Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Steven Paraskevas"'
Autor:
Ahmed Fouda, Mohamed Taoubane Maallah, Araz Kouyoumdjian, Sarita Negi, Steven Paraskevas, Jean Tchervenkov
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Chronic antibody mediated rejection (AMR) is the major cause of solid organ graft rejection. Th17 contributes to AMR through the secretion of IL17A, IL21 and IL22. These cytokines promote neutrophilic infiltration, B cell proliferation and d
Externí odkaz:
https://doaj.org/article/d856c436a126483689babcb4ff2d3ee0
Publikováno v:
Frontiers in Transplantation, Vol 3 (2024)
IntroductionSensitization to donor human leukocyte antigen (HLA) molecules prior to transplantation is a significant risk factor for delayed access to transplantation and to long-term outcomes. Memory T cells and their cytokines play a pivotal role i
Externí odkaz:
https://doaj.org/article/7babce58abef47af8c0054d145c0edbc
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Tumor necrosis factor receptor 2 (TNFR2) has been shown to play a crucial role in CD4+ T regulatory cells (CD4+Tregs) expansion and suppressive function. Increasing evidence has also demonstrated its role in a variety of immune regulatory cell subtyp
Externí odkaz:
https://doaj.org/article/7050f161972c42659ed66d11bcff015e
Autor:
Alissa K. Rutman, Sarita Negi, Nasim Saberi, Kashif Khan, Jean Tchervenkov, Steven Paraskevas
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Delayed graft function (DGF) in kidney transplantation is associated with ischemic injury and carries long term functional and immunological risks. Extracellular vesicles (EV) released from allografts may signal a degree of ischemic stress, and are t
Externí odkaz:
https://doaj.org/article/7178ba79512447cc8608129f23722a27
Autor:
Ivan Yanev, Michael Gagnon, Matthew P. Cheng, Steven Paraskevas, Deepali Kumar, Alice Dragomir, Ruth Sapir-Pichhadze
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 8 (2021)
Background: The coronavirus disease 2019 (COVID-19) pandemic impacted transplant programs across Canada. Objective: We evaluated the implications of delays in transplantation among Canadian end-stage kidney disease (ESKD) patients to allow pretranspl
Externí odkaz:
https://doaj.org/article/300ec7b6223a4187a37b01cf1f654d19
Autor:
Stephanie A. Fernandez, Lisa Danielczak, Gabrielle Gauvin-Rossignol, Craig Hasilo, André Bégin-Drolet, Jean Ruel, Steven Paraskevas, Richard L. Leask, Corinne A. Hoesli
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Transplantation of hydrogel-encapsulated pancreatic islets is a promising long-term treatment for type 1 diabetes that restores blood glucose regulation while providing graft immunoprotection. Most human-scale islet encapsulation devices that rely so
Externí odkaz:
https://doaj.org/article/2e4a1cd12a2d48e39030a3fa25bda5df
Autor:
Craig P. Hasilo, Sarita Negi, Isabelle Allaeys, Nathalie Cloutier, Alissa K. Rutman, Marco Gasparrini, Éric Bonneil, Pierre Thibault, Éric Boilard, Steven Paraskevas
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Beta-cell (β-cell) injury is the hallmark of autoimmune diabetes. However, the mechanisms by which autoreactive responses are generated in susceptible individuals are not well understood. Extracellular vesicles (EV) are produced by mammalia
Externí odkaz:
https://doaj.org/article/5cc65e26c9a04fa5a780db8b66742e77
Autor:
Thomas Lescot, Constantine J Karvellas, Prosanto Chaudhury, Jean Tchervenkov, Steven Paraskevas, Jeffrey Barkun, Peter Metrakos, Peter Goldberg, Sheldon Magder
Publikováno v:
Canadian Journal of Gastroenterology, Vol 27, Iss 4, Pp 207-212 (2013)
BACKGROUND: Delirium is common in intensive care unit patients and is associated with worse outcome.
Externí odkaz:
https://doaj.org/article/e3cf15bd0df74d4597559cc74bb0f624
Autor:
Sarita Negi, Soon Hyang Park, Arif Jetha, Reid Aikin, Michel Tremblay, Steven Paraskevas M.D., Ph.D.
Publikováno v:
Cell Transplantation, Vol 21 (2012)
A key limitation to the success of islet transplantation is islet cell exhaustion and cell death during islet isolation and following transplantation. Endoplasmic reticulum (ER) stress has been identified as an important mechanism in the development
Externí odkaz:
https://doaj.org/article/df060e9988574d4c8c84a31687af60f9
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30415 (2012)
The stresses encountered during islet isolation and culture may have deleterious effects on beta-cell physiology. However, the biological response of human islet cells to isolation remains poorly characterized. A better understanding of the network o
Externí odkaz:
https://doaj.org/article/bd008c1e568f48e0836fd64b1709aedf