Motor, Visual and Emotional Deficits in Mice after Closed-Head Mild Traumatic Brain Injury Are Alleviated by the Novel CB2 Inverse Agonist SMM-189

Autor: Chaela S. Presley, Jessica Ferrell, Nobel Del Mar, Yunping Deng, Lauren D'Surney, Steven N. Gurley, Natalie H. Guley, Wei Bu, Scott A. Heldt, Andrea J. Elberger, Anton Reiner, Marcia G. Honig, Bob M. Moore, Joshua T. Rogers

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 16, Iss 1, Pp 758-787 (2014)
Volume 16
Issue 1
Pages 758-787

We have developed a focal blast model of closed-head mild traumatic brain injury (TBI) in mice. As true for individuals that have experienced mild TBI, mice subjected to 50–60 psi blast show motor, visual and emotional deficits, diffuse axonal inju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a6334553fa453f9cb8e0fdcfae4a54
https://doi.org/10.3390/ijms16010758

Exploring the substituent effects on a novel series of C1′-dimethyl-aryl Δ8-tetrahydrocannabinol analogs

Autor: Steven N. Gurley, Mathangi Krishnamurthy, Bob M. Moore

Publikováno v: Bioorganic & Medicinal Chemistry. 16:6489-6500

The synthesis and characterization of novel C1'-phenyl-substituted Delta(8)-THC analogs were previously reported by our laboratory. Within this small series of compounds, the C1'-dimethyl phenyl group was found to impart 13.5-fold selectivity for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873538fd9e2aa13149c19173c6948840
https://doi.org/10.1016/j.bmc.2008.05.034

Motor, Visual and Emotional Deficits in Mice after Closed-Head Mild Traumatic Brain Injury Are Alleviated by the Novel CB2 Inverse Agonist SMM-189.

Autor: Reiner, Anton^1,2 areiner@uthsc.edu, Heldt, Scott A.¹ sheldt@uthsc.edu, Presley, Chaela S.³ cpresle4@uthsc.edu, Guley, Natalie H.¹ nhart2@uthsc.edu, Elberger, Andrea J.¹ aelberge@uthsc.edu, Yunping Deng¹ ydeng@uthsc.edu, D'Surney, Lauren¹ ldsurney@uthsc.edu, Rogers, Joshua T.¹ jroger45@uthsc.edu, Ferrell, Jessica¹ jferre13@uthsc.edu, Wei Bu¹ wbu1@uthsc.edu, Mar, Nobel Del¹ ndelmar@uthsc.edu, Honig, Marcia G.¹ mhonig@uthsc.edu, Gurley, Steven N.³ sngurley@comcast.net, Moore II, Bob M.³ bmoore@uthsc.edu

Publikováno v: International Journal of Molecular Sciences. 2015, Vol. 16 Issue 1, p758-787. 30p. 4 Color Photographs, 8 Graphs.