Zobrazeno 1 - 10
of 810
pro vyhledávání: '"Steven P, Gygi"'
Autor:
Chrysanthi Kagiou, Jose A. Cisneros, Jakob Farnung, Joanna Liwocha, Fabian Offensperger, Kevin Dong, Ka Yang, Gary Tin, Christina S. Horstmann, Matthias Hinterndorfer, Joao A. Paulo, Natalie S. Scholes, Juan Sanchez Avila, Michaela Fellner, Florian Andersch, J. Thomas Hannich, Johannes Zuber, Stefan Kubicek, Steven P. Gygi, Brenda A. Schulman, Georg E. Winter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Targeted protein degradation (TPD) relies on small molecules to recruit proteins to E3 ligases to induce their ubiquitylation and degradation by the proteasome. Only a few of the approximately 600 human E3 ligases are currently amenable to t
Externí odkaz:
https://doaj.org/article/122c230e01c4426bb2025a22bb1c70c0
Autor:
Jonas D. Albarnaz, Joanne Kite, Marisa Oliveira, Hanqi Li, Ying Di, Maria H. Christensen, Joao A. Paulo, Robin Antrobus, Steven P. Gygi, Florian I. Schmidt, Edward L. Huttlin, Geoffrey L. Smith, Michael P. Weekes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Modified vaccinia Ankara (MVA) virus does not replicate in human cells and is the vaccine deployed to curb the current outbreak of mpox. Here, we conduct a multiplexed proteomic analysis to quantify >9000 cellular and ~80% of viral proteins
Externí odkaz:
https://doaj.org/article/c5eb5a2f13b44fa3a6446d25a2216f50
Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation
Autor:
Wayne Mitchell, Ludger JE Goeminne, Alexander Tyshkovskiy, Sirui Zhang, Julie Y Chen, Joao A Paulo, Kerry A Pierce, Angelina H Choy, Clary B Clish, Steven P Gygi, Vadim N Gladyshev
Publikováno v:
eLife, Vol 12 (2024)
Partial reprogramming by cyclic short-term expression of Yamanaka factors holds promise for shifting cells to younger states and consequently delaying the onset of many diseases of aging. However, the delivery of transgenes and potential risk of tera
Externí odkaz:
https://doaj.org/article/c3386c2215b54367bf7d646d779bdae7
Autor:
Yeyun Ouyang, Mi-Young Jeong, Corey N Cunningham, Jordan A Berg, Ashish G Toshniwal, Casey E Hughes, Kristina Seiler, Jonathan G Van Vranken, Ahmad A Cluntun, Geanette Lam, Jacob M Winter, Emel Akdogan, Katja K Dove, Sara M Nowinski, Matthew West, Greg Odorizzi, Steven P Gygi, Cory D Dunn, Dennis R Winge, Jared Rutter
Publikováno v:
eLife, Vol 13 (2024)
Mitochondrial membrane potential directly powers many critical functions of mitochondria, including ATP production, mitochondrial protein import, and metabolite transport. Its loss is a cardinal feature of aging and mitochondrial diseases, and cells
Externí odkaz:
https://doaj.org/article/a768575b342e486882ab0a8fb210d2a4
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Organelles are shaped by curvature-generating proteins, which include the reticulons and REEPs that are involved in forming the endoplasmic reticulum (ER). A conserved REEP subfamily differs from the ER-shaping REEPs in abundance and membran
Externí odkaz:
https://doaj.org/article/28a5bfedb90046b8b2af29820a0e4f94
Autor:
Lydie Naulé, Alessandra Mancini, Sidney A. Pereira, Brandon M. Gassaway, John R. Lydeard, Kayleigh Rutherford, John C. Magnotto, Han Kyeol Kim, Joy Liang, Cynara Matos, Steven P. Gygi, Florian T. Merkle, Rona S. Carroll, Ana Paula Abreu, Ursula B. Kaiser
Publikováno v:
JCI Insight, Vol 8, Iss 8 (2023)
Makorin ring finger protein 3 (MKRN3) was identified as an inhibitor of puberty initiation with the report of loss-of-function mutations in association with central precocious puberty. Consistent with this inhibitory role, a prepubertal decrease in M
Externí odkaz:
https://doaj.org/article/8384957a66c14bedb6b66a209226aef3
Autor:
Utsarga Adhikary, Joao A. Paulo, Marina Godes, Shrabasti Roychoudhury, Michelle S. Prew, Yael Ben-Nun, Ellen W. Yu, Amit Budhraja, Joseph T. Opferman, Dipanjan Chowdhury, Steven P. Gygi, Loren D. Walensky
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113176- (2023)
Summary: MCL-1 is a high-priority target due to its dominant role in the pathogenesis and chemoresistance of cancer, yet clinical trials of MCL-1 inhibitors are revealing toxic side effects. MCL-1 biology is complex, extending beyond apoptotic regula
Externí odkaz:
https://doaj.org/article/8e604e1e9c314f39806640bf06f448b9
Autor:
Tian Zhang, Gregory R. Keele, Isabela Gerdes Gyuricza, Matthew Vincent, Catherine Brunton, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Steven C. Munger, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Joao A. Paulo, Steven P. Gygi, Gary A. Churchill
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-29 (2023)
Abstract Background Phosphorylation of proteins is a key step in the regulation of many cellular processes including activation of enzymes and signaling cascades. The abundance of a phosphorylated peptide (phosphopeptide) is determined by the abundan
Externí odkaz:
https://doaj.org/article/812d1f4d20a34130b1e4a7ae5bae7fb5
Autor:
Qing Yu, Xinyue Liu, Mark P. Keller, Jose Navarrete-Perea, Tian Zhang, Sipei Fu, Laura P. Vaites, Steven R. Shuken, Ernst Schmid, Gregory R. Keele, Jiaming Li, Edward L. Huttlin, Edrees H. Rashan, Judith Simcox, Gary A. Churchill, Devin K. Schweppe, Alan D. Attie, Joao A. Paulo, Steven P. Gygi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Targeted proteomics enables robust hypothesis-driven research. Here, Yu et al. present a multiplexed approach for targeted pathway proteomics and apply it to quantify protein families across 480 fully genotyped Diversity Outbred mice, revealing impac
Externí odkaz:
https://doaj.org/article/cd1a101b49ee4dfbb34edecc65790389
Autor:
Gregory R. Keele, Ji-Gang Zhang, John Szpyt, Ron Korstanje, Steven P. Gygi, Gary A. Churchill, Devin K. Schweppe
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112715- (2023)
Summary: Maintenance of protein homeostasis degrades with age, contributing to aging-related decline and disease. Previous studies have primarily surveyed transcriptional aging changes. To define the effects of age directly at the protein level, we p
Externí odkaz:
https://doaj.org/article/0ebf66b87b984c858446f29df12b141a