Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Steven Rust"'
Autor:
Sophia K. Berry, Steven Rust, Lorraine Irving, Josefin Bartholdson Scott, Lucy A. Weinert, Gordon Dougan, Graham Christie, Paul Warrener, Ralph Minter, Andrew J. Grant
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT We used phage display, antibody engineering, and high-throughput assays to identify antibody-accessible targets of Klebsiella pneumoniae. We report the discovery of monoclonal antibodies (mAbs) binding to type 3 fimbrial proteins, including
Externí odkaz:
https://doaj.org/article/95aa0fb605154b428c64e9bc9b28abc5
Autor:
Sophia K. Berry, Steven Rust, Carolina Caceres, Lorraine Irving, Josefin Bartholdson Scott, David E. Tabor, Gordon Dougan, Graham Christie, Paul Warrener, Ralph Minter, Andrew J. Grant
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
The increasing global occurrence of recalcitrant multi-drug resistant Klebsiella pneumoniae infections warrants the investigation of alternative therapy options, such as the use of monoclonal antibodies (mAbs). We used a target-agnostic phage display
Externí odkaz:
https://doaj.org/article/f5b2bd62c6a24a919b1bf35d4d9e5d1d
Autor:
Olivia J. S. Macleod, Jean-Mathieu Bart, Paula MacGregor, Lori Peacock, Nicholas J. Savill, Svenja Hester, Sophie Ravel, Jack D. Sunter, Camilla Trevor, Steven Rust, Tristan J. Vaughan, Ralph Minter, Shabaz Mohammed, Wendy Gibson, Martin C. Taylor, Matthew K. Higgins, Mark Carrington
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
African trypanosome infections can persist for years, but immune evasion mechanisms are not fully understood. Here, Macleod et al. identify a trypanosome receptor for mammalian factor H, a negative regulator of the alternative complement pathway, tha
Externí odkaz:
https://doaj.org/article/26bfcfd0e9cc483dae71e8f47f88e8ec
Autor:
Karla Vasco, Brian Nohomovich, Pallavi Singh, Cristina Venegas-Vargas, Rebekah E. Mosci, Steven Rust, Paul Bartlett, Bo Norby, Daniel Grooms, Lixin Zhang, Shannon D. Manning
Publikováno v:
Microorganisms, Vol 9, Iss 8, p 1737 (2021)
Cattle are the main reservoirs of Shiga toxin producing Escherichia coli (STEC), a major foodborne pathogen associated with acute enteric disease and hemolytic–uremic syndrome in humans. A total of 397 beef and dairy cattle from 5 farms were includ
Externí odkaz:
https://doaj.org/article/b553b7fc3e034491926b92208c922fcd
Autor:
Paula MacGregor, Andrea L Gonzalez-Munoz, Fatoumatta Jobe, Martin C Taylor, Steven Rust, Alan M Sandercock, Olivia J S Macleod, Katrien Van Bocxlaer, Amanda F Francisco, Francois D'Hooge, Arnaud Tiberghien, Conor S Barry, Philip Howard, Matthew K Higgins, Tristan J Vaughan, Ralph Minter, Mark Carrington
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007373 (2019)
Infections of humans and livestock with African trypanosomes are treated with drugs introduced decades ago that are not always fully effective and often have severe side effects. Here, the trypanosome haptoglobin-haemoglobin receptor (HpHbR) has been
Externí odkaz:
https://doaj.org/article/78f44b97ff384aeaad7bf4d99e7e1faf
Autor:
Lori Peacock, Olivia J. S. Macleod, Jean-Mathieu Bart, Sophie Ravel, Svenja Hester, Martin C. Taylor, Camilla Trevor, Ralph Minter, Jack D. Sunter, Tristan J. Vaughan, Wendy Gibson, Paula MacGregor, Steven Rust, Matthew K. Higgins, Shabaz Mohammed, Mark Carrington, Nicholas J. Savill
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Macleod, O J S, Bart, J M, MacGregor, P, Peacock, L, Savill, N J, Hester, S, Ravel, S, Sunter, J D, Trevor, C, Rust, S, Vaughan, T J, Minter, R, Mohammed, S, Gibson, W, Taylor, M C, Higgins, M K & Carrington, M 2020, ' A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies ', Nature Communications, vol. 11, no. 1, 1326 . https://doi.org/10.1038/s41467-020-15125-y
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11, art. 1326 [12 p.]. ⟨10.1038/s41467-020-15125-y⟩
Macleod, O J S, Bart, J-M, Macgregor, P, Peacock, L, Hester, S, Ravel, S, Sunter, J D, Trevor, C, Rust, S, Vaughan, T J, Minter, R, Mohammed, S, Gibson, W, Taylor, M C, Higgins, M K & Carrington, M 2020, ' A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies ', Nature Communications, vol. 11, 1326 (2020) . https://doi.org/10.1038/s41467-020-15125-y
Macleod, O J S, Bart, J M, MacGregor, P, Peacock, L, Savill, N J, Hester, S, Ravel, S, Sunter, J D, Trevor, C, Rust, S, Vaughan, T J, Minter, R, Mohammed, S, Gibson, W, Taylor, M C, Higgins, M K & Carrington, M 2020, ' A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies ', Nature Communications, vol. 11, no. 1, 1326 . https://doi.org/10.1038/s41467-020-15125-y
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11, art. 1326 [12 p.]. ⟨10.1038/s41467-020-15125-y⟩
Macleod, O J S, Bart, J-M, Macgregor, P, Peacock, L, Hester, S, Ravel, S, Sunter, J D, Trevor, C, Rust, S, Vaughan, T J, Minter, R, Mohammed, S, Gibson, W, Taylor, M C, Higgins, M K & Carrington, M 2020, ' A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies ', Nature Communications, vol. 11, 1326 (2020) . https://doi.org/10.1038/s41467-020-15125-y
Persistent pathogens have evolved to avoid elimination by the mammalian immune system including mechanisms to evade complement. Infections with African trypanosomes can persist for years and cause human and animal disease throughout sub-Saharan Afric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d67987dc434dc81572261c646a5450
https://doaj.org/article/26bfcfd0e9cc483dae71e8f47f88e8ec
https://doaj.org/article/26bfcfd0e9cc483dae71e8f47f88e8ec
Autor:
Sophia K, Berry, Steven, Rust, Carolina, Caceres, Lorraine, Irving, Josefin, Bartholdson Scott, David E, Tabor, Gordon, Dougan, Graham, Christie, Paul, Warrener, Ralph, Minter, Andrew J, Grant
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The increasing global occurrence of recalcitrant multi-drug resistant Klebsiella pneumoniae infections warrants the investigation of alternative therapy options, such as the use of monoclonal antibodies (mAbs). We used a target-agnostic phage display
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db63f1468dccdec106edcc027948041b
https://pubmed.ncbi.nlm.nih.gov/34923908
https://pubmed.ncbi.nlm.nih.gov/34923908
Publikováno v:
Phenotypic Drug Discovery ISBN: 9781788018760
Phenotypic antibody drug discovery, which takes a target-agnostic approach, remains an under-utilised strategy in an industry where target-led antibody drug discovery is dominant. However, there are strong arguments in support of the phenotypic appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9515643b56013c5ab0d31bf01cd45e42
https://doi.org/10.1039/9781839160721-00160
https://doi.org/10.1039/9781839160721-00160
Publikováno v:
Ocean & Coastal Management. 215:105966
Assessing seafood supply chains is important at both individual business and industry levels to ensure profitability, efficiency, and consumer satisfaction. Such assessments are typically aimed at understanding the structure of the supply network and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b90facbc37e7956975193b740027b9c9
https://doi.org/10.1016/j.ocecoaman.2021.105966
https://doi.org/10.1016/j.ocecoaman.2021.105966
Autor:
Steven Rust, Megan Star
Publikováno v:
Australasian Journal of Environmental Management. 25:233-247
Grazing in the Fitzroy region has reduced ground cover and increased the exposure of erosion features to terrestrial water flows, resulting in gullies. The run-off that results from such soil degra...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6dffe9ed988c2f8f09f881fe43615e9
https://doi.org/10.1080/14486563.2017.1393465
https://doi.org/10.1080/14486563.2017.1393465