Výsledky vyhledávání - "Steven P Swanson"

Akademický článek

The immunogenicity of human-origin therapeutic antibodies are associated with V gene usage

Autor: Zicheng Hu, Sivan Cohen, Steven J. Swanson

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Therapeutic antibodies can elicit unwanted immune responses in a subset of patients, which leads to the production of anti-drug antibodies (ADA). Some of these ADAs have been reported to effect the pharmacokinetics, efficacy and/or safety of the ther

Externí odkaz: https://doaj.org/article/c1b9707ae39d4189929d30c1b14fcfcd

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Akademický článek

Oligo(Lactic Acid)8-Docetaxel Prodrug-Loaded PEG-b-PLA Micelles for Prostate Cancer

Autor: Lauren Repp, Christopher J. Unterberger, Zhengqing Ye, John B. Feltenberger, Steven M. Swanson, Paul C. Marker, Glen S. Kwon

Publikováno v: Nanomaterials, Vol 11, Iss 10, p 2745 (2021)

Docetaxel (DTX) is among the most frequently prescribed chemotherapy drugs and has recently been shown to extend survival in advanced prostate cancer patients. However, the poor water solubility of DTX prevents full exploitation of this potent antica

Externí odkaz: https://doaj.org/article/1aee56640a144de084baf3208fc1ab00

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Akademický článek

Development and Preclinical Application of an Immunocompetent Transplant Model of Basal Breast Cancer with Lung, Liver and Brain Metastases.

Autor: Olga Aprelikova, Christine C Tomlinson, Mark Hoenerhoff, Julie A Hixon, Scott K Durum, Ting-Hu Qiu, Siping He, Sandra Burkett, Zi-Yao Liu, Steven M Swanson, Jeffrey E Green

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0155262 (2016)

Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is associated with a poor prognosis and for which no targeted therapies currently exist. In order to improve preclinical testing for TNBC that relies primarily on usi

Externí odkaz: https://doaj.org/article/6cbcebf108f04e098e704c0eee495b7b

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Akademický článek

Biochemical and Anti-Triple Negative Metastatic Breast Tumor Cell Properties of Psammaplins

Autor: Yu-Dong Zhou, Jun Li, Lin Du, Fakhri Mahdi, Thuy P. Le, Wei-Lun Chen, Steven M. Swanson, Kounosuke Watabe, Dale G. Nagle

Publikováno v: Marine Drugs, Vol 16, Iss 11, p 442 (2018)

Breast tumors reprogram their cellular metabolism, nutrient uptake, and utilization-associated biochemical processes. These processes become further transformed as genetically predisposed metastatic breast tumor cells colonize specific organs. Breast

Externí odkaz: https://doaj.org/article/7f84aebf78ef426cb74e0e25fc4ec216

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Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1S,2S,4S,5R,6S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist

Publikováno v: Journal of Medicinal Chemistry. 61:2303-2328

Multiple therapeutic opportunities have been suggested for compounds capable of selective activation of metabotropic glutamate 3 (mGlu3) receptors, but small molecule tools are lacking. As part of our ongoing efforts to identify potent, selective, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34fd3a986aac486e41e6ea738f1a4465
https://doi.org/10.1021/acs.jmedchem.7b01481

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The 5-Hydroxytryptamine2A Receptor Antagonist R-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) Attenuates Impulsivity after Both Drug-Induced Disruption (Dizocilpine) and Enhancement (Antidepressant Drugs) of Differential-Reinforcement-of-Low-Rate 72-s Behavior in the Rat

Autor: Patrick L. Love, Paul A. Ardayfio, John T. Catlow, Mark J. Benvenga, Stephen F. Chaney, Steven P. Swanson, Gerard J. Marek

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 327:891-897

Previous work has suggested that N-methyl-d-aspartate (NMDA) receptor antagonism and 5-hydroxytryptamine (5-HT)(2A) receptor blockade may enhance and attenuate, respectively, certain types of impulsivity mediated by corticothalamostriatal circuits. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824e91454d9be3849159cd7a5ec0e700
https://doi.org/10.1124/jpet.108.143370

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N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes

Publikováno v: The Journal of pharmacology and experimental therapeutics. 336(1)

The normalization of excessive glutamatergic neurotransmission through the activation of metabotropic glutamate 2 (mGlu2) receptors may have therapeutic potential in a variety of psychiatric disorders, including anxiety/depression and schizophrenia.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91597fbae3f35360c2e3013a51d98d9
https://pubmed.ncbi.nlm.nih.gov/20947638

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Determination of olanzapine in human breast milk by high-performance liquid chromatography with electrochemical detection

Autor: Edward L. Mattiuz, Stephen C. Kasper, Steven P Swanson, Jason T. Johnson, Carlos Garner, Jenting Andre Chiu

Publikováno v: Journal of chromatography. B, Biomedical sciences and applications. 726(1-2)

A reversed-phase high-performance liquid chromatographic-electrochemical assay was developed and validated for the quantification of olanzapine in human breast milk. The assay involved a solid-phase extraction (SPE) of olanzapine and its internal sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e03910c2c084ab7cd2870b78393a4b
https://pubmed.ncbi.nlm.nih.gov/10348187

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Analysis of olanzapine in human plasma utilizing reversed-phase high-performance liquid chromatography with electrochemical detection

Autor: Steven P. Swanson, Matt Clements, Michael Goodwin, John T. Catlow, Todd A. Gillespie, Richard D. Barton

Publikováno v: Journal of chromatography. B, Biomedical applications. 668(1)

A sensitive reversed-phase HPLC method for the analysis of olanzapine in human plasma is described. Isolation of olanzapine from plasma was accomplished by solid-phase extraction utilizing an ion-exchange/reversed-phase cartridge designed for basic d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763bf92e573e94db24fcbbd10d7657d8
https://pubmed.ncbi.nlm.nih.gov/7550985

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Biotransformation of Trichothecenes: The Role of Intestinal Microflora in the Metabolism and Toxicity of Trichothecene Mycotoxins

Autor: C. Helaszek, Harold D. Rood, Steven P. Swanson

Publikováno v: Microbial Toxins in Foods and Feeds ISBN: 9781461279167

The trichothecene mycotoxins are a group of tetracyclic sesquiterpenoid compounds characterized by a six-membered oxygen ring, an epoxide in the 12,13 position and an olefinic bond in the 9,10 position. They are produced by a variety of fungi includi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a569fbe5ded69966a0e45316e090eba1
https://doi.org/10.1007/978-1-4613-0663-4_43

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