Výsledky vyhledávání - "Steven P. Luckman"

Akademický článek

Matrix Metalloproteinase-3 in Myasthenia Gravis Compared to Other Neurological Disorders and Healthy Controls

Autor: Steven P. Luckman, Nils Erik Gilhus, Fredrik Romi

Publikováno v: Autoimmune Diseases, Vol 2011 (2011)

MMP-3 is capable of degrading a variety of proteins, including agrin, which plays a critical role in neuromuscular signaling by controlling acetylcholine receptor clustering. High MMP-3 levels in a proportion of myasthenia gravis (MG) patients have b

Externí odkaz: https://doaj.org/article/ab47cfe4906545d595c4ae236d69dcac

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The pharmacology of bisphosphonates and new insights into their mechanisms of action

Autor: C M Shipman, Steven P. Luckman, H L Benford, Roslin Russell, Michael J. Rogers, Peter I. Croucher, Herbert Fleisch, Julie C. Frith, Fraser P. Coxon

Publikováno v: ResearcherID
Scopus-Elsevier

Bisphosphonates are chemically stable analogs of inorganic pyrophosphate, which are resistant to breakdown by enzymatic hydrolysis. The biological effects of bisphosphonates on calcium metabolism were originally ascribed to their physico-chemical eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fccf1519b2655a9718bb9d7245d9bd
https://ora.ox.ac.uk/objects/uuid:be5ffeb7-ced3-440e-bdfe-5b5f9a268ff8

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Matrix Metalloproteinases in Myasthenia Gravis

Autor: Gordon T. Plant, Geir Helgeland, Steven P. Luckman, Axel Petzold, Nils Erik Gilhus, Fredrik Romi

Publikováno v: European Neurology, 65(1), 53-58. S. Karger AG
Helgeland, G, Petzold, A F S, Luckman, S P, Gilhus, N E, Plant, G T & Romi, F R 2011, ' Matrix Metalloproteinases in Myasthenia Gravis ', European Neurology, vol. 65, no. 1, pp. 53-58 . https://doi.org/10.1159/000322737

Introduction: Myasthenia gravis (MG) is an autoimmune disease with weakness in striated musculature due to anti-acetylcholine receptor (AChR) antibodies or muscle specific kinase at the neuromuscular junction. A subgroup of patients has periocular sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afcca9c69fee25654cd7d726bf927027
https://hdl.handle.net/1871/37234

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Serum matrix metalloproteinase-3 levels are elevated in myasthenia gravis

Autor: Steven P. Luckman, Fredrik Romi, Nils Erik Gilhus

Publikováno v: Journal of Neuroimmunology. 195:96-99

MMP-3 is capable of degrading a variety of proteins, including agrin, which plays a critical role in neuromuscular signalling by controlling acetylcholine receptor clustering. The degradation of agrin by MMP-3 may disrupt the neuromuscular junction l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348eb0172862b8d6f9670343097df7f1
https://doi.org/10.1016/j.jneuroim.2007.10.018

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Partial characterization of cell-type X collagen interactions

Autor: Elaine Rees, Steven P Luckman, Alvin P. L. Kwan

Publikováno v: Biochemical Journal. 372:485-493

Type X collagen is a short-chain non-fibrillar collagen that is deposited exclusively at sites of new bone formation. Although this collagen has been implicated in chondrocyte hypertrophy and endochondral ossification, its precise function remains un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ef167a1488033b8e864ae557541009
https://doi.org/10.1042/bj20021572

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Molecular mechanisms of action of bisphosphonates

Autor: Steven P. Luckman, Jukka Mönkkönen, K. M. Chilton, Michael J. Rogers, H L Benford, Roslin Russell, F P Coxon, Seppo Auriola, Julie C. Frith

Publikováno v: Bone. 24:73S-79S

BPs can be grouped into two general classes according to their chemical structure and the molecular mechanism by which they inhibit osteoclast-mediated bone resorption. The simple BPs can be metabolically incorporated into non-hydrolysable analogues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc204f0e7b20c8d6fda98fe86729639b
https://doi.org/10.1016/s8756-3282(99)00070-8

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Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

Autor: P. J. Masarachia, Steven P. Luckman, D. E. Hughes, Roslin Russell, A. A. Reszka, Gideon A. Rodan, J. M. Halasy, Michael J. Rogers, John E. Fisher, Gregg Wesolowski

Publikováno v: Proceedings of the National Academy of Sciences. 96:133-138

Nitrogen-containing bisphosphonates were shown to cause macrophage apoptosis by inhibiting enzymes in the biosynthetic pathway leading from mevalonate to cholesterol. This study suggests that, in osteoclasts, geranylgeranyl diphosphate, the substrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a796e883d896cd436568db266dcfaf81
https://doi.org/10.1073/pnas.96.1.133

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Heterocycle-Containing Bisphosphonates Cause Apoptosis and Inhibit Bone Resorption by Preventing Protein Prenylation: Evidence from Structure-Activity Relationships in J774 Macrophages

Autor: Frank H. Ebetino, Michael J. Rogers, Steven P. Luckman, F P Coxon, R. Graham G. Russell

Publikováno v: Journal of Bone and Mineral Research. 13:1668-1678

Recent evidence suggests that bisphosphonates (BPs) may inhibit bone resorption by mechanisms that lead to osteoclast apoptosis. We have previously shown that BPs also reduce cell viability and induce apoptosis in the macrophage-like cell line J774.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b9017264b82fe4375f976bcdc5bd1e
https://doi.org/10.1359/jbmr.1998.13.11.1668

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Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras

Autor: R. Graham G. Russell, D. E. Hughes, Steven P. Luckman, Michael J. Rogers, F P Coxon

Publikováno v: Journal of Bone and Mineral Research. 13:581-589

Bisphosphonates are currently the most important class of antiresorptive drugs used for the treatment of metabolic bone diseases. Although the molecular targets of bisphosphonates have not been identified, these compounds inhibit bone resorption by m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d6fb266f6a5c96734fc3a49f190387
https://doi.org/10.1359/jbmr.1998.13.4.581

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