Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Steven N. Chatfield"'
Autor:
Zoë Hindle, Catherine J. Larsson, J. Patrick O'Neill, Matthew Bentley, Casey LaPointe, Sandra Hamlet, Katherine M. Tenney, Regan Holdridge, Anthony Upton, Deborah Kutzko, Cassandra H. Ventrone, Steven N. Chatfield, Christine Fidler, Beth D. Kirkpatrick
Publikováno v:
The Journal of Infectious Diseases. 192:360-366
BACKGROUND M01ZH09 (Salmonella enterica serovar Typhi [Ty2 aroC(-) ssaV(-)] ZH9) is a live oral-dose typhoid vaccine candidate. M01ZH09 was rationally modified with 2 independently attenuating mutations, including a novel mutation in Salmonella patho
Autor:
Frank R. Brennan, Shahid A. Khan, Emma Aldred, Zoë Hindle, Nicky J. Hughes, Trevor Bellaby, Johanna Curtis, Claire Wiseman, Gordon Dougan, Steven N. Chatfield, Richard Stratford, Nicola D. McKelvie, Matthew Bentley
Publikováno v:
Infection and Immunity. 73:362-368
Novel candidate live oral vaccines based on aSalmonella entericaserovar Typhi ZH9 (Ty2 ΔaroCΔssaV) derivative that directed the expression of either the B subunit ofEscherichia coliheat-labile toxin or hepatitis B virus core antigen from the bacter
Autor:
Jaqueline E. Shea, David Lewis, J. D. Johnson, Derek Pickard, Gordon Dougan, Jo Phillimore, Joseph D. Santangelo, Zoë Hindle, Marjan Ghaem-Maghami, Robert G. Feldman, Matthew Bentley, David W. Holden, Steven N. Chatfield, Tao Wu, Shahid A. Khan, Mohammad Akbar Khan, George E. Griffin, Amy Sexton, Catherine Cosgrove, Deborah House, Frank R. Brennan, Paul Everest
Publikováno v:
Infection and Immunity. 70:3457-3467
The attenuation and immunogenicity of two novel Salmonella vaccine strains, Salmonella enterica serovar Typhi (Ty2 Δ aroC Δ ssaV , designated ZH9) and S. enterica serovar Typhimurium (TML Δ aroC Δ ssaV , designated WT05), were evaluated after the
Publikováno v:
Infection and Immunity. 67:3810-3815
We have investigated the effect of preexisting immunity to homologous ( Salmonella typhimurium ) or heterologous ( S. dublin ) serotypes of Salmonella on the ability of an attenuated S. typhimurium aroA aroD vector (BRD509) to immunize mice against t
Autor:
Matthew Bentley, Edward Cahill, Mark Page, Steven N. Chatfield, Christopher D Jones, Andrew Bacon
Publikováno v:
Vaccine. 17:2528-2537
The incidence of non-responders to hepatitis B (HB) virus SHBs antigen (Ag) vaccines has prompted the development of pre-S containing vaccines. The aim of this study was to characterise the murine immune response to a novel recombinant particle (Hepa
Publikováno v:
Journal of Viral Hepatitis. 5:5-8
Hepagene is a novel recombinant particle consisting of the pre-S1, pre-S2 and small surface (SHBs) antigens (Ag) of the hepatitis B virus (HBV) and is adjuvanted with alhydrogel in the final formulation. It has been primarily developed to enhance ant
Autor:
Mariarosaria Marinaro, Raymond J. Jackson, John L. VanCott, Steven N. Chatfield, Kohtaro Fujihashi, Masafumi Yamamoto, Nobuo Okahashi, Jerry R. McGhee, Hiroshi Kiyono
Publikováno v:
Journal of Biotechnology. 44:209-216
The mechanisms which regulate mucosal IgA responses to orally administered protein vaccines are not yet fully elucidated. We have used two delivery systems, soluble tetanus toxoid (TT) with the mucosal adjuvant cholera toxin (CT) and recombinant Salm
Autor:
James E. Galen, Carol O. Tacket, Myron M. Levine, Fernando R. Noriega, Gordon Dougan, Marcelo B. Sztein, Steven N. Chatfield, Eileen M. Barry
Publikováno v:
Journal of Biotechnology. 44:193-196
Attenuated Salmonella typhi vaccine strain CVD 908, which harbors deletion mutations in aroC and aroD, has been shown to be well-tolerated and highly immunogenic, eliciting impressive serum antibody, mucosal IgA and cell-mediated immune responses. A
Autor:
James E. Galen, Oscar G. Gómez-Duarte, Rino Rappuoli, Myron M. Levine, Leon Eidels, Steven N. Chatfield
Publikováno v:
Vaccine. 13:1596-1602
We report the expression of fragment C of tetanus toxin (FC) fused to the eukaryotic cell binding domain (the carboxyl-terminus) of diphtheria toxin (FC-bDt fusion) in attenuated Salmonella typhi live vector vaccine strain CVD 908. The FC-bDt protein
Autor:
M. Levine, D. Hone, Mark L. Roberts, Duncan Maskell, G. Dougan, Steven N. Chatfield, Derek Pickard, Jingli Li
Publikováno v:
Infection and Immunity. 62:3984-3993
The ompB operon, comprising the ompR and envZ genes, was cloned from a Salmonella typhi Ty2 cosmid bank and characterized by DNA sequence analysis. The S. typhi ompR and envZ genes contained open reading frames encoding proteins of 240 and 451 amino