Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Steven P. Govek"'
Autor:
James D Joseph, Beatrice Darimont, Wei Zhou, Alfonso Arrazate, Amy Young, Ellen Ingalla, Kimberly Walter, Robert A Blake, Jim Nonomiya, Zhengyu Guan, Lorna Kategaya, Steven P Govek, Andiliy G Lai, Mehmet Kahraman, Dan Brigham, John Sensintaffar, Nhin Lu, Gang Shao, Jing Qian, Kate Grillot, Michael Moon, Rene Prudente, Eric Bischoff, Kyoung-Jin Lee, Celine Bonnefous, Karensa L Douglas, Jackaline D Julien, Johnny Y Nagasawa, Anna Aparicio, Josh Kaufman, Benjamin Haley, Jennifer M Giltnane, Ingrid E Wertz, Mark R Lackner, Michelle A Nannini, Deepak Sampath, Luis Schwarz, Henry Charles Manning, Mohammed Noor Tantawy, Carlos L Arteaga, Richard A Heyman, Peter J Rix, Lori Friedman, Nicholas D Smith, Ciara Metcalfe, Jeffrey H Hager
Publikováno v:
eLife, Vol 8 (2019)
Externí odkaz:
https://doaj.org/article/d1935c5b03e6433ea06acf491e7dc6f2
Autor:
James D Joseph, Beatrice Darimont, Wei Zhou, Alfonso Arrazate, Amy Young, Ellen Ingalla, Kimberly Walter, Robert A Blake, Jim Nonomiya, Zhengyu Guan, Lorna Kategaya, Steven P Govek, Andiliy G Lai, Mehmet Kahraman, Dan Brigham, John Sensintaffar, Nhin Lu, Gang Shao, Jing Qian, Kate Grillot, Michael Moon, Rene Prudente, Eric Bischoff, Kyoung-Jin Lee, Celine Bonnefous, Karensa L Douglas, Jackaline D Julien, Johnny Y Nagasawa, Anna Aparicio, Josh Kaufman, Benjamin Haley, Jennifer M Giltnane, Ingrid E Wertz, Mark R Lackner, Michelle A Nannini, Deepak Sampath, Luis Schwarz, Henry Charles Manning, Mohammed Noor Tantawy, Carlos L Arteaga, Richard A Heyman, Peter J Rix, Lori Friedman, Nicholas D Smith, Ciara Metcalfe, Jeffrey H Hager
Publikováno v:
eLife, Vol 5 (2016)
ER-targeted therapeutics provide valuable treatment options for patients with ER+ breast cancer, however, current relapse and mortality rates emphasize the need for improved therapeutic strategies. The recent discovery of prevalent ESR1 mutations in
Externí odkaz:
https://doaj.org/article/e0d8a246d19143f9bd877f0b6caa0659
Autor:
Karensa L. Douglas, Kyoung-Jin Lee, Johnny Y. Nagasawa, Anna Aparicio, Nhin Lu, Andiliy G. Lai, Joshua A. Kaufman, Mehmet Kahraman, Celine Bonnefous, John Sensintaffar, Jeffrey H. Hager, James Joseph, Steven P. Govek, Peter J. Rix, Michael J. Moon, Rene Prudente, Katherine L. Grillot, Julien Jackaline D, Beatrice Darimont, Nicholas D. Smith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:367-372
Potent estrogen receptor ligands typically contain a phenolic hydrogen-bond donor. The indazole of the selective estrogen receptor degrader (SERD) ARN-810 is believed to mimic this. Disclosed herein is the discovery of ARN-810 analogs which lack this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652ad125c719f124722ac974d5c62830
https://doi.org/10.1016/j.bmcl.2018.12.042
https://doi.org/10.1016/j.bmcl.2018.12.042
Autor:
Celine Bonnefous, Steven P. Govek, James Joseph, Nicholas D. Smith, Kyoung-Jin Lee, John Sensintaffar, Jeffrey H. Hager, Karensa L. Douglas, Andiliy G. Lai, Daniel Brigham, Richard A. Heyman, Johnny Y. Nagasawa, Mehmet Kahraman, Nhin Liu, Jing Qian, Anna Aparicio, Josh Kaufman, Gang Shao, Rene Prudente, Peter J. Rix, Beatrice Darimont
Publikováno v:
ACS Medicinal Chemistry Letters. 10:50-55
[Image: see text] The further optimization of ER-α degradation efficacy of a series of ER modulators by refining side-chain substitution led to efficacious selective estrogen receptor degraders (SERDs). A fluoromethyl azetidine group was found to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdff9ac5315f3b9ec912ea88414ce7d
https://doi.org/10.1021/acsmedchemlett.8b00414
https://doi.org/10.1021/acsmedchemlett.8b00414
Autor:
Daniel Brigham, Anna Aparicio, Karensa L. Douglas, Jeffrey H. Hager, Jing Qian, James Joseph, Celine Bonnefous, Gang Shao, Kate Maheu, Steven P. Govek, Richard A. Heyman, Nhin Lu, Nicholas D. Smith, Peter J. Rix, Andiliy G. Lai, Mehmet Kahraman, Johnny Y. Nagasawa, Kyoung-Jin Lee, Beatrice Darimont, John Sensintaffar, Josh Kaufman, Rene Prudente
Publikováno v:
Journal of Medicinal Chemistry. 61:7917-7928
About 75% of breast cancers are estrogen receptor alpha (ER-α) positive, and women typically initially respond well to antihormonal therapies such as tamoxifen and aromatase inhibitors, but resistance often emerges. Fulvestrant is a steroid-based, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f72964be7607fc34e509ba9d0d22b2
https://doi.org/10.1021/acs.jmedchem.8b00921
https://doi.org/10.1021/acs.jmedchem.8b00921
Autor:
Kyoung Jin Lee, Alfonso Arrazate, Carlos L. Arteaga, Robert A. Blake, Peter J. Rix, Nhin Lu, Steven P. Govek, Mohammed N. Tantawy, Jeffrey H. Hager, Eric D. Bischoff, Jim Nonomiya, Kimberly Walter, Andiliy G. Lai, Kate Grillot, Richard A. Heyman, Ellen Ingalla, Rene Prudente, Lorna Kategaya, Luis J. Schwarz, Gang Shao, Wei Zhou, Benjamin Haley, Ciara Metcalfe, Deepak Sampath, Jennifer M. Giltnane, Dan Brigham, James Joseph, Josh Kaufman, Mark R. Lackner, Beatrice Darimont, Michelle Nannini, Amy E. Young, John Sensintaffar, Karensa L. Douglas, Julien Jackaline D, Zhengyu Guan, Ingrid E. Wertz, Michael Moon, Anna Aparicio, Nicholas D. Smith, Celine Bonnefous, Johnny Y. Nagasawa, Henry C. Manning, Mehmet Kahraman, Jing Qian, Lori Friedman
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
ER-targeted therapeutics provide valuable treatment options for patients with ER+ breast cancer, however, current relapse and mortality rates emphasize the need for improved therapeutic strategies. The recent discovery of prevalent ESR1 mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423a338e3a39a15221938996be372244
http://europepmc.org/articles/PMC6322858
http://europepmc.org/articles/PMC6322858
Autor:
Gang Shao, Dan Brigham, Henry C. Manning, Mohammed N. Tantawy, Michael Moon, Zhengyu Guan, Amy Young, Ingrid E. Wertz, Anna Aparicio, Carlos L. Arteaga, Lori Friedman, Kyoung Jin Lee, Luis J. Schwarz, Jennifer M. Giltnane, Mehmet Kahraman, Robert A. Blake, Wei Zhou, Alfonso Arrazate, Eric D. Bischoff, Benjamin Haley, Josh Kaufman, Jim Nonomiya, Deepak Sampath, Peter J. Rix, Kate Grillot, Lorna Kategaya, Ellen Ingalla, John Sensintaffar, Ciara Metcalfe, Celine Bonnefous, Johnny Y. Nagasawa, Richard A. Heyman, Beatrice Darimont, Michelle Nannini, Steven P. Govek, Jeffrey H. Hager, Kimberly Walter, Nhin Lu, Rene Prudente, Mark R. Lackner, Karensa L. Douglas, Julien Jackaline D, Nicholas D. Smith, Andiliy G. Lai, Jing Qian, James Joseph
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
ER-targeted therapeutics provide valuable treatment options for patients with ER+ breast cancer, however, current relapse and mortality rates emphasize the need for improved therapeutic strategies. The recent discovery of prevalent ESR1 mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb077868268cfcb3a3715b2d9ce59379
https://doi.org/10.7554/elife.15828
https://doi.org/10.7554/elife.15828
Autor:
James D Joseph, Beatrice Darimont, Wei Zhou, Alfonso Arrazate, Amy Young, Ellen Ingalla, Kimberly Walter, Robert A Blake, Jim Nonomiya, Zhengyu Guan, Lorna Kategaya, Steven P Govek, Andiliy G Lai, Mehmet Kahraman, Dan Brigham, John Sensintaffar, Nhin Lu, Gang Shao, Jing Qian, Kate Grillot, Michael Moon, Rene Prudente, Eric Bischoff, Kyoung-Jin Lee, Celine Bonnefous, Karensa L Douglas, Jackaline D Julien, Johnny Y Nagasawa, Anna Aparicio, Josh Kaufman, Benjamin Haley, Jennifer M Giltnane, Ingrid E Wertz, Mark R Lackner, Michelle A Nannini, Deepak Sampath, Luis Schwarz, Henry Charles Manning, Mohammed Noor Tantawy, Carlos L Arteaga, Richard A Heyman, Peter J Rix, Lori Friedman, Nicholas D Smith, Ciara Metcalfe, Jeffrey H Hager
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efacfb3ed19a9aba3fed3faccefbccfc
https://doi.org/10.7554/elife.15828.026
https://doi.org/10.7554/elife.15828.026
Autor:
Lori Friedman, Josh Kaufman, Wei Zhou, Rene Prudente, Jane Guan, Gang Shao, Karensa L. Douglas, Sharada Labadie, Edna F. Choo, Tracy Kleinheinz, Nhin Lu, Anna Aparicio, Steven J. Hartman, Xiaojing Wang, Steven P. Govek, Peter J. Rix, Robert A. Blake, Maia Vinogradova, John Sensintaffar, Anneleen Daemen, Celine Bonnefous, Nicholas D. Smith, Beatrice Darimont, Michelle Nannini, Richard A. Heyman, Vidhi Mody, Ellen Ingalla, Andiliy G. Lai, Johnny Y. Nagasawa, Ciara Metcalfe, Jeffrey H. Hager, James Joseph, Jing Qian, Amy E. Young, Jae H. Chang, Daniel Brigham, Mehmet Kahraman, James R. Kiefer, Kyoung-Jin Lee, Deepak Sampath, Jun Liang
Publikováno v:
Cancer Research. 78:1648-1648
Breast cancer is the most frequently diagnosed cancer among women and remains the second leading cause of cancer death in women. An estimated 70% of all breast cancers express estrogen receptor alpha (ERα); and endocrine therapies have validated ER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7df1f096b9152fb290fdb99031050567
https://doi.org/10.1158/1538-7445.am2018-1648
https://doi.org/10.1158/1538-7445.am2018-1648
Autor:
Steven P. Govek, Larry E. Overman
Publikováno v:
Tetrahedron. 63:8499-8513
The first total synthesis of the structurally novel cyclotryptophan alkaloid asperazine is reported. The central step in the synthetic sequence is a diastereoselective intramolecular Heck reaction in which the substituent controlling stereoselection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af97796ad84a94f9740175946e9a57d
https://doi.org/10.1016/j.tet.2007.05.127
https://doi.org/10.1016/j.tet.2007.05.127