A role for Tn6029 in the evolution of the complex antibiotic resistance gene loci in genomic island 3 in enteroaggregative hemorrhagic Escherichia coli O104:H4.

Autor: Piklu Roy Chowdhury, Ian G Charles, Steven P Djordjevic

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0115781 (2015)

In enteroaggregative hemorrhagic Escherichia coli (EAHEC) O104 the complex antibiotic resistance gene loci (CRL) found in the region of divergence 1 (RD1) within E. coli genomic island 3 (GI3) contains blaTEM-1, strAB, sul2, tet(A)A, and dfrA7 genes

Externí odkaz: https://doaj.org/article/7d56743f7558436f9312329a7a8a528a

Sequences of two related multiple antibiotic resistance virulence plasmids sharing a unique IS26-related molecular signature isolated from different Escherichia coli pathotypes from different hosts.

Autor: Carola Venturini, Karl A Hassan, Piklu Roy Chowdhury, Ian T Paulsen, Mark J Walker, Steven P Djordjevic

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e78862 (2013)

Enterohemorrhagic Escherichia coli (EHEC) and atypical enteropathogenic E. coli (aEPEC) are important zoonotic pathogens that increasingly are becoming resistant to multiple antibiotics. Here we describe two plasmids, pO26-CRL125 (125 kb) from a huma

Externí odkaz: https://doaj.org/article/d9f149917a6b4b008543618986422fb0

Distribution of class 1 integrons with IS26-mediated deletions in their 3'-conserved segments in Escherichia coli of human and animal origin.

Autor: Fay E Dawes, Alexander Kuzevski, Karl A Bettelheim, Michael A Hornitzky, Steven P Djordjevic, Mark J Walker

Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12754 (2010)

Class 1 integrons play a role in the emergence of multi-resistant bacteria by facilitating the recruitment of gene cassettes encoding antibiotic resistance genes. 512 E. coli strains sourced from humans (n = 202), animals (n = 304) and the environmen

Externí odkaz: https://doaj.org/article/3779e75a952644cfafec25ffe58140e7

Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

Autor: Andre Mu, William P. Klare, Sarah L. Baines, C. N. Ignatius Pang, Romain Guérillot, Nichaela Harbison-Price, Nadia Keller, Jonathan Wilksch, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Bernhard Keller, Brunda Nijagal, Dedreia Tull, Saravanan Dayalan, Hwa Huat Charlie Chua, Dominik Skoneczny, Jason Koval, Abderrahman Hachani, Anup D. Shah, Nitika Neha, Snehal Jadhav, Sally R. Partridge, Amanda J. Cork, Kate Peters, Olivia Bertolla, Stephan Brouwer, Steven J. Hancock, Laura Álvarez-Fraga, David M. P. De Oliveira, Brian Forde, Ashleigh Dale, Warasinee Mujchariyakul, Calum J. Walsh, Ian Monk, Anna Fitzgerald, Mabel Lum, Carolina Correa-Ospina, Piklu Roy Chowdhury, Robert G. Parton, James De Voss, James Beckett, Francois Monty, Jessica McKinnon, Xiaomin Song, John R. Stephen, Marie Everest, Matt I. Bellgard, Matthew Tinning, Michael Leeming, Dianna Hocking, Leila Jebeli, Nancy Wang, Nouri Ben Zakour, Serhat A. Yasar, Stefano Vecchiarelli, Tonia Russell, Thiri Zaw, Tyrone Chen, Don Teng, Zena Kassir, Trevor Lithgow, Adam Jenney, Jason N. Cole, Victor Nizet, Tania C. Sorrell, Anton Y. Peleg, David L. Paterson, Scott A. Beatson, Jemma Wu, Mark P. Molloy, Anna E. Syme, Robert J. A. Goode, Adam A. Hunter, Grahame Bowland, Nicholas P. West, Marc R. Wilkins, Steven P. Djordjevic, Mark R. Davies, Torsten Seemann, Benjamin P. Howden, Dana Pascovici, Sonika Tyagi, Ralf B. Schittenhelm, David P. De Souza, Malcolm J. McConville, Jonathan R. Iredell, Stuart J. Cordwell, Richard A. Strugnell, Timothy P. Stinear, Mark A. Schembri, Mark J. Walker

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Severe sepsis has a high mortality rate. Here, the authors provide genomic, transcriptomic, proteomic and metabolomic data across four sepsis-causing pathogens and identify a signature of global increase in fatty acid and lipid biosynthesis as well a

Externí odkaz: https://doaj.org/article/6d65b18b91de403488fe5eca204df6be

Development of Nanoparticle Adaptation Phenomena in Acinetobacter baumannii: Physiological Change and Defense Response

Autor: Oliver McNeilly, Riti Mann, Max Laurence Cummins, Steven P. Djordjevic, Mehrad Hamidian, Cindy Gunawan

Publikováno v: Microbiology Spectrum, Vol 11, Iss 1 (2023)

ABSTRACT The present work describes the evolution of a resistance phenotype to a multitargeting antimicrobial agent, namely, silver nanoparticles (nanosilver; NAg), in the globally prevalent bacterial pathogen Acinetobacter baumannii. The Gram-negati

Externí odkaz: https://doaj.org/article/2004b3913da7419a8cb49c7fa3b4411f