Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Steven M. Townson"'
Autor:
Jung-Yun Lee, Maria Bell, Mariusz Bidzinski, Lubomir Bodnar, Jack Junjie Chan, Marta Gill-Martin, Carolina Ibanez, Domenica Lorusso, Chien-Hsing Lu, Ora Rosengarten, Steven M. Townson, Julie Kobie, Yiwei Zhang, Scott Pruitt, Ronnie Shapira-Frommer
Publikováno v:
Cancer Research. 83:CT046-CT046
Background: Combination therapy with the anti-PD-1 monoclonal antibody (mAb) pembrolizumab and chemotherapy in advanced solid tumors has shown efficacy in the (neo)adjuvant and first-line setting, including high-grade serous ovarian cancer (HGSOC). T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea7f95db3e99ee864ee8cad28b148da6
https://doi.org/10.1158/1538-7445.am2023-ct046
https://doi.org/10.1158/1538-7445.am2023-ct046
Autor:
Jair Bar, Emilio Esteban, Delvys Rodríguez-Abreu, Santiago Ponce Aix, Zsuzsanna Szalai, Enriqueta Felip, Maya Gottfried, Mariano Provencio Pulla, Andrew Robinson, Andrea Fülöp, Suman B. Rao, D. Ross Camidge, Giovanna Speranza, Steven M. Townson, Julie Kobie, Mark Ayers, Elisha J. Dettman, Robert McDaniel, Byoungsok Jung, David Burkhardt, Ruth Mauntz, Tibor Csőszi
Publikováno v:
Cancer Research. 83:CT216-CT216
Background: 1L pembro + platinum-based chemo has shown clinical activity in metastatic NSCLC regardless of tissue tumor mutational burden (tTMB) status. bTMB assessed using circulating tumor DNA in plasma may be a surrogate for tTMB. The single-arm,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d03953df55679ccc5d10c91ce2098b5
https://doi.org/10.1158/1538-7445.am2023-ct216
https://doi.org/10.1158/1538-7445.am2023-ct216
Publikováno v:
Future oncology (London, England). 17(20)
Aim: Summarize the literature assessing biomarkers in predicting efficacy of anti-PD-1 therapy for patients with high-risk unresectable or metastatic melanoma. Materials & methods: Relevant studies were identified via a systematic literature review.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c394dfb2529278b1dd27e417d8c10c
https://pubmed.ncbi.nlm.nih.gov/33783230
https://pubmed.ncbi.nlm.nih.gov/33783230
Autor:
Wendy M. Blumenschein, Kelsey Baker, Bailey Donahue, Jennifer H. Yearley, Terrill K. McClanahan, Benjamin Hoch, Erin Murphy, Yuzheng Zhang, Marissa Vignali, Lee D. Cranmer, Stanley R. Riddell, Robin L. Jones, Sara Cooper, Matthew B. Spraker, Ryan O. Emerson, Seth M. Pollack, Steven M. Townson, Elizabeth T. Loggers, Qianchuan He, Y. David Seo, Venu G. Pillarisetty, Sharon Benzeno, Mary W. Redman, Robert W. Ricciotti
Publikováno v:
Cancer. 123:3291-3304
BACKGROUND Patients with metastatic sarcomas have poor outcomes and although the disease may be amenable to immunotherapies, information regarding the immunologic profiles of soft tissue sarcoma (STS) subtypes is limited. METHODS The authors identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1d2d7cbbc6341ae137a4fde740cd559
https://doi.org/10.1002/cncr.30726
https://doi.org/10.1002/cncr.30726
Autor:
Jeanne M. Fahey, Renganayaki Krishna Pandurengan, David R. Fogelman, James C. Yao, Milind Javle, Ella Sorani, Abi Vainstein-Haras, Steven M. Townson, Debora A. Ledesma, Osnat Kashtan, Mei Jiang, Yosi Gozlan, Michael J. Overman, Shubham Pant, Rachna T. Shroff, Ignacio I. Wistuba, Edwin R. Parra, Carmelia Maria Noia Barreto, Gauri R. Varadhachary, Tzipora M. Lustig, Robert A. Wolff, Swati Gite, Luisa M. Solis
Publikováno v:
Cancer Research. 80:CT204-CT204
Background: We recently conducted a clinical trial assessing Pembrolizumab (P) and BL-8040 (BL) in patients with pancreatic cancer. We prospectively collected serial biopsies to help understand the impact of this treatment on the tumor microenvironme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26557040b159c361b326348ff0d84cc1
https://doi.org/10.1158/1538-7445.am2020-ct204
https://doi.org/10.1158/1538-7445.am2020-ct204
Autor:
Michael J. Wagner, Sabrina McDonnell, Roxanne Moore, Lee D. Cranmer, Mary W. Redman, Elizabeth T. Loggers, Kelsey Baker, Robin L. Jones, Michael Shahnazari, Seth M. Pollack, Jeffrey Gregory, Vanessa C. Copeland, Steven M. Townson, Kathryn J. Hammer, Rylee Johnson
Publikováno v:
Journal of Clinical Oncology. 37:11009-11009
11009 Background: Patients with advanced soft tissue sarcomas (STS) treated with single agent Dox have a median progression-free survival (PFS) of 4.6 months (mo) and response rate (RR) of 14%. Dox sensitizes tumors to Pem through calreticulin releas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e51535042453890f5ddc845af8378e0a
https://doi.org/10.1200/jco.2019.37.15_suppl.11009
https://doi.org/10.1200/jco.2019.37.15_suppl.11009
Autor:
James C. Yao, David Ross Kaufman, David R. Fogelman, Milind Javle, Ella Sorani, Maureen E. Lane, Abi Vainstein Haras, Michael J. Overman, Steven M. Townson, Gauri R. Varadhachary, Tzipora M. Lustig, Linus Ho, Rachna T. Shroff, Robert A. Wolff
Publikováno v:
Journal of Clinical Oncology. 36:TPS533-TPS533
TPS533 Background: Checkpoint inhibitors such as pembrolizumab are active against a variety of tumor types; however, pancreatic cancer patients generally do not see improvements in their disease from single agent treatment. Blocking CXCR4 may potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a433b6fd0d7b6941de3f77c588650433
https://doi.org/10.1200/jco.2018.36.4_suppl.tps533
https://doi.org/10.1200/jco.2018.36.4_suppl.tps533
Publikováno v:
Journal of Biological Chemistry. 279:26074-26081
Scaffold attachment factor-B1 (SAFB1) is a nuclear matrix protein that has been proposed to couple chromatin structure, transcription, and RNA processing. We have previously shown that SAFB1 can repress estrogen receptor (ERalpha)-mediated transactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bcdc643f94739dd345d4d3fa6156a7d
https://doi.org/10.1074/jbc.m313726200
https://doi.org/10.1074/jbc.m313726200
Publikováno v:
Endocrine-related cancer. :517-536
Estrogen receptor alpha (ERalpha) has an established role in promoting breast cancer. Transcriptional activation by ERalpha is a complex and multistep process, and it is influenced by coactivator and corepressor proteins that can either positively or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4ab53ba66898a0eef6360f0d75e2ff
https://doi.org/10.1677/erc.0.0100517
https://doi.org/10.1677/erc.0.0100517
Autor:
Wendy M. Blumenschein, Venu G. Pillarisetty, Seth M. Pollack, Sharon Benzeno, Erin Murphy, Lee D. Cranmer, Benjamin Hoch, Mary W. Redman, Ryan O. Emerson, Steven M. Townson, Elizabeth T. Loggers, Marissa Vignali, Stanley R. Riddell, Jennifer H. Yearley, Robert W. Ricciotti, Qianchuan He, Robin L. Jones, Terrill K. McClanahan, Yuzheng Zhang
Publikováno v:
Journal of Clinical Oncology. 35:23-23
23 Background: The success of immunotherapy has raised new issues regarding the selection of patients, design of combination strategies, and sequencing of various regimens. Sarcomas have poor outcomes in the metastatic setting but may be amenable to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6236073f89830c50a71dac968c2ab18
https://doi.org/10.1200/jco.2017.35.7_suppl.23
https://doi.org/10.1200/jco.2017.35.7_suppl.23