Zobrazeno 1 - 10
of 814
pro vyhledávání: '"Steven P Gygi"'
Autor:
Jonathan G Van Vranken, Jiaming Li, Julian Mintseris, Ting-Yu Wei, Catherine M Sniezek, Meagan Gadzuk-Shea, Steven P Gygi, Devin K Schweppe
Publikováno v:
eLife, Vol 13 (2024)
In response to an ever-increasing demand of new small molecules therapeutics, numerous chemical and genetic tools have been developed to interrogate compound mechanism of action. Owing to its ability to approximate compound-dependent changes in therm
Externí odkaz:
https://doaj.org/article/8bf3b9c5353e41d7be11802c16d7f60c
Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation
Autor:
Wayne Mitchell, Ludger JE Goeminne, Alexander Tyshkovskiy, Sirui Zhang, Julie Y Chen, Joao A Paulo, Kerry A Pierce, Angelina H Choy, Clary B Clish, Steven P Gygi, Vadim N Gladyshev
Publikováno v:
eLife, Vol 12 (2024)
Partial reprogramming by cyclic short-term expression of Yamanaka factors holds promise for shifting cells to younger states and consequently delaying the onset of many diseases of aging. However, the delivery of transgenes and potential risk of tera
Externí odkaz:
https://doaj.org/article/c3386c2215b54367bf7d646d779bdae7
Autor:
Yeyun Ouyang, Mi-Young Jeong, Corey N Cunningham, Jordan A Berg, Ashish G Toshniwal, Casey E Hughes, Kristina Seiler, Jonathan G Van Vranken, Ahmad A Cluntun, Geanette Lam, Jacob M Winter, Emel Akdogan, Katja K Dove, Sara M Nowinski, Matthew West, Greg Odorizzi, Steven P Gygi, Cory D Dunn, Dennis R Winge, Jared Rutter
Publikováno v:
eLife, Vol 13 (2024)
Mitochondrial membrane potential directly powers many critical functions of mitochondria, including ATP production, mitochondrial protein import, and metabolite transport. Its loss is a cardinal feature of aging and mitochondrial diseases, and cells
Externí odkaz:
https://doaj.org/article/a768575b342e486882ab0a8fb210d2a4
Publikováno v:
eLife, Vol 10 (2021)
Recent advances in mass spectrometry (MS) have enabled quantitative proteomics to become a powerful tool in the field of drug discovery, especially when applied toward proteome-wide target engagement studies. Similar to temperature gradients, increas
Externí odkaz:
https://doaj.org/article/9eaf719877654e798fcc33f219285582
Autor:
Vidyasiri Vemulapalli, Lily A Chylek, Alison Erickson, Anamarija Pfeiffer, Khal-Hentz Gabriel, Jonathan LaRochelle, Kartik Subramanian, Ruili Cao, Kimberley Stegmaier, Morvarid Mohseni, Matthew J LaMarche, Michael G Acker, Peter K Sorger, Steven P Gygi, Stephen C Blacklow
Publikováno v:
eLife, Vol 10 (2021)
SHP2 is a protein tyrosine phosphatase that normally potentiates intracellular signaling by growth factors, antigen receptors, and some cytokines, yet is frequently mutated in human cancer. Here, we examine the role of SHP2 in the responses of breast
Externí odkaz:
https://doaj.org/article/653eeb5ad6e5454e9488ec62514b8bc7
Autor:
Yuka Takemon, Joel M Chick, Isabela Gerdes Gyuricza, Daniel A Skelly, Olivier Devuyst, Steven P Gygi, Gary A Churchill, Ron Korstanje
Publikováno v:
eLife, Vol 10 (2021)
Little is known about the molecular changes that take place in the kidney during the aging process. In order to better understand these changes, we measured mRNA and protein levels in genetically diverse mice at different ages. We observed distinctiv
Externí odkaz:
https://doaj.org/article/890b27ddf1e64386900475149093834c
Autor:
Sara M Nowinski, Ashley Solmonson, Scott F Rusin, J Alan Maschek, Claire L Bensard, Sarah Fogarty, Mi-Young Jeong, Sandra Lettlova, Jordan A Berg, Jeffrey T Morgan, Yeyun Ouyang, Bradley C Naylor, Joao A Paulo, Katsuhiko Funai, James E Cox, Steven P Gygi, Dennis R Winge, Ralph J DeBerardinis, Jared Rutter
Publikováno v:
eLife, Vol 9 (2020)
Cells harbor two systems for fatty acid synthesis, one in the cytoplasm (catalyzed by fatty acid synthase, FASN) and one in the mitochondria (mtFAS). In contrast to FASN, mtFAS is poorly characterized, especially in higher eukaryotes, with the major
Externí odkaz:
https://doaj.org/article/f28d705b3f05490b91c7e479d58b568b
Publikováno v:
eLife, Vol 9 (2020)
Heterochromatic domains containing histone H3 lysine 9 methylation (H3K9me) can be epigenetically inherited independently of underlying DNA sequence. To gain insight into the mechanisms that mediate epigenetic inheritance, we used a Schizosaccharomyc
Externí odkaz:
https://doaj.org/article/81905807a78d47b6ae44e1920d3ae94d
Autor:
Anna Motnenko, Chih-Chao Liang, Di Yang, David Lopez-Martinez, Yasunaga Yoshikawa, Bao Zhan, Katherine E Ward, Jiayang Tian, Wilhelm Haas, Paolo Spingardi, Benedikt M Kessler, Skirmantas Kriaucionis, Steven P Gygi, Martin A Cohn
Publikováno v:
PLoS Genetics, Vol 14, Iss 10, p e1007643 (2018)
The Fanconi Anemia (FA) pathway is important for repairing interstrand crosslinks (ICLs) between the Watson-Crick strands of the DNA double helix. An initial and essential stage in the repair process is the detection of the ICL. Here, we report the i
Externí odkaz:
https://doaj.org/article/0732015a852349df980e56c133ef0fcb
Autor:
Ahmed I Mahmoud, Francisco X Galdos, Katherine A Dinan, Mark P Jedrychowski, Jeffrey C Davis, Ana Vujic, Inbal Rachmin, Christian Shigley, James R Pancoast, Samuel Lee, Jennifer Hollister-Lock, Catherine M MacGillivray, Steven P Gygi, Douglas A Melton, Gordon C Weir, Richard T Lee
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204595 (2018)
The in vivo microenvironment of tissues provides myriad unique signals to cells. Thus, following isolation, many cell types change in culture, often preserving some but not all of their in vivo characteristics in culture. At least some of the in vivo
Externí odkaz:
https://doaj.org/article/105ba49f67b348fb8916c00f5caeeb50