Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Steven Pirie-Shepherd"'
Autor:
Kenneth G. Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan, Ting-Ting Yamin, Jing Zhang, Riyez Karim, Joel Bard, Nicole Piche-Nicholas, Manoj Charati, Andreas Maderna, Judy Lucas, Jonathon Golas, Magali Guffroy, Steven Pirie-Shepherd, Marc Roy, Jessie Qian, Tania Franks, Wenyan Zhong, Christopher J. O’Donnell, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100279- (2021)
Summary: Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive. Here, we develop NOTCH3-targeted antibody drug conjugates (NOTCH3-ADCs) by bioconjug
Externí odkaz:
https://doaj.org/article/76d0c5083adc4e25955529b3fcfbbf6d
Autor:
Sripad Ram, Pamela Vizcarra, Pamela Whalen, Shibing Deng, C L Painter, Amy Jackson-Fisher, Steven Pirie-Shepherd, Xiaoling Xia, Eric L Powell
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0245638 (2021)
Immunohistochemistry (IHC) assays play a central role in evaluating biomarker expression in tissue sections for diagnostic and research applications. Manual scoring of IHC images, which is the current standard of practice, is known to have several sh
Externí odkaz:
https://doaj.org/article/b8922c40f36d48b9a4bdddcab8658a90
Autor:
Oliver Kisker, Shinya Onizuka, Christian M. Becker, Michael Fannon, Evelyn Flynn, Robert D'Amato, Bruce Zetter, Judah Folkman, Rahul Ray, Narasimha Swamy, Steven Pirie-Shepherd
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 5, Iss 1, Pp 32-40 (2003)
We have isolated a selectively deglycosylated form of vitamin D binding protein (DBP-maf) generated from systemically available DBP by a human pancreatic cancer cell line. DBP-maf is anti proliferative for endothelial cells and antiangiogenic in the
Externí odkaz:
https://doaj.org/article/5730b41e7d904f80980dd950bf8f2362
Autor:
Gallen Triana-Baltzer, Adam Pavlicek, Ariadne Goulart, Hanhua Huang, Steven Pirie-Shepherd, Nancy Levin
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80132 (2013)
The clinical efficacy of anti-angiogenic therapies has been difficult to predict, and biomarkers that can predict responsiveness are sorely needed in this era of personalized medicine. CVX-060 is an angiopoietin-2 (Ang2) targeting therapeutic, consis
Externí odkaz:
https://doaj.org/article/3655843bcd774251830c885c172e740a
Autor:
Kalvin J Gregory, Bing Zhao, Diane R Bielenberg, Sami Dridi, Jason Wu, Weihua Jiang, Bin Huang, Steven Pirie-Shepherd, Michael Fannon
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13428 (2010)
Vitamin D binding protein-macrophage activating factor (DBP-maf) is a potent inhibitor of tumor growth. Its activity, however, has been attributed to indirect mechanisms such as boosting the immune response by activating macrophages and inhibiting th
Externí odkaz:
https://doaj.org/article/ca82440e47d146e885c818cf76de5cfa
Autor:
Abhijit Bhat, Rodney Lappe, Gary Woodnutt, Curt Bradshaw, Nancy Levin, Steven Pirie-Shepherd, Venkata R. Doppalapudi, Joselyn Del Rosario, Lingna Li, Dingguo Liu, Janet Do, Jing-Yu Lai, Hanhua Huang
Purpose: Angiopoietin-1 (Ang1) plays a key role in maintaining stable vasculature, whereas in a tumor Ang2 antagonizes Ang1's function and promotes the initiation of the angiogenic switch. Specifically targeting Ang2 is a promising anticancer strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8888e2ec5a7529b9274cd867b85ba145
https://doi.org/10.1158/1078-0432.c.6520278.v1
https://doi.org/10.1158/1078-0432.c.6520278.v1
Autor:
Anthony W. Tolcher, Steven Pirie-Shepherd, Robert Wesolowski, Brenda Gibson, Lee S. Rosen, Steven Y. Hua, Kai-Hsin Liao, Raffaele Baffa
Publikováno v:
Investigational New Drugs. 38:120-130
Background PF-06650808 is a novel anti-Notch3 antibody–drug conjugate (ADC) able to deliver an auristatin-based cytotoxic payload to target cells. In this first-in-human, dose-finding, phase I study (NCT02129205), we investigated safety, pharmacoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a683116c97ca88234178e12efdc152ad
https://doi.org/10.1007/s10637-019-00754-y
https://doi.org/10.1007/s10637-019-00754-y
Autor:
Erika Hamilton, Theresa L. Werner, Ignacio Garrido-Laguna, Christopher J. Zopf, Amy Weise, Ian E. Krop, Maysa M. Abu-Khalaf, Mani Lakshminarayanan, Steven Pirie-Shepherd, David S. Hong, Jaymes S. Holland, Raffaele Baffa, Fadi Braiteh, Howard A. Burris
Publikováno v:
International Journal of Cancer. 145:1798-1808
PF-06647263, a novel antibody-drug conjugate consisting of an anti-EFNA4 antibody linked to a calicheamicin payload, has shown potent antitumor activity in human xenograft tumor models, including triple-negative breast cancer (TNBC). In the dose-esca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32d64a23ee601087b700c413f490d19a
https://doi.org/10.1002/ijc.32154
https://doi.org/10.1002/ijc.32154
Autor:
Pamela Vizcarra, Eric L. Powell, Cory L. Painter, Pamela Whalen, Amy Jackson-Fisher, Shibing Deng, Steven Pirie-Shepherd, Sripad Ram, Xiaoling Xia
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0245638 (2021)
PLoS ONE, Vol 16, Iss 9, p e0245638 (2021)
Immunohistochemistry (IHC) assays play a central role in evaluating biomarker expression in tissue sections for diagnostic and research applications. Manual scoring of IHC images, which is the current standard of practice, is known to have several sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0737889c298e5bf19f891ae9dbe279df
https://pubmed.ncbi.nlm.nih.gov/34570796
https://pubmed.ncbi.nlm.nih.gov/34570796
Autor:
Magali Guffroy, Steven Pirie-Shepherd, Puja Sapra, Judy Lucas, Jonathon Golas, Kenneth G. Geles, Joel Bard, Nicole Piche-Nicholas, Riyez Karim, Hans-Peter Gerber, Latha Sridharan, Lioudmila Tchistiakova, Andreas Giannakou, Jing Zhang, Manoj Charati, Tania Franks, Wenyan Zhong, Ting-Ting Yamin, Yijie Gao, Jessie Qian, Marc D. Roy, Andreas Maderna, Christopher J. O’Donnell
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100279-(2021)
Cell Reports Medicine
Cell Reports Medicine
Summary Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive. Here, we develop NOTCH3-targeted antibody drug conjugates (NOTCH3-ADCs) by bioconjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0591a6f1173fde81b769ca95def20526
https://doi.org/10.1016/j.xcrm.2021.100279
https://doi.org/10.1016/j.xcrm.2021.100279