Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Steven S, Good"'
Autor:
Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S. Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, François Ferron, Bruno Canard
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The drug AT-527 targets the SARS-CoV-2 replication machinery. Here the authors use Cryo-EM to show how AT-527 inhibits SARS-CoV-2 polymerase by acting as an immediate RNA chain terminator and stably binding in a NiRAN active-site pocket; impeding an
Externí odkaz:
https://doaj.org/article/10c0996a692f427a8bc1883d8ce5e61e
Autor:
Kai Lin, Steven S Good, Justin G Julander, Abbie E Weight, Adel Moussa, Jean-Pierre Sommadossi
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 1, p e0009937 (2022)
Yellow fever virus (YFV) is a zoonotic pathogen re-emerging in parts of the world, causing a viral hemorrhagic fever associated with high mortality rates. While an effective vaccine is available, having an effective antiviral against YFV is critical
Externí odkaz:
https://doaj.org/article/8ed7f16b143b4c3195cab3f38bd25777
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227104 (2020)
Despite the availability of highly effective direct-acting antiviral (DAA) regimens for the treatment of hepatitis C virus (HCV) infections, sustained viral response (SVR) rates remain suboptimal for difficult-to-treat patient populations such as tho
Externí odkaz:
https://doaj.org/article/1fb5fce391574e2f9af8b9cc3d21e6da
Autor:
Jean-Pierre Sommadossi, Steven S. Good, Adel Moussa, Justin G. Julander, Abbie Weight, Kai Lin
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 1, p e0009937 (2022)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Yellow fever virus (YFV) is a zoonotic pathogen re-emerging in parts of the world, causing a viral hemorrhagic fever associated with high mortality rates. While an effective vaccine is available, having an effective antiviral against YFV is critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b66f36fe30e882a326309e5a3a2193
https://doaj.org/article/8ed7f16b143b4c3195cab3f38bd25777
https://doaj.org/article/8ed7f16b143b4c3195cab3f38bd25777
Autor:
Steven S. Good, Kai Lin, Gabriella Collu, Ashleigh Shannon, Bruno Canard, Paolo La Colla, Adel Moussa, Justin G. Julander, Jean-Pierre Sommadossi
Publikováno v:
Antimicrobial Agents and Chemotherapy
Every year, millions of people worldwide are infected with dengue virus (DENV), with a significant number developing severe life-threatening disease. There are currently no broadly indicated vaccines or therapeutics available for treatment of DENV in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea713249c1156d73c52fb93d5a123c5
http://europepmc.org/articles/PMC8522752
http://europepmc.org/articles/PMC8522752
Autor:
Bhawna Sama, Etienne Decroly, Paolo La Colla, Barbara Selisko, Steven S. Good, Jean-Pierre Sommadossi, Adrien Delpal, Camille Falcou, Adel Moussa, Kai Lin, Hui Shi, Ashleigh Shannon, Bruno Canard, Cécilia Eydoux, Yingxao Zhu, Karine Alvarez, Pierre Gauffre, Xiaodong Yan, Veronique Fattorini, Priscila El-Kazzi, Mikael Feracci, François Ferron, Jean-Claude Guillemot
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Nature Communications
Nature Communications, 2022, 13, ⟨10.1038/s41467-022-28113-1⟩
Nature Communications
Nature Communications, 2022, 13, ⟨10.1038/s41467-022-28113-1⟩
A worldwide effort is ongoing to discover drugs against the Severe Acute Respiratory Syndrome coronavirus type 2 (SARS-CoV-2), which has so far caused >3.5 million fatalities (https://covid19.who.int/). The virus essential RNA-dependent RNA polymeras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14f01f1609abb1a795a7309150f5ca4
https://doi.org/10.21203/rs.3.rs-624370/v1
https://doi.org/10.21203/rs.3.rs-624370/v1
Autor:
Kai Lin, Etienne Decroly, Françoise Debart, Nadia Rabah, Bhawna Sama, Jean-Claude Guillemot, Bruno Canard, Hui Shi, Ashleigh Shannon, Cécilia Eydoux, Jean-Jacques Vasseur, Yingxiao Zhu, François Ferron, Camille Falcou, Mikael Feracci, A. Moussa, Jean-Pierre Sommadossi, Karine Toulon, Barbara Selisko, Mathieu Noël, Steven S. Good, Pierre Gauffre, Priscila El Kazzi, Xiaodong Yan, Veronique Fattorini
SummaryHow viruses from the Coronaviridae family initiate viral RNA synthesis is unknown. Here we show that the SARS-CoV-1 and −2 Nidovirus RdRp-Associated Nucleotidyltransferase (NiRAN) domain on nsp12 uridylates the viral cofactor nsp8, forming a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e1d77f43ab95d6f58607895a539c39
https://doi.org/10.1101/2021.03.23.436564
https://doi.org/10.1101/2021.03.23.436564
Autor:
Jonna B. Westover, X.J. Zhou, Gabriella Collu, Jean Pierre Sommadossi, Bruno Canard, Steven S. Good, A. Moussa, Paolo La Colla, Kie Hoon Jung
Publikováno v:
Antimicrobial Agents and Chemotherapy
The impact of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19, is global and unprecedented. Although remdesivir has recently been approved by the FDA to treat SARS-CoV-2 infection, no oral antiviral is av
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bacbfe6df2007853ed23872161eed46
https://doi.org/10.1128/aac.02479-20
https://doi.org/10.1128/aac.02479-20
Autor:
Steven S, Good, Jonna, Westover, Kie Hoon, Jung, Xiao-Jian, Zhou, Adel, Moussa, Paolo, La Colla, Gabriella, Collu, Bruno, Canard, Jean-Pierre, Sommadossi
Publikováno v:
Antimicrobial Agents and Chemotherapy
The impact of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19, is global and unprecedented. Although remdesivir has recently been approved by the FDA to treat SARS-CoV-2 infection, no oral antiviral is av
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b769c49dbcec6b24d3219b74738b52d6
https://pubmed.ncbi.nlm.nih.gov/33558299
https://pubmed.ncbi.nlm.nih.gov/33558299
Autor:
Gabriella Collu, Jonna B. Westover, Adel Moussa, Steven S. Good, Paolo La Colla, Jean-Pierre Sommadossi, Bruno Canard, Kie Hoon Jung
AT-527, an orally administered double prodrug of a guanosine nucleotide analog, has been shown previously to be highly efficacious and well tolerated in HCV-infected subjects. Herein we report the potent in vitro activity of AT-511, the free base for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::999861132a49f5ac0158e0ebaeac09d9
https://doi.org/10.1101/2020.08.11.242834
https://doi.org/10.1101/2020.08.11.242834