ATRT-22. Outcomes for children with recurrent atypical teratoid rhabdoid tumor: A single institution study with updated molecular and germline analysis

Autor: Steven S Carey, Jie Huang, Jason R Myers, Roya Mostafavi, Brent Orr, Layna H Michalik, Paul Klimo, Frederick Boop, Kim E Nichols, Thomas Merchant, David W Ellison, Giles W Robinson, Arzu Onar-Thomas, Amar Gajjar, Santhosh Upadhyaya

Publikováno v: Neuro-Oncology. 24:i8-i8

BACKGROUND: Children with recurrent atypical teratoid rhabdoid tumor (recATRT) who fail frontline therapies have dismal outcomes. The association of ATRT molecular groups (SHH, TYR and MYC) and presence of underlying cancer predisposition with surviv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2de657e2b163274f3b12ad76db569b7f
https://doi.org/10.1093/neuonc/noac079.021

Characterization, Treatment, and Outcome of Intracranial Neoplasms in the First 120 Days of Life

Autor: Alberto Broniscer, Jesse J. Jenkins, Frederick A. Boop, Heather M. Conklin, Karen Wright, Noah D. Sabin, Atmaram Pai-Panandiker, Amar Gajjar, Ibrahim Qaddoumi, Justin N. Baker, Steven S. Carey

Publikováno v: Journal of Child Neurology. 26:988-994

Little is known about brain tumors in early infancy. Investigators reviewed the records of 27 patients (12 boys and 15 girls) diagnosed within 120 days of birth. The median age was 66 days (range, 0-110 days) at diagnosis. All patients underwent surg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc08000192d2b8219edc99f804c70d2a
https://doi.org/10.1177/0883073811401398

Psorospermin structural requirements for P-glycoprotein resistance reversal

Autor: Steven S. Carey, Vijay Gokhale, Laurence H. Hurley, Mary Gleason-Guzman

Publikováno v: Molecular Cancer Therapeutics. 7:3617-3623

Resistance to chemotherapy reduces its effectiveness, resulting in increased mortality. Psorospermin, a natural product, is a topoisomerase II–directed DNA alkylating agent active against multidrug-resistant (MDR) cell lines, including multiple mye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f4d6d66b1a8d755bd9daef179e91cc
https://doi.org/10.1158/1535-7163.mct-08-0519

Time and dose-dependent radiosensitization of the glioblastoma multiforme U251 cells by the EGF receptor tyrosine kinase inhibitor ZD1839 ('Iressa')

Autor: Jesse D. Martinez, Ryan R. Falsey, Heather Glanzberg, Steven S. Carey, Baldassarre Stea, Aaron A. Ambrad, Jay Patel, Kerri L. Kislin, Emmanuelle J. Meuillet

Publikováno v: Cancer letters. 202(1)

Hyperactive epidermal growth factor receptor (EGFR) signaling, which promotes unregulated cell growth and inhibits apoptosis, is believed to contribute to clinical radiation resistance of glioblastoma multiforme (GBM). Blockage of the EGFR signalling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680d394b1429c675b8ad260a8951b480
https://pubmed.ncbi.nlm.nih.gov/14643025

Revised Minoan eruption volume as benchmark for large volcanic eruptions.

Autor: Karstens J; GEOMAR Helmholtz Centre for Ocean Research Kiel, Kiel, Germany. jkarstens@geomar.de., Preine J; University of Hamburg, Institute of Geophysics, Hamburg, Germany., Crutchley GJ; GEOMAR Helmholtz Centre for Ocean Research Kiel, Kiel, Germany., Kutterolf S; GEOMAR Helmholtz Centre for Ocean Research Kiel, Kiel, Germany., van der Bilt WGM; Department of Earth Science and Bjerknes Centre for Climate Research, University of Bergen, Bergen, Norway., Hooft EEE; Department of Earth Science, University of Oregon, Eugene, OR, USA., Druitt TH; Laboratoire Magmas et Volcans, Université Clermont Auvergne, OPGC, CNRS, IRD, F-63000, Clermont-Ferrand, France., Schmid F; GEOMAR Helmholtz Centre for Ocean Research Kiel, Kiel, Germany.; K.U.M Umwelt und Meerestechnik Kiel GmbH, Kiel, Germany., Cederstrøm JM; Department of Earth Science and Bjerknes Centre for Climate Research, University of Bergen, Bergen, Norway., Hübscher C; University of Hamburg, Institute of Geophysics, Hamburg, Germany., Nomikou P; National and Kapodistrian University of Athens, Department of Geology and Geoenvironment, Athens, Greece., Carey S; University of Rhode Island, Kingston, RI, USA., Kühn M; GEOMAR Helmholtz Centre for Ocean Research Kiel, Kiel, Germany., Elger J; GEOMAR Helmholtz Centre for Ocean Research Kiel, Kiel, Germany., Berndt C; GEOMAR Helmholtz Centre for Ocean Research Kiel, Kiel, Germany.

Publikováno v: Nature communications [Nat Commun] 2023 Apr 29; Vol. 14 (1), pp. 2497. Date of Electronic Publication: 2023 Apr 29.