Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Steven T. Gregory"'
Publikováno v:
Antibiotics, Vol 10, Iss 11, p 1384 (2021)
Rhodothermus marinus is a halophilic extreme thermophile, with potential as a model organism for studies of the structural basis of antibiotic resistance. In order to facilitate genetic studies of this organism, we have surveyed the antibiotic sensit
Externí odkaz:
https://doaj.org/article/1a18f87c42764ee38afae6120ef9ca77
Publikováno v:
Antibiotics, Vol 9, Iss 6, p 313 (2020)
Tiamulin is a semisynthetic pleuromutilin antibiotic that binds to the 50S ribosomal subunit A site and whose (((2-diethylamino)ethyl)thio)-acetic acid tail extends into the P site to interfere with peptide bond formation. We have isolated spontaneou
Externí odkaz:
https://doaj.org/article/fab74adf45164b9fbcbbfbcda470ac9a
Autor:
Maxim S. Svetlov, Gemma C. Atkinson, Alexander S. Mankin, Elena V. Aleksandrova, Yury S. Polikanov, Egor A Syroegin, Steven T. Gregory
Publikováno v:
Nature chemical biology
Many antibiotics inhibit bacterial growth by binding to the ribosome and interfering with protein biosynthesis. Macrolides represent one of the most successful classes of ribosome-targeting antibiotics. The main clinically relevant mechanism of resis
Autor:
Reza Khayat, Bryant Avila, Barbara E. Murray, Eileen L Murphy, Gerwald Jogl, Kurt L. Krause, Steven T. Gregory, Torsten Kleffmann, Kavindra V. Singh
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Enterococcus faecalis is a gram-positive organism responsible for serious infections in humans, but as with many bacterial pathogens, resistance has rendered a number of commonly used antibiotics ineffective. Here, we report the cryo-EM structure of
Publikováno v:
Antibiotics, Vol 10, Iss 1384, p 1384 (2021)
Antibiotics
Volume 10
Issue 11
Antibiotics
Volume 10
Issue 11
Rhodothermus marinus is a halophilic extreme thermophile, with potential as a model organism for studies of the structural basis of antibiotic resistance. In order to facilitate genetic studies of this organism, we have surveyed the antibiotic sensit
Autor:
Steven T. Gregory
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50c1dbe6bd57bda20c3fb4b9fcec2a7f
https://doi.org/10.1016/b978-0-12-819460-7.00277-2
https://doi.org/10.1016/b978-0-12-819460-7.00277-2
Publikováno v:
Antibiotics
Volume 9
Issue 6
Antibiotics, Vol 9, Iss 313, p 313 (2020)
Volume 9
Issue 6
Antibiotics, Vol 9, Iss 313, p 313 (2020)
Tiamulin is a semisynthetic pleuromutilin antibiotic that binds to the 50S ribosomal subunit A site and whose (((2-diethylamino)ethyl)thio)-acetic acid tail extends into the P site to interfere with peptide bond formation. We have isolated spontaneou
Publikováno v:
Biochimie
In bacteria, ribosomal protein bL12 forms the prominent stalk structure on the ribosome and binds to multiple, distinct translational GTPase factors during the sequential steps of translation. Using a genetic selection in E. coli for altered readthro
Publikováno v:
Journal of Bacteriology. 197:1017-1025
Ribosomal proteins S4 and S5 participate in the decoding and assembly processes on the ribosome and the interaction with specific antibiotic inhibitors of translation. Many of the characterized mutations affecting these proteins decrease the accuracy
Autor:
Jennifer F. Carr, Steven T. Gregory, Gerwald Jogl, Jacqueline L. Connetti, Albert E. Dahlberg
Publikováno v:
Journal of Bacteriology. 196:3776-3783
During protein synthesis, the ribosome undergoes conformational transitions between functional states, requiring communication between distant structural elements of the ribosome. Despite advances in ribosome structural biology, identifying the prote