Výsledky vyhledávání - "Steven M. Russo"

Carbon Monoxide and Heme Oxygenase-1 Prevent Intestinal Inflammation in Mice by Promoting Bacterial Clearance

Autor: John F. Rawls, Steven M. Russo, Shehzad Z. Sheikh, Scott E. Plevy, Adam J. Moeser, Nitsan Maharshak, Jonathan J. Hansen, Leo E. Otterbein, Joseph C. Onyiah, Lantz C. Mackey, Luke B. Borst, Erin C. Steinbach, Taku Kobayashi

Publikováno v: Gastroenterology. 144:789-798

Background & Aims Heme oxygenase-1 (HO-1) and its metabolic by-product, carbon monoxide (CO), protect against intestinal inflammation in experimental models of colitis, but little is known about their intestinal immune mechanisms. We investigated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db42acebb0c245261c8bda1b81c1d878
https://doi.org/10.1053/j.gastro.2012.12.025

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Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis

Autor: Scott E. Plevy, Gregory R. Gipson, Jennifer K. Uno, Bo Liu, Steven M. Russo, Samantha T. Kennedy, Taku Kobayashi, Hans H Herfarth, Luke B. Borst, R. Balfour Sartor, Yoshiyuki Mishima, Jenny P.-Y. Ting, Shehzad Z. Sheikh, Erin C. Steinbach

The p110δ subunit of class IA PI3K modulates signaling in innate immune cells. We previously demonstrated that mice harboring a kinase-dead p110δ subunit (p110δKD) develop spontaneous colitis. Macrophages contributed to the Th1/Th17 cytokine bias

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09890924ec1bd91395d628bb70e422c5
https://europepmc.org/articles/PMC3992276/

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NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis

Autor: Paul B. Rothman, Scott E. Plevy, Luke B. Borst, J. Victor Garcia-Martinez, Bruce S. Hostager, Steven M. Russo, Taku Kobayashi, Shehzad Z. Sheikh, Nitsan Maharshak, Katsuyoshi Matsuoka, Erin C. Steinbach, Masaki Kashiwada, Peter J. Murray, Tomonori Nochi

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 192(4)

NFIL3 is a transcription factor that regulates multiple immunologic functions. In myeloid cells, NFIL3 is IL-10 inducible and has a key role as a repressor of IL-12p40 transcription. NFIL3 is a susceptibility gene for the human inflammatory bowel dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cea95f819a4c0ec737d04aadebe6ece
https://pubmed.ncbi.nlm.nih.gov/24442434

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In vitro and in vivo evaluation of a water-in-oil microemulsion system for enhanced peptide intestinal delivery

Autor: Dongyun Liu, Scott E. Plevy, Todd M. Gambling, Steven M. Russo, Fengling Li, Taku Kobayashi, Russell J. Mumper, Johnny L. Carson

Publikováno v: The AAPS journal. 15(1)

Peptide and protein drugs have become the new generation of therapeutics, yet most of them are only available as injections, and reports on oral local intestinal delivery of peptides and proteins are quite limited. The aim of this work was to develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0df57f5b3ff31a9b1a21d2022aea458
https://pubmed.ncbi.nlm.nih.gov/23196806

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IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis

Autor: R. Balfour Sartor, Katsuyoshi Matsuoka, Christopher L. Karp, Colm B. Collins, Scott E. Plevy, Yoshiyuki Mishima, Jenny P.-Y. Ting, Edwin F. deZoeten, Shehzad Z. Sheikh, Steven M. Russo, Taku Kobayashi

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 189(4)

To prevent excessive inflammatory responses to commensal microbes, intestinal macrophages, unlike their systemic counterparts, do not produce inflammatory cytokines in response to enteric bacteria. Consequently, loss of macrophage tolerance to the en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ec72a72ec6748f939a2eb8dde7b216
https://pubmed.ncbi.nlm.nih.gov/22786766

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