Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Steven P. Tanis"'
Autor:
Jinmei Li, Sandeep Kumar, Kirill Miachin, Nicholas L. Bean, Ornella Halawi, Scott Lee, JiWoong Park, Tanya H. Pierre, Jin-Hui Hor, Shi-Yan Ng, Kelvin J. Wallace, Niklas Rindtorff, Timothy M. Miller, Michael L. Niehoff, Susan A. Farr, Rolf F. Kletzien, Jerry Colca, Steven P. Tanis, Yana Chen, Kristine Griffett, Kyle S. McCommis, Brian N. Finck, Tim R. Peterson
The geroscience hypothesis states that a therapy that prevents the underlying aging process should prevent multiple aging related diseases. The mTOR (mechanistic target of rapamycin)/insulin and NAD+ (nicotinamide adenine dinucleotide) pathways are t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1405679920f87a4b520c9c1e6b6b6358
https://doi.org/10.1101/2023.01.16.523975
https://doi.org/10.1101/2023.01.16.523975
Autor:
Jin Zhuang, Priya Karmali, Padmanabh Chivukula, Ian Edmonds, Kumar Rajappan, Steven P. Tanis, Mingxing Xin, Scott C. Roberts, Manman Zheng
Publikováno v:
Organic Process Research & Development. 25:1383-1390
Autor:
Yihua, Pei, Yanjie, Bao, Cristiano, Sacchetti, Juthamart, Brady, Kyra, Gillard, Hailong, Yu, Scott, Roberts, Kumar, Rajappan, Steven P, Tanis, Carlos G, Perez-Garcia, Padmanabh, Chivukula, Priya P, Karmali
Publikováno v:
Chemistry and Physics of Lipids. 243:105178
Lipid nanoparticles (LNPs) mediated mRNA delivery has gained prominence due to the success of mRNA vaccines against Covid-19, without which it would not have been possible. However, there is little clinical validation of this technology for other mRN
Autor:
Priya Karmali, Pattraranee Limphong, Hailong Yu, Kiyoshi Tachikawa, Padmanabh Chivukula, Rajesh Mukthavaram, Angel I-Jou Leu, Marciano Sablad, Joseph E. Payne, Steven P. Tanis, Michelle Nguyen, Scott C. Roberts, Kumar Rajappan, Amit Sagi
Publikováno v:
Journal of medicinal chemistry. 63(21)
Ionizable cationic lipids are critical components involved in nanoparticle formulations, which are utilized in delivery platforms for RNA therapeutics. While general criteria regarding lipophilicity and measured pKa in formulation are understood to h
Autor:
William G. McDonald, Scott D. Larsen, Rolf F. Kletzien, James B. Zeller, Steven P. Tanis, Wade J. Adams, Gerald D. Artman, Jerry R. Colca, Timothy Parker, Pil H. Lee, Robert C. Gadwood
Publikováno v:
Bioorganicmedicinal chemistry. 26(22)
Autor:
Gerald D. Artman, James R. Zeller, Timothy Parker, Robert C. Gadwood, Scott D. Larsen, Steven P. Tanis, Jerry R. Colca
Publikováno v:
Tetrahedron Letters. 60:150931
Ketones 2 (MSDC-0160) and 3 (MSDC-0602) had been selected for clinical development, however their initial syntheses were considered suboptimal for application deep into clinical trials. Difficulties ranging from the nature of the starting material, a
Autor:
Tran Khanh Tuan, Qiyue Hu, Zhang Junhu, Scott L. Butler, Atsuo Kuki, Qinghai Peng, Erik Jon Flahive, Graham L. Smith, Huichun Zhu, Deepak Dalvie, Plewe Michael Bruno, Jim Solowiej, Dorothy Delisle, Ted William Johnson, Wen Liu, Steven P. Tanis, Klaus Ruprecht Dress, Jon E. Kuehler, Guy A. McClellan, Xiaoming Yu, Hai Wang, Paul F. Richardson
Publikováno v:
Journal of Medicinal Chemistry. 54:3393-3417
HIV-1 integrase (IN) is one of three enzymes encoded by the HIV genome and is essential for viral replication, and HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Recently, we reported the synthesis of orally bioavailable a
Autor:
Qinghai Peng, Tran Khanh Tuan, Atsuo Kuki, Steven P. Tanis, Zhang Junhu, Deepak Dalvie, Yang Anle, Xiaoming Yu, Jim Solowiej, Ted William Johnson, Hai Wang, Wen Liu, Plewe Michael Bruno, Buwen Huang, Graham L. Smith, Jon E. Kuehler, Klaus Ruprecht Dress, Chunfeng Yin, Qiyue Hu, Dorothy Delisle, Huichun Zhu, Scott L. Butler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7429-7434
HIV-1 integrase is one of three enzymes encoded by the HIV genome and is essential for viral replication, and HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Recently, we reported the discovery of azaindole hydroxamic acids
Autor:
Chunrong Ma, Alan W. Grubbs, Jean Joo Matthews, Steven P. Tanis, Sajiv Krishnan Nair, Erik Jon Flahive, Jim van Wiltenburg, Neal W. Sach, Wolter Ten Hoeve, Elena Z. Dovalsantos, Matt Renner, Cripps Stephan James, Han Koster
Publikováno v:
Tetrahedron Letters. 51:1451-1454
A novel and efficient asymmetric route to CP-734432, a lactam analog of PGE2, that shows selective agonism against the EP4 receptor subtype, is reported herein. The key steps include a Heck coupling to introduce the aryl ring at C-16 and a highly dia
Autor:
Qinghai Peng, Nowlin Dawn Marie, Hieu Lam, Ted William Johnson, Yang Anle, Wen Liu, Atsuo Kuki, Steven P. Tanis, Jon E. Kuehler, Zhang Junhu, Hai Wang, Plewe Michael Bruno, Scott L. Butler, Tran Khanh Tuan, Qiyue Hu, Sadayappan V. Rahavendran, Klaus Ruprecht Dress
Publikováno v:
Journal of Medicinal Chemistry. 52:7211-7219
HIV-1 integrase (IN) is one of three enzymes encoded by the HIV genome and is essential for viral replication. Recently, HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Herein, we report the discovery of azaindole carboxyli