Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Steven R, Hustinx"'
1
Pancreatic Carcinogenesis
Autor: Jan-Bart M, Koorstra, Steven R, Hustinx, G Johan A, Offerhaus, Anirban, Maitra
Publikováno v: Pancreatology. 8:110-125
Pancreatic cancer is an almost universally lethal disease. Research over the last two decades has shown that pancreatic cancer is fundamentally a genetic disease, caused by inherited germline and acquired somatic mutations in cancer-associated genes.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe840e90b526a29dcc4958ba9b191bd
https://doi.org/10.1159/000123838
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2
Concordant loss of MTAP and p16/CDKN2A expression in pancreatic intraepithelial neoplasia: evidence of homozygous deletion in a noninvasive precursor lesion
Autor: Priscilla N. Brown, Scott E. Kern, Charles J. Yeo, Michael Goggins, Lorenzo M. Leoni, Anirban Maitra, Steven R. Hustinx, Ralph H. Hruban
Publikováno v: Modern Pathology. 18:959-963
The p16INK4A/CDKN2A (p16) gene on chromosome 9p21 is inactivated in >90% of invasive pancreatic cancers. In 40% of pancreatic cancers the p16 gene is inactivated by homozygous deletion, in 40% by an intragenic mutation coupled with loss of the second
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebb08a90068ca4b6ff92564317aa2d3
https://doi.org/10.1038/modpathol.3800377
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3
Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression
Autor: Scott E. Kern, Steven R. Hustinx, D. Sudhir, John L. Cameron, Akhilesh Pandey, Norihiro Sato, Christine A. Iacobuzio-Donahue, Charles J. Yeo, Michael Goggins, Anirban Maitra, S. T. Martin, Dengfeng Cao, Jan Mollenhauer, Ralph H. Hruban
Publikováno v: Cancer Biology & Therapy. 3:1254-1261
Serial analysis of gene expression (SAGE) is a powerful tool for the discovery of novel tumor markers. The publicly available online SAGE libraries of normal and neoplastic tissues (http://www.ncbi.nlm.nih.gov/SAGE/) have recently been expanded; in a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941a812d49f45574751ff29432d9d944
https://doi.org/10.4161/cbt.3.12.1238
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4
Identification of novel highly expressed genes in pancreatic ductal adenocarcinomas through a bioinformatics analysis of expressed sequence tags
Autor: Scott E. Kern, John L. Cameron, Ralph H. Hruban, Kathleen M. Murphy, Sean R. Martin, Steven R. Hustinx, P. Bala, Norihiro Sato, Guoping Sui, Akhilesh Pandey, Charles J. Yeo, Michael Goggins, Anirban Maitra, Dengfeng Cao
Publikováno v: Cancer Biology & Therapy. 3:1081-1089
In most microarray experiments, a significant fraction of the differentially expressed mRNAs identified correspond to expressed sequence tags (ESTs) and are generally discarded from further analyses. We used careful bioinformatics analyses to charact
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfbee9ea73c15aa6d114333593f860f
https://doi.org/10.4161/cbt.3.11.1175
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5
Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs
Autor: James R. Eshleman, Nijaguna B. Prasad, Noriyoshi Fukushima, Chanjuan Shi, Steven R. Hustinx, Ralph H. Hruban, Hiroyuki Matsubayashi, Carmelle D Rogers, Michael Goggins, Norihiro Sato, Marcia I. Canto
Publikováno v: Cancer biologytherapy. 5(10)
The gene expression profile of pancreatic cancer is significantly different from that of normal pancreas. Differences in gene expression are detectable using microarrays, but microarrays have traditionally been applied to pancreatic cancer tissue obt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e673d414c7ef90961937f46897f77b
https://pubmed.ncbi.nlm.nih.gov/17172808
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6
Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions
Autor: Keith D. Lillemoe, Michael A. Choti, Steven C. Cunningham, Min P. Kim, Charles J. Yeo, Richard E. Heitmiller, John L. Cameron, Raqeeb Haque, Sommer Hammoud, Elizabeth A. Montgomery, Richard D. Schulick, Anirban Maitra, Steven R. Hustinx, Raheela Ashfaq, Christine A. Iacobuzio-Donahue, Farin Kamangar
Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 15(2)
Approximately 23,000 new gastric cancer cases and 12,000 associated deaths occur annually in the United States. Intestinal metaplasia and gastric epithelial dysplasia are precursor lesions to gastric adenocarcinoma, but are not readily detectable cli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d39ed99cc2deb34ea3ec5549481991
https://pubmed.ncbi.nlm.nih.gov/16492916
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7
Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms
Autor: Michael Goggins, Norihiro Sato, S. T. Martin, Steven R. Hustinx, Toshiya Abe, Rubens Chang, Anirban Maitra, Surajit Dhara
Publikováno v: Cancer biologytherapy. 4(7)
Hedgehog pathway overactivity has been implicated in the development of a variety of human cancers. The Human Hedgehog interacting protein (HHIP), a negative regulator of hedgehog signaling, has been shown to be underexpressed in pancreatic cancers.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b8a9411e2b86e7a547306787202350
https://pubmed.ncbi.nlm.nih.gov/15970691
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