Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons

Autor: Carlos G. Sanchez, Christopher M. Acker, Audrey Gray, Malini Varadarajan, Cheng Song, Nadire R. Cochran, Steven Paula, Alicia Lindeman, Shaojian An, Gregory McAllister, John Alford, John Reece-Hoyes, Carsten Russ, Lucas Craig, Ketthsy Capre, Christian Doherty, Gregory R. Hoffman, Sarah J. Luchansky, Manuela Polydoro, Ricardo Dolmetsch, Fiona Elwood

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)

Using an unbiased genome-wide CRISPR screen approach, Sanchez et al. identified modulators of endogenous tau protein. This study suggests that chromatin modifiers, neddylation, ubiquitination, and the mTOR pathways regulate overall levels of tau prot

Externí odkaz: https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2

Data from Lenalidomide Enhances Immune Checkpoint Blockade-Induced Immune Response in Multiple Myeloma

Autor: Kenneth C. Anderson, Paul G. Richardson, David M. Dorfman, Nikhil C. Munshi, Herve Avet-Loiseau, Stephane Minvielle, Florence Magrangeas, Noopur Raje, Jacob P. Laubach, Yu-Tzu Tai, Teru Hideshima, Takeshi Harada, Shohei Kikuchi, Rikio Suzuki, Hiroto Ohguchi, Ahaana Singh, Randie E. White, Julie E. Anderson, Giada Bianchi, Steven Paula, Kristen B. Cowens, Mehmet K. Samur, Güllü Görgün

Purpose: PD-1/PD-L1 signaling promotes tumor growth while inhibiting effector cell–mediated antitumor immune responses. Here, we assessed the impact of single and dual blockade of PD-1/PD-L1, alone or in combination with lenalidomide, on accessory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82300ab2156b67b18340ddd722c8880f
https://doi.org/10.1158/1078-0432.c.6524619

Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons

Autor: Fiona Elwood, John Alford, Carsten Russ, Christopher Acker, Audrey Gray, John S. Reece-Hoyes, Carlos G Sanchez, Sarah J. Luchansky, Christian Doherty, Lucas Craig, Gregory McAllister, Steven Paula, Ricardo E. Dolmetsch, Shaojian An, Cheng Song, Alicia Lindeman, Malini Varadarajan, Nadire Cochran, Manuela Polydoro, Ketthsy Capre, Gregory R. Hoffman

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology

Aggregates of hyperphosphorylated tau protein are a pathological hallmark of more than 20 distinct neurodegenerative diseases, including Alzheimer’s disease, progressive supranuclear palsy, and frontotemporal dementia. While the exact mechanism of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a06bbe1da74cbde2af5f7fb1d3fc80e
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2

Genome-Scale CRISPR Screening Identifies Novel Human Pluripotent Gene Networks

Autor: Gregory R. Hoffman, Kathleen A. Worringer, Ranjit Randhawa, Sravya Kommineni, Robert J. Ihry, Gregory McAllister, Marie Sondey, Steven Paula, Ricardo E. Dolmetsch, Zinger Yang, Ajamete Kaykas, Elizabeth Frias, Daniel J. Ho, Joe Raymond, Bob Altshuler, Max R. Salick, Carsten Russ, John S. Reece-Hoyes

Publikováno v: SSRN Electronic Journal.

Human pluripotent stem cells (hPSCs) generate a wide variety of disease-relevant cells that can be used to improve the translation of preclinical research. Despite the potential of hPSCs, their use for genetic screening has been limited because of te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c345a1bdb5c383f6a79f625d6ac07ed
https://doi.org/10.2139/ssrn.3189387

Lenalidomide Enhances Immune Checkpoint Blockade-Induced Immune Response in Multiple Myeloma

Autor: Mehmet Kemal Samur, Hervé Avet-Loiseau, Kristen Cowens, Randie E White, Gullu Gorgun, Florence Magrangeas, Giada Bianchi, David M. Dorfman, Jacob P. Laubach, Rikio Suzuki, Noopur Raje, Ahaana Singh, Nikhil C. Munshi, Stephane Minvielle, Steven Paula, Teru Hideshima, Shohei Kikuchi, Julie E. Anderson, Yu-Tzu Tai, Paul G. Richardson, Kenneth C. Anderson, Takeshi Harada, Hiroto Ohguchi

Publikováno v: Clinical Cancer Research
Clinical Cancer Research, 2015, 21, pp.4607-4625. ⟨10.1158/1078-0432.CCR-15-0200⟩
Clinical Cancer Research, American Association for Cancer Research, 2015, 21, pp.4607-4625. ⟨10.1158/1078-0432.CCR-15-0200⟩

Purpose: PD-1/PD-L1 signaling promotes tumor growth while inhibiting effector cell–mediated antitumor immune responses. Here, we assessed the impact of single and dual blockade of PD-1/PD-L1, alone or in combination with lenalidomide, on accessory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5373debfd8ef9fac6d6b54024a2ef4
https://www.hal.inserm.fr/inserm-02536335/file/Magrangeas2015Eq11.pdf