Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Steven M. Torkelson"'
Autor:
Ellen Sanford, Roopa Rai, Steven M. Torkelson, William D. Shrader, Ronnell Cabuslay, Bradley A. Katz, Paul A. Sprengeler, Tony Ton, Aleksandr Kolesnikov, Robin Stephens, Wendy B. Young, Christine Yu, John Hendrix
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2270-2273
Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridin
Autor:
Aleksandr Kolesnikov, Ellen M. Leahy, James W. Janc, Joyce Mordenti, Wendy B. Young, Paul A. Sprengeler, Erik Gjerstad, William D. Shrader, Roopa Rai, Huiyong Hu, Steven M. Torkelson, Bradley A. Katz, Liang Liu
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(8)
Efforts to improve the potency and pharmacokinetic properties of small molecule factor VIIa inhibitors are described. Small structural modifications to existing leads allow the modulation of half-life and clearance, potentially making these compounds
Autor:
Bradley A. Katz, Paul A. Sprengeler, Liang Liu, Steven M. Torkelson, Huiyong Hu, William D. Shrader, Kyle Elrod, Christine Yu, Roopa Rai, Michael J. Green, Aleksandr Kolesnikov, Joyce Mordenti, Wendy B. Young, James W. Janc, Ellen M. Leahy, Ulla M. Marzec, Stephen R. Hanson
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(7)
Highly selective and potent factor VIIa–tissue factor (fVIIa · TF) complex inhibitors were generated through structure-based design. The pharmacokinetic properties of an optimized analog (9) were characterized in several preclinical species, demon