Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Steven S Henry"'
Autor:
Frances Lu, Bryan G. Johnson, Daniel Ursu, Joan H. Carter, Lisa M. Broad, Kofi Adragni, Shane Atwell, Jing Wang, David K. Clawson, Beverly A. Heinz, Steven P. Swanson, James A. Monn, Qi Chen, Helene E. Sanger, David B. Shaw, Steven Marc Massey, Xushan Wang, Marijane Russell, Steven S. Henry, Junliang Hao, Rajni M. Bhardwaj, Diseroad Benjamin Alan, David L. McKinzie, Brian G. Getman, John T. Catlow
Publikováno v:
Journal of Medicinal Chemistry. 61:2303-2328
Multiple therapeutic opportunities have been suggested for compounds capable of selective activation of metabotropic glutamate 3 (mGlu3) receptors, but small molecule tools are lacking. As part of our ongoing efforts to identify potent, selective, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34fd3a986aac486e41e6ea738f1a4465
https://doi.org/10.1021/acs.jmedchem.7b01481
https://doi.org/10.1021/acs.jmedchem.7b01481
Autor:
James A, Monn, Steven S, Henry, Steven M, Massey, David K, Clawson, Qi, Chen, Benjamin A, Diseroad, Rajni M, Bhardwaj, Shane, Atwell, Frances, Lu, Jing, Wang, Marijane, Russell, Beverly A, Heinz, Xu-Shan, Wang, Joan H, Carter, Brian G, Getman, Kofi, Adragni, Lisa M, Broad, Helene E, Sanger, Daniel, Ursu, John T, Catlow, Steven, Swanson, Bryan G, Johnson, David B, Shaw, David L, McKinzie, Junliang, Hao
Publikováno v:
Journal of medicinal chemistry. 61(6)
Multiple therapeutic opportunities have been suggested for compounds capable of selective activation of metabotropic glutamate 3 (mGlu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b0a91b923b376e1620dd4223a841b23
https://pubmed.ncbi.nlm.nih.gov/29350927
https://pubmed.ncbi.nlm.nih.gov/29350927
Autor:
Mark G. Bures, David Edward Tupper, Joan H. Carter, James A. Monn, David L. McKinzie, Marijane Russell, Lourdes Prieto, Steven S. Henry, Reinhard Matthew Robert, Alicia Marcos, Lesley Walton, Christopher David Beadle, Bryan G. Johnson, Brian G. Getman, John T. Catlow, Frances Lu, Xushan Wang, Lorena Taboada, S. Richard Baker, Beverly A. Heinz, Helene Rudyk, David B. Shaw, Jaime Blanco, Carlos Lamas, Steven Swanson, David K. Clawson, Junliang Hao, Carlos Montero, Teresa Man, Shane Atwell, Barry Peter Clark, Jing Wang
Publikováno v:
Journal of Medicinal Chemistry. 58:7526-7548
Identification of orthosteric mGlu(2/3) receptor agonists capable of discriminating between individual mGlu2 and mGlu3 subtypes has been highly challenging owing to the glutamate-site sequence homology between these proteins. Herein we detail the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13d4b305d2ec1acea2f3d473c73251c1
https://doi.org/10.1021/acs.jmedchem.5b01124
https://doi.org/10.1021/acs.jmedchem.5b01124
Autor:
Junliang Hao, Matt R. Reinhard, Barry Peter Clark, Jaime Blanco, Concepción Pedregal, Shane Atwell, Michael P. Johnson, Paul Goldsmith, Carlos Montero, Rosa Maria A. Simmons, James A. Monn, Steven Swanson, Chuanxi Xiang, Bryan G. Johnson, Frances Lu, Lorena Taboada, Teresa Man, David K. Clawson, Marijane Russell, Lesley Walton, Steven S. Henry, Jing Wang, Beverly A. Heinz, S. Richard Baker, Helen E. Sanger, Xushan Wang, David B. Shaw, Lourdes Prieto, Mark G. Bures, Joan H. Carter, Lisa M. Broad, Kelly L. Knopp, Helene Rudyk, David L. McKinzie, David Edward Tupper, Christopher David Beadle, John T. Catlow, Carlos Lamas, Alicia Marcos
Publikováno v:
Journal of Medicinal Chemistry. 58:1776-1794
As part of our ongoing research to identify novel agents acting at metabotropic glutamate 2 (mGlu2) and 3 (mGlu3) receptors, we have previously reported the identification of the C4α-methyl analog of mGlu2/3 receptor agonist 1 (LY354740). This molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::527bce29ceb86979086e1027b9d87633
https://doi.org/10.1021/jm501612y
https://doi.org/10.1021/jm501612y
Autor:
Reinhard Matthew Robert, James A. Monn, Bryan G. Johnson, Xushan Wang, Matthew John Valli, Beverly A. Heinz, Mark G. Bures, Steven S. Henry, Brian G. Getman, Joan H. Carter, John T. Catlow, Junliang Hao, David L. McKinzie, Steven Marc Massey, Marc Herin, Steven Swanson, Gregory A. Stephenson
Publikováno v:
Journal of Medicinal Chemistry. 56:4442-4455
As part of our ongoing interest in identifying novel agonists acting at metabotropic glutamate (mGlu) 2/3 receptors, we have explored the effect of structural modifications of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740), a po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252437b5f6b3182bbac062c1d85eb12a
https://doi.org/10.1021/jm4000165
https://doi.org/10.1021/jm4000165
Autor:
Bruce A. Dressman, Veronique Dehlinger, Rosa Maria A. Simmons, Smriti Iyengar, Steven Marc Massey, John T. Catlow, David L. McKinzie, Langu Peng, Adam M. Fivush, Edda F. Roberts, Barry Peter Clark, Mallorie R. Bracey-Walker, James A. Monn, Junliang Hao, Steven C. Peters, Steven S. Henry, Beverly A. Heinz, Sean P. Hollinshead, Anita D. Tepool, Steven Swanson, Patrick L. Love, Thomas C. Britton, Helene Rudyk, Benjamin Paul Vokits
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1249-1252
A novel series of selective negative allosteric modulators (NAMs) for metabotropic glutamate receptor 5 (mGlu5) was discovered from an isothiazole scaffold. One compound of this series, (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef86f59bea2ecb1e4670f9d5e462c59f
https://doi.org/10.1016/j.bmcl.2013.01.009
https://doi.org/10.1016/j.bmcl.2013.01.009
Improved Synthesis of C4α- and C4β-Methyl Analogues of 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate
Autor:
J. Craig Ruble, James A. Monn, Dana L. T. Laird, Molly D. Brady, Steven S. Henry, Varie David Lee
Publikováno v:
Organic Letters. 14:2662-2665
An efficient and divergent synthesis of C4α- and C4β-methyl-substituted analogues of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate, which are important tools in the study of metabotropic glutamate receptor function, has been achieved. By taking adv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265a24241d2fe818d7307de993832333
https://doi.org/10.1021/ol300516y
https://doi.org/10.1021/ol300516y
Autor:
James A, Monn, Lourdes, Prieto, Lorena, Taboada, Junliang, Hao, Matthew R, Reinhard, Steven S, Henry, Christopher D, Beadle, Lesley, Walton, Teresa, Man, Helene, Rudyk, Barry, Clark, David, Tupper, S Richard, Baker, Carlos, Lamas, Carlos, Montero, Alicia, Marcos, Jaime, Blanco, Mark, Bures, David K, Clawson, Shane, Atwell, Frances, Lu, Jing, Wang, Marijane, Russell, Beverly A, Heinz, Xushan, Wang, Joan H, Carter, Brian G, Getman, John T, Catlow, Steven, Swanson, Bryan G, Johnson, David B, Shaw, David L, McKinzie
Publikováno v:
Journal of medicinal chemistry. 58(18)
Identification of orthosteric mGlu(2/3) receptor agonists capable of discriminating between individual mGlu2 and mGlu3 subtypes has been highly challenging owing to the glutamate-site sequence homology between these proteins. Herein we detail the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3e08f0001b2fb8da6ecccee3a121fe3
https://pubmed.ncbi.nlm.nih.gov/26313429
https://pubmed.ncbi.nlm.nih.gov/26313429
Autor:
James A, Monn, Lourdes, Prieto, Lorena, Taboada, Concepcion, Pedregal, Junliang, Hao, Matt R, Reinhard, Steven S, Henry, Paul J, Goldsmith, Christopher D, Beadle, Lesley, Walton, Teresa, Man, Helene, Rudyk, Barry, Clark, David, Tupper, S Richard, Baker, Carlos, Lamas, Carlos, Montero, Alicia, Marcos, Jaime, Blanco, Mark, Bures, David K, Clawson, Shane, Atwell, Frances, Lu, Jing, Wang, Marijane, Russell, Beverly A, Heinz, Xushan, Wang, Joan H, Carter, Chuanxi, Xiang, John T, Catlow, Steven, Swanson, Helen, Sanger, Lisa M, Broad, Michael P, Johnson, Kelly L, Knopp, Rosa M A, Simmons, Bryan G, Johnson, David B, Shaw, David L, McKinzie
Publikováno v:
Journal of medicinal chemistry. 58(4)
As part of our ongoing research to identify novel agents acting at metabotropic glutamate 2 (mGlu2) and 3 (mGlu3) receptors, we have previously reported the identification of the C4α-methyl analog of mGlu2/3 receptor agonist 1 (LY354740). This molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::257cce6d5aa3ab6ae8072e84e32e8018
https://pubmed.ncbi.nlm.nih.gov/25602126
https://pubmed.ncbi.nlm.nih.gov/25602126
Autor:
Sherri L. Andis, Steven S. Henry, Darryle D. Schoepp, Deborah D. Giera, Rebecca A. Wright, and Ann E. Kingston, Marc Herin, Gregory A. Stephenson, Bryan G. Johnson, Steven Marc Massey, John T. Catlow, Mark G. Bures, Matthew John Valli, James A. Monn
Publikováno v:
Journal of Medicinal Chemistry. 50:233-240
(-)-4-Amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate (LY389795, (-)-3) is a highly potent and selective agonist of metabotropic glutamate receptors 2 (mGlu2) and 3 (mGlu3). As part of our ongoing research program, we have prepared S-oxidized var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ee56b6f2c7ef0b15c22370c0370c5a
https://doi.org/10.1021/jm060917u
https://doi.org/10.1021/jm060917u