Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Steven R. Schneider"'
Autor:
Rebecca E. O’Connor, Steven R. Schneider, Denise Gautreau, Philip A. Carpino, Karen M. Ward, Jeffrey S. Lizano, John R. Hadcock, Philip A. Iredale, Dennis O. Scott, Robert L. Dow, Dawn Kelly-Sullivan
Publikováno v:
ACS Medicinal Chemistry Letters. 3:397-401
Antagonism of cannabinoid-1 (CB1) receptor signaling has been demonstrated to inhibit feeding behaviors in humans, but CB1-mediated central nervous system (CNS) side effects have halted the marketing and further development of the lead drugs against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdcaa646cbb776cb05d86c09e6ede88
https://doi.org/10.1021/ml3000325
https://doi.org/10.1021/ml3000325
Publikováno v:
Tetrahedron Letters. 52:5417-5420
This Letter describes the first report of a highly stereoselective synthesis of triethereal cyclohexanones via copper(I) mediated 1,4-addition of organometallic reagents to glucose-derived triethereal cyclohexenone. The cyclohexanones generated can b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fca3ea8417c251bebb79b5aac64d0b55
https://doi.org/10.1016/j.tetlet.2011.07.066
https://doi.org/10.1016/j.tetlet.2011.07.066
Autor:
Marlys Hammond, David A. Griffith, Philip A. Carpino, Steven R. Schneider, Robert L. Dow, Paul DaSilva-Jardine, John R. Hadcock, Philip A. Iredale, Dennis O. Scott, Ernest S. Paight
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5351-5354
A new series of CB(1) receptor antagonists incorporating an imidazole-based isosteric replacement for the hydrazide moiety of rimonabant (SR141716) is disclosed. Members of this imidazole series possess potent/selective binding to the rCB(1) receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fb2f93da026a0faa073ffb8e71095a
https://doi.org/10.1016/j.bmcl.2009.07.130
https://doi.org/10.1016/j.bmcl.2009.07.130
Autor:
Robert L. Dow, Paul DaSilva-Jardine, Ernest S. Paight, Philip A. Carpino, David A. Griffith, John R. Hadcock, Philip A. Iredale, Dennis O. Scott, Rebecca E. O’Connor, Chudy I. Nduaka, Shawn C Black, Steven R. Schneider
Publikováno v:
Journal of Medicinal Chemistry. 52:2652-2655
We report the design, synthesis, and structure-activity relationships of novel bicyclic lactam-based cannabinoid type 1 (CB(1)) receptor antagonists. Members of these series are potent, selective antagonists in in vitro/in vivo efficacy models of CB(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580a2e91a3010c35cb155a547b94543b
https://doi.org/10.1021/jm900255t
https://doi.org/10.1021/jm900255t
Autor:
Paul DaSilva-Jardine, Josephine Spitzer, Michele H. Rosner, Samuel P. Simons, Diane M. Hargrove, Boris A. Chrunyk, Richard F. Hank, Phoebe Chiang, Ernest S. Paight, Swick Andrew Gordon, Robert L. Dow, Peter Cornelius, Gayle K. Schulte, Tate Bonnie Frances, Steven R. Schneider, Terrell A. Patterson, William P. Newsome, Jayvardhan Pandit, Mark Ammirati, Eunsun Lee, Dennis E. Danley, Peter K. LeMotte
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:379-382
In this communication, we wish to describe the discovery of a novel series of 6-azauracil-based thyromimetics that possess up to 100-fold selectivities for binding and functional activation of the beta(1)-isoform of the thyroid receptor family. Struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eedc13a957ab620f44d6f0b2eb9b7bf1
https://doi.org/10.1016/s0960-894x(02)00947-2
https://doi.org/10.1016/s0960-894x(02)00947-2
Publikováno v:
SSRN Electronic Journal.
This article examines the alternative forms available to merging tax partnerships and reveals how the different forms can affect the tax consequences of the parties to such a transaction. In particular, the article illustrates how parties should choo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73c7d018b95f909a83331e791086a584
https://doi.org/10.2139/ssrn.2374026
https://doi.org/10.2139/ssrn.2374026
Autor:
Robert L. Dow, Steven R. Schneider
Publikováno v:
Journal of Heterocyclic Chemistry. 38:535-537
The 5,6,7,8-tetrahydro-1,7-naphthyridine (7) pharmacophore has the potential to serve as a confor-mationally-locked analog of the pharmacologically active 2-(3-pyridyl)ethylamine (1) core structure. This paper describes the synthesis of 5,6,7,8-tetra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::734a7e5a5581c0310cbf11f5c8936acf
https://doi.org/10.1002/jhet.5570380241
https://doi.org/10.1002/jhet.5570380241
Autor:
Steven R. Schneider, Robert L. Dow
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d25d8677682905f7344ad8aa55c54bf
https://doi.org/10.1002/chin.200135149
https://doi.org/10.1002/chin.200135149