Zobrazeno 1 - 10
of 446
pro vyhledávání: '"Steven T Rosen"'
Publikováno v:
eJHaem, Vol 1, Iss 1, Pp 300-303 (2020)
Abstract Lymph nodes are important front‐line defense immune tissues, which also act against inflammatory diseases and cancer. Lymph nodes undergo extensive upheavals within newly formed germinal centers (GCs) when exposed to antigens, the molecula
Externí odkaz:
https://doaj.org/article/c534ea0929494478869d33333636f25c
Autor:
Samuel K McBrayer, Michael Yarrington, Jun Qian, Gang Feng, Mala Shanmugam, Varsha Gandhi, Nancy L Krett, Steven T Rosen
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41455 (2012)
The nucleoside analogues 8-amino-adenosine and 8-chloro-adenosine have been investigated in the context of B-lineage lymphoid malignancies by our laboratories due to the selective cytotoxicity they exhibit toward multiple myeloma (MM), chronic lympho
Externí odkaz:
https://doaj.org/article/ce2dd1a9fa4b4a2182000f7cef7092bb
Autor:
Ralf Buettner, Corey Morales, Xiwei Wu, James F. Sanchez, Hongzhi Li, Laleh G. Melstrom, Steven T. Rosen
Publikováno v:
Molecular Therapy: Oncolytics, Vol 14, Iss , Pp 149-158 (2019)
The immunosuppressive agent leflunomide has been used in the treatment of over 300,000 patients with rheumatoid arthritis. Its active metabolite, teriflunomide (Ter), directly inhibits dihydroorotate dehydrogenase (DHODH), an enzyme involved in nucle
Externí odkaz:
https://doaj.org/article/7c54185b871c42849daed3aecfbbae7e
Autor:
Yiming Wu, Meiling Jin, Mike Fernandez, Kevyn L. Hart, Aijun Liao, Xinzhou Ge, Stacey M. Fernandes, Tinisha McDonald, Zhenhua Chen, Daniel Röth, Lucy Y. Ghoda, Guido Marcucci, Markus Kalkum, Raju K. Pillai, Alexey V. Danilov, Jingyi Jessica Li, Jianjun Chen, Jennifer R. Brown, Steven T. Rosen, Tanya Siddiqi, Lili Wang
Publikováno v:
Blood Cancer Discovery. 4:228-245
RNA splicing dysregulation underlies the onset and progression of cancers. In chronic lymphocytic leukemia (CLL), spliceosome mutations leading to aberrant splicing occur in ∼20% of patients. However, the mechanism for splicing defects in spliceoso
Autor:
Dinh Hoa Hoang, Corey Morales, Ivan Rodriguez Rodriguez, Melissa Valerio, Jiamin Guo, Min-Hsuan Chen, Xiwei Wu, David Horne, Varsha Gandhi, Lisa S. Chen, Bin Zhang, Vinod Pullarkat, Steven T. Rosen, Guido Marcucci, Ralf Buettner, Le Xuan Truong Nguyen
Publikováno v:
Cancers, Vol 14, Iss 6, p 1446 (2022)
It is known that 8-chloro-adenosine (8-Cl-Ado) is a novel RNA-directed nucleoside analog that targets leukemic stem cells (LSCs). In a phase I clinical trial with 8-Cl-Ado in patients with refractory or relapsed (R/R) AML, we observed encouraging but
Externí odkaz:
https://doaj.org/article/5828136d7d964d3f83462b45fe69048c
Publikováno v:
Current opinion in oncology. 34(5)
In this review, we summarize the biological roles of methionine, methionine adenosyl transferase 2A (MAT2A) and S -adenosyl methionine (SAM) in methylation reactions during tumorigenesis. Newly emerged inhibitors targeting the methionine-MAT2A-SAM ax
Autor:
Alex F Herrera, Lu Chen, Yago Nieto, Leona Holmberg, Patrick Johnston, Matthew Mei, Leslie Popplewell, Saro Armenian, Thai Cao, Leonardo Farol, Firoozeh Sahebi, Ricardo Spielberger, Robert Chen, Auayporn Nademanee, Sandrine Puverel, Mary Nwangwu, Peter Lee, Joo Song, Alan Skarbnik, Neena Kennedy, Lacolle Peters, Steven T Rosen, Larry W Kwak, Stephen J Forman, Tatyana Feldman
Publikováno v:
The Lancet Haematology. 10:e14-e23
Autor:
Swetha Kambhampati, Monica Saumoy, Yecheskel Schneider, Steve Serrao, Pejman Solaimani, Lihua Elizabeth Budde, Matthew G. Mei, Leslie L. Popplewell, Tanya Siddiqi, Jasmine Zain, Stephen J. Forman, Larry W. Kwak, Steven T. Rosen, Alexey V. Danilov, Alex F. Herrera, Nikhil R. Thiruvengadam
Publikováno v:
Blood. 140:2024-2036
The ZUMA-7 (Efficacy of Axicabtagene Ciloleucel Compared to Standard of Care Therapy in Subjects With Relapsed/Refractory Diffuse Large B Cell Lymphoma) study showed that axicabtagene ciloleucel (axi-cel) improved event-free survival (EFS) compared w
Autor:
Robert W. Chen, Joycelynne M. Palmer, Sarah Tomassetti, Leslie L. Popplewell, Jessica Alluin, Pritsana Chomchan, Auayporn P. Nademanee, Tanya Siddiqi, Ni-Chun Tsai, Lu Chen, Fay Zuo, Rosemarie Abary, Ji-lian Cai, Alex F. Herrera, John J. Rossi, Steven T. Rosen, Stephen J. Forman, Larry W. Kwak, Leona A. Holmberg
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-7 (2018)
Abstract Background Mantle cell lymphoma (MCL) is an aggressive and incurable lymphoma. Standard of care for younger patients with MCL is induction chemotherapy followed by autologous stem cell transplantation (auto-HCT). Rituximab maintenance after
Externí odkaz:
https://doaj.org/article/2c3564466ed04bbbb46e3c36e69657ed
Autor:
Alex F. Herrera, Lu Chen, Jennifer L. Crombie, Jonathon B. Cohen, Ranjana H. Advani, Ann S. LaCasce, Leslie L. Popplewell, Sandrine Puverel, Lacolle Peters, Shari Daniels, James Godfrey, Geoffrey Shouse, Matthew Mei, Swetha Kambhampati, L. Elizabeth Budde, Liana Nikolaenko, Steven T. Rosen, Larry W. Kwak, Stephen J Forman, Matthew J. Matasar
Publikováno v:
Blood. 140:1065-1067