Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Steven O. Smith"'
Autor:
Feng Xu, Ziao Fu, Sharmila Dass, AnnMarie E. Kotarba, Judianne Davis, Steven O. Smith, William E. Van Nostrand
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/4c4318f866c04a85a340f94258adde7a
Autor:
Xiaoyue Zhu, Joseph M. Schrader, Brandon A. Irizarry, Steven O. Smith, William E. Van Nostrand
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2982 (2022)
Fibrillar amyloid β-protein (Aβ) deposits in the brain, which are primarily composed of Aβ40 or Aβ42 peptides, are key pathological features of Alzheimer’s disease (AD) and related disorders. Although the underlying mechanisms are still not cle
Externí odkaz:
https://doaj.org/article/f9e72154e7304181be9bc76737c5cf89
Autor:
Florian Perrin, Nicolas Papadopoulos, Nuria Suelves, Rémi Opsomer, Devkee M. Vadukul, Céline Vrancx, Steven O. Smith, Didier Vertommen, Pascal Kienlen-Campard, Stefan N. Constantinescu
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102057- (2021)
Externí odkaz:
https://doaj.org/article/f665fef4c70b4f3dab58560ad815f4ab
Autor:
Florian Perrin, Nicolas Papadopoulos, Nuria Suelves, Rémi Opsomer, Devkee M. Vadukul, Céline Vrancx, Steven O. Smith, Didier Vertommen, Pascal Kienlen-Campard, Stefan N. Constantinescu
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101887- (2020)
Summary: Amyloid precursor protein (APP) cleavage by the β-secretase produces the C99 transmembrane (TM) protein, which contains three dimerization-inducing Gly-x-x-x-Gly motifs. We demonstrate that dimeric C99 TM orientations regulate the precise c
Externí odkaz:
https://doaj.org/article/0dd44fb254d34538a6340aed44bc05be
Autor:
Feng Xu, Ziao Fu, Sharmila Dass, AnnMarie E. Kotarba, Judianne Davis, Steven O. Smith, William E. Van Nostrand
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Abstract Cerebrovascular accumulation of amyloid β-protein (Aβ), a condition known as cerebral amyloid angiopathy (CAA), is a common pathological feature of patients with Alzheimer’s disease. Familial Aβ mutations, such as Dutch-E22Q and Iowa-D2
Externí odkaz:
https://doaj.org/article/483f3bd3cd8348caa0a28e98e8525ac8
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1225 (2021)
The amyloid-β (Aβ) peptides are associated with two prominent diseases in the brain, Alzheimer’s disease (AD) and cerebral amyloid angiopathy (CAA). Aβ42 is the dominant component of cored parenchymal plaques associated with AD, while Aβ40 is t
Externí odkaz:
https://doaj.org/article/9174b553c51a452996bc0a3f59170530
Autor:
Naoki Kimata, Andreyah Pope, Markus Eilers, Chikwado A. Opefi, Martine Ziliox, Amiram Hirshfeld, Ekaterina Zaitseva, Reiner Vogel, Mordechai Sheves, Philip J. Reeves, Steven O. Smith
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Rhodopsin signalling is triggered by the light-induced isomerization of its 11-cisretinal chromophore. Here, the authors use NMR spectroscopy to define retinal orientation and interactions in the active metarhodopsin II intermediate, proposing a two-
Externí odkaz:
https://doaj.org/article/68145e548cf44632bc7c5e853a70c0e6
Autor:
Marie Decock, Laetitia El Haylani, Serena Stanga, Ilse Dewachter, Jean-Noël Octave, Steven O. Smith, Stefan N. Constantinescu, Pascal Kienlen-Campard
Publikováno v:
FEBS Open Bio, Vol 5, Iss 1, Pp 763-773 (2015)
Alzheimer's disease (AD) is a neurodegenerative disease that causes progressive loss of cognitive functions, leading to dementia. Two types of lesions are found in AD brains: neurofibrillary tangles and senile plaques. The latter are composed mainly
Externí odkaz:
https://doaj.org/article/17de4ce661c4404e8961ebca1d556998
Autor:
Steven O. Smith
Publikováno v:
Annual Review of Biophysics. 52:301-317
Rhodopsin is the photoreceptor in human rod cells responsible for dim-light vision. The visual receptors are part of the large superfamily of G protein–coupled receptors (GPCRs) that mediate signal transduction in response to diverse diffusible lig
Autor:
Jitika Rajpoot, Elliot J. Crooks, Brandon A. Irizarry, Ashley Amundson, William E. Van Nostrand, Steven O. Smith
Publikováno v:
Biochemistry. 61:1181-1198
Two distinct diseases are associated with the deposition of fibrillar amyloid-β (Aβ) peptides in the human brain in an age-dependent fashion. Alzheimer's disease is primarily associated with parenchymal plaque deposition of Aβ42, while cerebral am