Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Steven Raynard"'
Publikováno v:
Journal of Biological Chemistry. 288:14221-14227
The conserved BTR complex, composed of the Bloom's syndrome helicase (BLM), topoisomerase IIIα, RMI1, and RMI2, regulates homologous recombination in favor of non-crossover formation via the dissolution of the double Holliday Junction (dHJ). Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9160052a7b8af7efc4dcc23db654e3f
https://doi.org/10.1074/jbc.m113.465609
https://doi.org/10.1074/jbc.m113.465609
Publikováno v:
Genes & Development. 22:2903-2907
A key cellular response to DNA double-strand breaks (DSBs) is 5'-to-3' DSB resection by nucleases to generate regions of ssDNA that then trigger cell cycle checkpoint signaling and DSB repair by homologous recombination (HR). Here, we reveal that in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e145b2f7d37656381229c85ebbc72fa
https://doi.org/10.1101/gad.1742408
https://doi.org/10.1101/gad.1742408
Autor:
Paul R. Andreassen, Qiang Fan, Amom Ruhikanta Meetei, Valeria Busygina, Patrick Sung, Chang hu Du, Thiyam Ramsing Singh, Abdullah Mahmood Ali, Steven Raynard
Publikováno v:
Genes & Development. 22:2856-2868
Bloom Syndrome is an autosomal recessive cancer-prone disorder caused by mutations in the BLM gene. BLM encodes a DNA helicase of the RECQ family, and associates with Topo IIIα and BLAP75/RMI1 (BLAP for BLM-associated polypeptide/RecQ-mediated genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f09f1714abdba730bd13b5f0bf695da
https://doi.org/10.1101/gad.1725108
https://doi.org/10.1101/gad.1725108
Publikováno v:
Journal of Biological Chemistry. 282:31484-31492
BLM, the protein mutated in Bloom's syndrome, possesses a helicase activity that can dissociate DNA structures, including the Holliday junction, expected to arise during homologous recombination. BLM is stably associated with topoisomerase IIIalpha (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20cd1645c38052861ce3e8db7fbeac4
https://doi.org/10.1074/jbc.m706116200
https://doi.org/10.1074/jbc.m706116200
Publikováno v:
Journal of Biological Chemistry. 281:13861-13864
Bloom syndrome (BS), an autosomal recessive disorder, is marked by a high incidence of cancer early in life. Cells derived from BS patients are unstable genetically and exhibit frequent sister chromatid exchanges, reflective of homologous recombinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9298e0bb1a688348f72478e860f797
https://doi.org/10.1074/jbc.c600051200
https://doi.org/10.1074/jbc.c600051200
Autor:
Anita Cheng, Radhakrishnan Kanagaraj, Sybille Schwendener, Igor Shevelev, Shreya Paliwal, Patrick Sung, Pavel Janscak, Jeremy M. Stark, Steven Raynard
Publikováno v:
The Journal of biological chemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Homologous recombination (HR) provides an efficient mechanism for error-free repair of DNA double-strand breaks (DSBs). However, HR can be also harmful as inappropriate or untimely HR events can give rise to lethal recombination intermediates and chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7056757872512503ede7a38d04447298
https://doi.org/10.5167/uzh-34123
https://doi.org/10.5167/uzh-34123
Publikováno v:
Genesdevelopment. 23(13)
The resection of DNA double-strand breaks (DSBs) in bacteria is a motor-driven process performed by a multisubunit helicase–nuclease complex: either an Escherichia coli-type RecBCD enzyme or a Bacillus-type AddAB enzyme. Here we identify mycobacter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9c6897bc67209950e4079024f9186d
https://pubmed.ncbi.nlm.nih.gov/19470566
https://pubmed.ncbi.nlm.nih.gov/19470566
Autor:
Guangbin Luo, Steven Raynard, Xincheng Lu, Lu Zheng, Yiduo Hu, Maria Jasin, Ellen Barnes, Pavel Janscak, Patrick Sung, Peter Chi, Michael G. Sehorn, Jeremy M. Stark, Hannes Vogel, Wendy Bussen
Members of the RecQ helicase family play critical roles in genome maintenance. There are five RecQ homologs in mammals, and defects in three of these (BLM, WRN, and RECQL4) give rise to cancer predisposition syndromes in humans. RECQL and RECQL5 have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbef6e222d6734fb86119313682e071f
https://www.zora.uzh.ch/id/eprint/34908/
https://www.zora.uzh.ch/id/eprint/34908/
Autor:
Patrick Sung, Steven Raynard
Publikováno v:
Cold Spring Harbor Protocols. 2009:pdb.prot5120
INTRODUCTIONHomologous recombination is an important mechanism for the repair of damaged chromosomes, for preventing the demise of damaged replication forks, and for several other aspects of chromosome metabolism and maintenance. The homologous recom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84cfb14cf492c1b11e6b0384ffa67f3
https://doi.org/10.1101/pdb.prot5120
https://doi.org/10.1101/pdb.prot5120