Prodrug thiamine analogs as inhibitors of the enzyme transketolase

Autor: Allen A. Thomas, Todd Romoff, Laura Hayter, Jed Pheneger, Jason De Meese, Patrice Lee, Boyd Steven A, S. Kirk Wright, Christine Lemieux, Gunawardana Indrani W, Steven S. Gonzales, Walter E. DeWolf, Francis X. Sullivan, Yvan Le Huerou, Jie Lin, Gregory K. Poch, May Han, Tomas Kaplan, Solly Weiler

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:505-508

Transketolase, a key enzyme in the pentose phosphate pathway, has been suggested as a target for inhibition in the treatment of cancer. Compound 5a ('N3'-pyridyl thiamine'; 3-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c52fc62ae58a00ee42cd9c0ad1223c8
https://doi.org/10.1016/j.bmcl.2007.11.100

Brain Functional Connectivity Mapping of Behavioral Flexibility in Rhesus Monkeys.

Autor: Grant KA; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon 97006 grantka@ohsu.edu.; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon 97239.; Portland Alcohol Research Center, Oregon Health & Science University, Portland, Oregon 97239., Newman N; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon 97006., Lynn C; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon 97006., Davenport C; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon 97006., Gonzales S; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon 97006., Cuzon Carlson VC; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon 97006.; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon 97239.; Portland Alcohol Research Center, Oregon Health & Science University, Portland, Oregon 97239., Kroenke CD; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon 97006.; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon 97239.; Advanced Imaging Research Center, Oregon Health & Science University, Portland, Oregon 97239.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2022 Jun 15; Vol. 42 (24), pp. 4867-4878. Date of Electronic Publication: 2022 May 12.

Time for a Drink? A Mathematical Model of Non-human Primate Alcohol Consumption.

Autor: Moore S; Department of Computer Science, Bioinformatics, Baylor University, Waco, TX, United States., Radunskaya A; Department of Mathematics, Pomona College, Claremont, CA, United States., Zollinger E; Department of Mathematics and Computer Science, St. Joseph's College, Brooklyn, NY, United States., Grant KA; Oregon Health & Science University, Portland, OR, United States., Gonzales S; Oregon Health & Science University, Portland, OR, United States., Baker EJ; Department of Computer Science, Bioinformatics, Baylor University, Waco, TX, United States.

Publikováno v: Frontiers in applied mathematics and statistics [Front Appl Math Stat] 2019 Feb; Vol. 5. Date of Electronic Publication: 2019 Feb 22.

Identifying Future Drinkers: Behavioral Analysis of Monkeys Initiating Drinking to Intoxication is Predictive of Future Drinking Classification.

Autor: Baker EJ; Department of Computer Science, Baylor University, Waco, Texas., Walter NA; Division of Neuroscience at the Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon., Salo A; Department of Computer Science, Baylor University, Waco, Texas., Rivas Perea P; Department of Computer Science, Marist College, Poughkeepsie, New York., Moore S; Department of Computer Science, Baylor University, Waco, Texas., Gonzales S; Division of Neuroscience at the Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon., Grant KA; Division of Neuroscience at the Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon.

Publikováno v: Alcoholism, clinical and experimental research [Alcohol Clin Exp Res] 2017 Mar; Vol. 41 (3), pp. 626-636. Date of Electronic Publication: 2017 Feb 16.