Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Steven R. Hood"'
Autor:
Charlotte A. Ashby, Stephen E. Clarke, Andrew Ayrton, Sandra J. Baldwin, Lin Yue, Jo L. Bramhall, Steven R. Hood, Paul R. Murdock
Publikováno v:
Drug Metabolism and Disposition. 34:1063-1069
Drug-induced changes in expression of cytochrome P450 (P450) genes are a significant issue in the preclinical development of pharmaceuticals. For example, preclinically, P450 induction can affect safety studies by reducing the systemic exposure of a
Publikováno v:
Toxicology and applied pharmacology. 209(2)
The pregnane X receptor (PXR) mediates the induction of enzymes involved in steroid metabolism and xenobiotic detoxification. The receptor is expressed in liver and intestinal tissues and is activated by a wide range of compounds. The ability of a di
Publikováno v:
Toxicology Letters. 221:S42
Autor:
Gilbert R. Park, M. K. Bayliss, Cosette J. Serabjit-Singh, Deborah Herriott, Michael H. Tarbit, Steven R. Hood, Julie L. Hutson
Publikováno v:
Biochemical Society transactions. 21(4)