Food and Drug Administration for chronic lymphocytic leukemia (CLL) and acute myelo
Externí odkaz:
https://doaj.org/article/44bb043e875f4dc08f5f043e88f5f9bc
Autor:
Zemin Ren, Hildo Lantermans, Annemieke Kuil, Willem Kraan, Fernando Arenzana-Seisdedos, Marie José Kersten, Marcel Spaargaren, Steven T. Pals
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Background The survival and proliferation of multiple myeloma (MM) cells in the bone marrow (BM) critically depend on interaction with stromal cells expressing the chemokine CXCL12. CXCL12 regulates the homing to the BM niche by mediating th
Externí odkaz:
https://doaj.org/article/6fe651d0fce74e0a8a070beae4ab4b46
Autor:
Marthe Minderman, Steven T. Pals
Publikováno v:
Haematologica, Vol 105, Iss 9 (2020)
Externí odkaz:
https://doaj.org/article/2286aa5af9c648d0b7097439141a1ae0
Autor:
Joost S. Vermaat, Sebastiaan F. Somers, Liesbeth C. de Wreede, Willem Kraan, Ruben A.L. de Groen, Anne M. R. Schrader, Emile D. Kerver, Cornelis G. Scheepstra, Henriëtte Berenschot, Wendy Deenik, Jurgen Wegman, Rianne Broers, Jan-Paul D. de Boer, Marcel Nijland, Tom van Wezel, Hendrik Veelken, Marcel Spaargaren, Arjen H. Cleven, Marie José Kersten, Steven T. Pals
Publikováno v:
Haematologica, Vol 105, Iss 2 (2020)
The 2016 World Health Organization classification defines diffuse large B-cell lymphoma (DLBCL) subtypes based on Epstein-Barr virus (EBV) infection and oncogenic rearrangements of MYC/BCL2/BCL6 as drivers of lymphomagenesis. A subset of DLBCL, howev
Externí odkaz:
https://doaj.org/article/93ed3bb67e6c40e09d22bd1f61cc4a61
Autor:
Ruben A.L. de Groen, Anne M.R. Schrader, Marie José Kersten, Steven T. Pals, Joost S.P. Vermaat
Publikováno v:
Haematologica, Vol 104, Iss 12 (2019)
More than 50 subtypes of B-cell non-Hodgkin lymphoma (B-NHL) are recognized in the most recent World Health Organization classification of 2016. The current treatment paradigm, however, is largely based on ‘one-size-fits-all’ immune-chemotherapy.
Externí odkaz:
https://doaj.org/article/d9b1ff714d744aa5850ef3e064116b59
Autor:
Zemin Ren, Hildo Lantermans, Annemieke Kuil, Willem Kraan, Fernando Arenzana-Seisdedos, Marie José Kersten, Marcel Spaargaren, Steven T. Pals
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/9cdb70063be24c76a30a763310fb5fd1
Autor:
Marieke L. Nijland, Lianne Koens, Steven T. Pals, Ineke J.M. ten Berge, Frederike J. Bemelman, Marie José Kersten
Publikováno v:
Haematologica, Vol 103, Iss 3 (2018)
Although it is known that B-cell lymphomas occur more frequently in immunocompromised patients, thus far such an association has not been clearly established for T-cell lymphomas. Of the 251 patients who were diagnosed with a T-cell non-Hodgkin lymph
Externí odkaz:
https://doaj.org/article/f1bf5a6444344ef29636392b1e5dc4b0