Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Steven R, Woodcock"'
Autor:
Lisa Hong, Dennis C. Braden, Yaoning Zhao, John J. Skoko, Fei Chang, Steven R. Woodcock, Crystall Uvalle, Allison Casey, Katherine Wood, Sonia R. Salvatore, Alparslan Asan, Trey Harkness, Adeola Fagunloye, Mortezaali Razzaghi, Adam Straub, Maria Spies, Daniel D. Brown, Adrian V. Lee, Francisco Schopfer, Bruce A. Freeman, Carola A. Neumann
Publikováno v:
Redox Biology, Vol 66, Iss , Pp 102856- (2023)
Nitro fatty acids (NO2-FAs) are endogenously generated lipid signaling mediators from metabolic and inflammatory reactions between conjugated diene fatty acids and nitric oxide or nitrite-derived reactive species. NO2-FAs undergo reversible Michael a
Externí odkaz:
https://doaj.org/article/74e2d4a459964b33908f0fc33cbe7493
Autor:
Marco Fazzari, Dario A. Vitturi, Steven R. Woodcock, Sonia R. Salvatore, Bruce A. Freeman, Francisco J. Schopfer
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 2, Pp 388-399 (2019)
Electrophilic nitro-fatty acids [NO2-FAs (fatty acid nitroalkenes)] showed beneficial signaling actions in preclinical studies and safety in phase 1 clinical trials. A detailed description of the pharmacokinetics (PK) of NO2-FAs is complicated by the
Externí odkaz:
https://doaj.org/article/b7f8eccab07f43aab87326995af65349
Autor:
Marco Fazzari, Steven R. Woodcock, Pascal Rowart, Karina Ricart, Jack R. Lancaster, Jr., Rakesh Patel, Dario A. Vitturi, Bruce A. Freeman, Francisco J. Schopfer
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101913- (2021)
Organic nitrate esters, long-recognized therapies for cardiovascular disorders, have not been detected biologically. We characterize in rat stomach unsaturated fatty acid nitration reactions that proceed by generation of nitro-nitrate intermediates (
Externí odkaz:
https://doaj.org/article/6ea57f2bc8e24cff85cf0065be293b6a
Autor:
Luis Villacorta, Lucia Minarrieta, Sonia R. Salvatore, Nicholas K. Khoo, Oren Rom, Zhen Gao, Rebecca C. Berman, Soma Jobbagy, Lihua Li, Steven R. Woodcock, Y. Eugene Chen, Bruce A. Freeman, Ana M. Ferreira, Francisco J. Schopfer, Dario A. Vitturi
Publikováno v:
Redox Biology, Vol 15, Iss C, Pp 522-531 (2018)
Conjugated linoleic acid (CLA) is a prime substrate for intra-gastric nitration giving rise to the formation of nitro-conjugated linoleic acid (NO2-CLA). Herein, NO2-CLA generation is demonstrated within the context of acute inflammatory responses bo
Externí odkaz:
https://doaj.org/article/5251ede04ce04c2aa2a7da02629b441d
Autor:
Marco Fazzari, NicholasK.H. Khoo, Steven R. Woodcock, Diane K. Jorkasky, Lihua Li, Francisco J. Schopfer, Bruce A. Freeman
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 2, Pp 375-385 (2017)
Electrophilic nitro-FAs (NO2-FAs) promote adaptive and anti-inflammatory cell signaling responses as a result of an electrophilic character that supports posttranslational protein modifications. A unique pharmacokinetic profile is expected for NO2-FA
Externí odkaz:
https://doaj.org/article/ac4e48e5c9d44e38bc99229f660c7782
Autor:
Jeffrey R. Koenitzer, Gustavo Bonacci, Steven R. Woodcock, Chen-Shan Chen, Nadiezhda Cantu-Medellin, Eric E. Kelley, Francisco J. Schopfer
Publikováno v:
Redox Biology, Vol 8, Iss C, Pp 1-10 (2016)
Nitro-fatty acids (NO2-FA) are metabolic and inflammatory-derived electrophiles that mediate pleiotropic signaling actions. It was hypothesized that NO2-FA would impact mitochondrial redox reactions to induce tissue-protective metabolic shifts in cel
Externí odkaz:
https://doaj.org/article/734c0fe8f5364d86a1484b0e58752578
Autor:
Mara Carreño, Maria F. Pires, Steven R. Woodcock, Tomasz Brzoska, Samit Ghosh, Sonia R. Salvatore, Fei Chang, Nicholas K. H. Khoo, Matthew Dunn, Nora Connors, Shuai Yuan, Adam C. Straub, Stacy G. Wendell, Gregory J. Kato, Bruce A. Freeman, Solomon F. Ofori-Acquah, Prithu Sundd, Francisco J. Schopfer, Dario A. Vitturi
Publikováno v:
Science advances. 8(26)
The up-regulation of kynurenine metabolism induces immunomodulatory responses via incompletely understood mechanisms. We report that increases in cellular and systemic kynurenine levels yield the electrophilic derivative kynurenine-carboxyketoalkene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc53acefca0e360f5b880e46faee37a0
https://pubmed.ncbi.nlm.nih.gov/35767602
https://pubmed.ncbi.nlm.nih.gov/35767602
Autor:
Sonia R. Salvatore, Dario A. Vitturi, Paul R.S. Baker, Gustavo Bonacci, Jeffrey R. Koenitzer, Steven R. Woodcock, Bruce A. Freeman, Francisco J. Schopfer
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 7, Pp 1998-2009 (2013)
The oxidation and nitration of unsaturated fatty acids transforms cell membrane and lipoprotein constituents into mediators that regulate signal transduction. The formation of 9-NO2-octadeca-9,11-dienoic acid and 12-NO2-octadeca-9,11-dienoic acid ste
Externí odkaz:
https://doaj.org/article/61ca34640d3b4f0b88b5342113ee5343
Autor:
Bentley M. Wingert, Chen-Shan Chen Woodcock, Yi Huang, Jeremy M. Stark, Daniel P. Normolle, Carlos J. Camacho, Alparslan Asan, Carola A. Neumann, Bruce A. Freeman, John J. Skoko, Steven R. Woodcock
Publikováno v:
Journal of Biological Chemistry. 294:397-404
Homologous recombination (HR)-directed DNA double-strand break (DSB) repair enables template-directed DNA repair to maintain genomic stability. RAD51 recombinase (RAD51) is a critical component of HR and facilitates DNA strand exchange in DSB repair.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdcce77e8392faffcd94a445fe25f16
https://doi.org/10.1074/jbc.ac118.005899
https://doi.org/10.1074/jbc.ac118.005899
Autor:
Francisco J. Schopfer, Bruce A. Freeman, Dario A. Vitturi, Pascal Rowart, Marco Fazzari, Jack J. Lancaster, Steven R. Woodcock
Publikováno v:
Free Radical Biology and Medicine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0695c9099b7cdca50f8be2285307bc7b
https://doi.org/10.1016/j.freeradbiomed.2020.01.180
https://doi.org/10.1016/j.freeradbiomed.2020.01.180