Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Steven R. Whittaker"'
Autor:
Priya Sriskandarajah, Alexis De Haven Brandon, Kenneth MacLeod, Neil O. Carragher, Vladimir Kirkin, Martin Kaiser, Steven R. Whittaker
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
Abstract Background Multiple myeloma (MM) remains incurable despite recent therapeutic advances. RAS mutations are frequently associated with relapsed/refractory disease. Efforts to target the mitogen-activated protein kinase (MAPK) pathway with the
Externí odkaz:
https://doaj.org/article/87d98533f87749f780cf3deed309028f
Autor:
Walid Al-Akkad, Pilar Acedo, Maria-Giovanna Vilia, Luca Frenguelli, Alexander Ney, Irene Rodriguez-Hernandez, Peter L. Labib, Domenico Tamburrino, Gabriele Spoletini, Andrew R. Hall, Simone Canestrari, Anna Osnato, Jose Garcia-Bernardo, Leinal Sejour, Vessela Vassileva, Ioannis S. Vlachos, Giuseppe Fusai, Tu Vinh Luong, Steven R. Whittaker, Stephen P. Pereira, Ludovic Vallier, Massimo Pinzani, Krista Rombouts, Giuseppe Mazza
Publikováno v:
Cells, Vol 11, Iss 22, p 3652 (2022)
Over 80% of patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed at a late stage and are locally advanced or with concurrent metastases. The aggressive phenotype and relative chemo- and radiotherapeutic resistance of PDAC is thought to
Externí odkaz:
https://doaj.org/article/03368650ab844837a4a20c475e068208
Autor:
Steven R. Whittaker, Clare Barlow, Mathew P. Martin, Caterina Mancusi, Steve Wagner, Annette Self, Elaine Barrie, Robert Te Poele, Swee Sharp, Nathan Brown, Stuart Wilson, Wayne Jackson, Peter M. Fischer, Paul A. Clarke, Michael I. Walton, Edward McDonald, Julian Blagg, Martin Noble, Michelle D. Garrett, Paul Workman
Publikováno v:
Molecular Oncology, Vol 12, Iss 3, Pp 287-304 (2018)
Deregulation of the cyclin‐dependent kinases (CDKs) has been implicated in the pathogenesis of multiple cancer types. Consequently, CDKs have garnered intense interest as therapeutic targets for the treatment of cancer. We describe herein the molec
Externí odkaz:
https://doaj.org/article/fe1e3db27bb44f2e82c1a7b2ffc32006
Through the use of an unbiased, genome-scale CRISPR modifier screen, we identified NF1 suppression as a mechanism of resistance to EGFR inhibition in NRAS/KRAS/BRAFV600-wild-type colorectal cancer cells. Reduced NF1 expression permitted sustained sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c51c6e0d26324097fe0168eae979d2
https://doi.org/10.1158/1541-7786.c.6541428.v1
https://doi.org/10.1158/1541-7786.c.6541428.v1
Figure S3. Representation of sgRNAs targeting the 2nd, 3rd and 4th-ranked genes across the CRISPR screening arms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b004e1c654891ef325f2b8c34983a9
https://doi.org/10.1158/1541-7786.22516635.v1
https://doi.org/10.1158/1541-7786.22516635.v1
Table S2. Details of sgRNAs used in this study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da1b31bcc7fc3d74a638d7768ee1134
https://doi.org/10.1158/1541-7786.22516617
https://doi.org/10.1158/1541-7786.22516617
Autor:
Levi A. Garraway, David E. Root, Flora Luo, Steve Wagner, Glenn S. Cowley, Steven R. Whittaker
RAF and MEK inhibitors are effective in BRAF-mutant melanoma but not in BRAF-mutant colorectal cancer. To gain additional insights into this difference, we performed a genome-scale pooled shRNA enhancer screen in a BRAF-mutant, RAF inhibitor–resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::800a362e1a5f12e2e3e01375aeed7dc0
https://doi.org/10.1158/1535-7163.c.6536584.v1
https://doi.org/10.1158/1535-7163.c.6536584.v1
Autor:
Levi A. Garraway, David E. Root, Dirk Schadendorf, Glenn S. Cowley, Jessica Hsiao, Nikhil Wagle, Eliezer Van Allen, Jean-Philippe Theurillat, Steven R. Whittaker
Supplementary Table 1 XLS file - 1881K, Ranking of genes enriched in the presence of PLX4720 compared to DMSO controls. PDF (17837KB) Source File (XLSX) 1881KB Using Gene-E and the RIGER algorithm, genes were ranked according to the 2nd-best shRNA cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e0753828e04fbf280a7d22dd023f5c
https://doi.org/10.1158/2159-8290.22528575
https://doi.org/10.1158/2159-8290.22528575
Autor:
Levi A. Garraway, David E. Root, Dirk Schadendorf, Glenn S. Cowley, Jessica Hsiao, Nikhil Wagle, Eliezer Van Allen, Jean-Philippe Theurillat, Steven R. Whittaker
Supplementary Figure 2 PDF file - 45K, Resistance to the MEK inhibitor AZD6244 induced by loss of NF1 is reversed by combined suppression of C-RAF by RNA interference. A375 cells were infected with the indicated shRNAs and then exposed to a 10-point
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fa443bb068e7b6b937a3968c3e1819
https://doi.org/10.1158/2159-8290.22528584.v1
https://doi.org/10.1158/2159-8290.22528584.v1
Autor:
Levi A. Garraway, David E. Root, Flora Luo, Steve Wagner, Glenn S. Cowley, Steven R. Whittaker
Figure S1: Following BRAF inhibition, recovery of ERK phosphorylation is observed and RKO cells continue to proliferate in the presence of PLX4720. Figure S2: DAPPLE analysis of the top 300 candidate genes from the primary screen identifies potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d670865b3e6063080abfdde05b4ad9e
https://doi.org/10.1158/1535-7163.22500832.v1
https://doi.org/10.1158/1535-7163.22500832.v1