An integrated approach for characterizing immunogenic responses toward a bispecific antibody

Autor: Sivan Cohen, Shan Chung, Christoph Spiess, Victor Lundin, Eric Stefanich, Steven T. Laing, Vanessa Clark, Jochen Brumm, Ying Zhou, Catherine Huang, Joyce Guerrero, Srividya Myneni, Rajbharan Yadav, Ketevan Siradze, Kun Peng

Publikováno v: mAbs, Vol 13, Iss 1 (2021)

Bispecific antibodies (bsAbs) recognize and bind two different targets or two epitopes of the same antigen, making them an attractive diagnostic and treatment modality. Compared to the production of conventional bivalent monospecific antibodies, bsAb

Externí odkaz: https://doaj.org/article/94fdf7b855084e94b55121a2d490ecd9

Retinal and Lens Degeneration in New Zealand White Rabbits Administered Intravitreal TSG-6 Link Domain-Rabbit FAb Fusion Proteins

Autor: Susan Crowell, Nardos Tassew, Roxanne Andaya, Robert F. Kelley, Mandy Kwong, Kelly M. Loyet, Steven T Laing, Aija Kusi, Yue Wang, Julia Gray, Devin Tesar

Publikováno v: Toxicologic Pathology. 49:634-646

Fusion of biologic therapeutics to hyaluronic acid binding proteins, such as the link domain (LD) of Tumor necrosis factor (TNF)-Stimulated Gene-6 (TSG-6), is expected to increase vitreous residence time following intravitreal injection and provide f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6aba9ad9f94b54560c64be1c821c12
https://doi.org/10.1177/0192623320969124

Contributors

Autor: Rick Adler, Famke Aeffner, Laura E. Armstrong, Dmitri Artemov, Adam D. Aulbach, Bindu M. Bennet, Eric A. Blomme, Brad Bolon, Christopher J. Bowman, Molly Boyle, Alys Bradley, Dino Bradley, Danielle Brown, Pierre R. Bushel, Ellen Cannady, Mark F. Cesta, Curtis Chan, Jennifer A. Chilton, Peter J.M. Clements, Torrie A. Crabbs, Myrtle A. Davis, Sandy Eldridge, Daniela Ennulat, Jeffrey Everitt, Isabel Figueroa, James D. Fikes, Thomas Forest, Catherine A. Foss, John R. Foster, Kathleen Gabrielson, Shayne C. Gad, Kapil Gadkar, Jinping Gan, David Garcia-Tapia, Frank J. Geoly, Wendy G. Halpern, Jerry F. Hardisty, Wanda M. Haschek, Kathleen Marie Heinz-Taheny, Kristi Helke, Lauren E. Himmel, Mark J. Hoenerhoff, Jennifer L. Ingram–Ross, Armando R. Irizarry Rovira, Evan B. Janovitz, Kishore Katyayan, Charlotte M. Keenan, Angela King-Herbert, Steven T. Laing, Lois D. Lehman-McKeeman, Na Li, Calvert Louden, Claire Lyons, Kevin McDorman, Elizabeth McInnes, Lyn Miller Wancket, Sheroy Minocherhomji, Sébastien Monette, James Morrison, Vasanthi Mowat, Sydney Mukaratirwa, Keith Nelson, Arun R. Pandiri, Tracey Papenfuss, Nita Patel, Daniel J. Patrick, Shari A. Price, Deepa B. Rao, James T. Raymond, Jennifer Rojko, Colin G. Rousseaux, Sara F. Santagostino, Aaron Sargeant, Christina Satterwhite, A. Eric Schultze, Vanessa Schumacher, Cheryl Scudamore, Keith R. Shockley, Bhanu P. Singh, David M. Stresser, Polina Sysa-Shah, Debra A. Tokarz, Terry Van Vleet, Matthew A. Wallig, Jin Wang, Cynthia J. Willson, Kristin Lewis Wilson, Christopher T. Winkelmann, Jeffrey C. Wolf, Charles Wood, Daniela Bumbaca Yadav, Mark Zarella

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3831ed61c4599a4d47034bfb7e19d99
https://doi.org/10.1016/b978-0-12-821044-4.01002-5

Fab-Nanolipoprotein Conjugate Causes Vitreous Opacity and Cataracts Following a Single Intravitreal Administration in New Zealand White Rabbits

Autor: Kelly M. Loyet, Steven T Laing, Craig Blanchette, Nardos Tassew, Whitney Shatz, Chris Schuetz, Susan Crowell

Publikováno v: Toxicologic pathology. 49(3)

One strategy employed to prolong the ocular half-life of large molecule therapeutics is via covalent attachment to a carrier, resulting in an increase in size thereby slowing their clearance from the eye. Rabbit antigen-binding fragment conjugated to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fecc6eda937f3617dbc233f4fdeb41d
https://pubmed.ncbi.nlm.nih.gov/33733956

Tolerability Assessment of Formulation pH in New Zealand White Rabbits Following Intravitreal Administration

Autor: Isabella de Jong, Steven T Laing, Florence Lorget, Jeffrey Aaronson, Chris Schuetz, Nardos Tassew

Publikováno v: Toxicologic pathology. 49(3)

Development of intravitreal drugs presents several challenges due to the delicate ocular environment and volume constraints of what can be safely administered in the eye. Formulation development of intravitreally administered drugs may necessitate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d4ca1f635f0d0c0c5e59630af11b68
https://pubmed.ncbi.nlm.nih.gov/33252028