Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Steven Swallow"'
Autor:
Stacey Renee Spencer, Vincent Leveque, Fell Jay Bradford, John A. Josey, Stengel Peter J, John P. Fischer, Robert Than Hendricks, April L. Bernacki, James F. Blake, Sophie Le Pogam, Sonal Rajyaguru, Steven Swallow, Robinson John E, Isabel Najera, Harris Jason R
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3637-3641
The importance of internal hydrogen bonding in a series of benzothiadiazine and 1,4-benzothiazine NS5b inhibitors has been explored. Computational analysis has been used to compare the protonated vs. anionic forms of each series and we demonstrate th
Autor:
Xiao-Xiong Zhou, Mark D. Smith, Hans Maag, David Bernard Smith, Isabel Najera, Genadiy Kalayanov, Sophie Le Pogam, Tatiana Maltseva, Vincent Leveque, Ann C. Kaiser, Kurt Benkestock, Anna Winqvist, Nils Gunnar Johansson, Steven Swallow, Sonal Rajyaguru, Joseph A. Martin, Christian Sund, Nick Cammack, Klaus Klumpp
Publikováno v:
Journal of Medicinal Chemistry. 52:2971-2978
The discovery of 4'-azidocytidine (3) (R1479) (J. Biol. Chem. 2006, 281, 3793; Bioorg. Med. Chem. Lett. 2007, 17, 2570) as a potent inhibitor of RNA synthesis by NS5B (EC(50) = 1.28 microM), the RNA polymerase encoded by hepatitis C virus (HCV), has
Autor:
Steven, Swallow
Publikováno v:
Progress in medicinal chemistry. 54
Since its first use in the steroid field in the late 1950s, the use of fluorine in medicinal chemistry has become commonplace, with the small electronegative fluorine atom being a key part of the medicinal chemist's repertoire of substitutions used t
Publikováno v:
Tetrahedron: Asymmetry. 12:535-538
A new chiral 3-aryl- N -alkoxycarbonyloxaziridine, derived from menthol, has been prepared and tested as a reagent for asymmetric electrophilic amination of enolates. The aminated products were obtained in low diastereoselectivities of up to 21% d.e.
Publikováno v:
Tetrahedron Letters. 41:2247-2251
A range of 3-aryl-N-carboxamido oxaziridines have been prepared and tested as reagents for electrophilic amination of carbanions. The 3-(2-cyanophenyl)-derivative gave highest yields of amination product, and was used for amination of ketone, ester a
Publikováno v:
Tetrahedron Letters. 39:4913-4916
Benzoyl esters of propargylic alcohols can be prepared in an enantioselective manner by direct copper-catalysed acyloxylation of alkynes with t-butyl peroxybenzoate. High product yields and reasonable levels of induction are obtained upon the oxidati
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1167-1170
The oxidation of cyclic alkenes with peresters catalysed by copper complexes of bis-oxazolines, prepared from (1S,2R)-aminoindanol, affords acylated allylic alcohols in good yield and with good levels of enantiocontrol.
Autor:
Steven Swallow, Gary A. Molander
Publikováno v:
The Journal of Organic Chemistry. 59:7148-7151
Publikováno v:
Tetrahedron Letters. 34:8553-8556
Anionic species formed by treatment of vinyl sulfones with hydridoaluminates were trapped intramolecularly by esters to provide six- and seven-membered cyclic ketosulfones, e.g. I (R = Me, H, Ar = p-tolyl) and II, exemplified by the stereoselective c
Autor:
D. Neville Jones, Nicholas C. O. Tomkinson, Wood William Wakefield, Steven Swallow, Mark W. J. Maybury
Publikováno v:
Tetrahedron Letters. 42:2193-2195
A new approach to the synthesis of optically pure trans-perhydroazulenes and trans-hydrindanes using a homochiral sulfoxide auxiliary to control both chemical reactivity and enantioselectivity is described.