Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Steven R. Vincent"'
Publikováno v:
Synapse. 64:460-466
Nitric oxide (NO) acts in the nervous system to activate guanylyl cyclase and increase cGMP. One target for cGMP appears to be the cGMP-stimulated phosphodiesterase (PDE2A), which is widely expressed in the brain and provides a molecular mechanism fo
Autor:
Ziyi Liu, Steven R. Vincent, Hongkuan Yang, Mingchun Yang, Hongpeng Guan, Daijiro Yanagisawa, Ikuo Tooyama, Shiguang Zhao, Shigeko Takeuchi
Publikováno v:
Journal of Alzheimer's disease : JAD. 45(3)
Studies have shown an increased expression of mitochondrial ferritin (FtMt) and an antioxidant role for the protein in the brains of Alzheimer's disease (AD) patients. However, little information is available concerning the role of FtMt in other AD p
Publikováno v:
Experimental Neurology. 190:446-455
The endothelial cells (EC) of the microvasculature in the brain form the anatomical basis of the blood-brain barrier (BBB). In the present study, the effects of agents that modify the permeability of a well-established in vitro model of the human BBB
Publikováno v:
Biochemical and Biophysical Research Communications. 323:142-148
The hypothesis that the NO/cGMP pathway modulates PMN adhesion to human brain microvessel endothelial cells (HBMEC) was examined. Human PMN were incubated with resting or TNF-α-treated endothelial monolayers, and adhesion was quantified by light mic
Publikováno v:
Journal of Neurochemistry. 64:2814-2817
We applied reverse transcription-PCR to examine the gene expression of cyclic GMP (cGMP)-dependent protein kinase in the rat brain. A PCR product with the size predicted from the type II cGMP-dependent protein kinase (cGK II) cDNA was detected in var
Publikováno v:
Acta Histochemica et Cytochemica
The TRK-fused gene (TFG) was originally identified in chromosome translocation events, creating a pair of oncogenes in some cancers, and was recently demonstrated as the causal gene of hereditary motor and sensory neuropathy with proximal dominant in
Publikováno v:
Genomics. 71:363-367
We have recently identified a novel RING finger protein expressed in the rat brain, which associates with myosin V and α-actinin-4. Here we have cloned and characterized the orthologous human BERP cDNA and gene (HGMW-approved symbol RNF22). The huma
Publikováno v:
Biochemical and Biophysical Research Communications. 279:482-486
The RING finger domain occurs in a wide variety of proteins involved in cellular regulation. The polymerase chain reaction was used to search for novel RING finger proteins, using primers derived from expressed sequence tags (ests). A cDNA encoding a
Localization of the cGMP-dependent protein kinases in relation to nitric oxide synthase in the brain
Publikováno v:
Journal of Chemical Neuroanatomy. 17:45-55
The distributions of the type I and type II isoforms of cGMP-dependent protein kinase were determined in the rat brain using immunohistochemistry and in situ hybridization, and compared with the localization of NO synthase determined with NADPH-diaph
Publikováno v:
Neuropsychopharmacology. 19:133-145
The prototypical neuroleptic haloperidol and the atypical antipsychotic clozapine induce distinctly different patterns of c-fos expression in the forebrain. While haloperidol appears to increase c-fos expression via its D2 dopamine receptor antagonis