Výsledky vyhledávání - "Steven M. Pomeroy"

Akademický článek

Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery

Autor: Dhruvitkumar S. Sutaria, Jinmai Jiang, Ola A. Elgamal, Steven M. Pomeroy, Mohamed Badawi, Xiaohua Zhu, Ryan Pavlovicz, Ana Clara P. Azevedo-Pouly, Jeffrey Chalmers, Chenglong Li, Mitch A. Phelps, Thomas D. Schmittgen

Publikováno v: Journal of Extracellular Vesicles, Vol 6, Iss 1 (2017)

Extracellular vesicles (EVs) hold great potential as novel systems for nucleic acid delivery due to their natural composition. Our goal was to load EVs with microRNA that are synthesized by the cells that produce the EVs. HEK293T cells were engineere

Externí odkaz: https://doaj.org/article/7c22fd9364884b21810f63bf8ad71308

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Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells

Autor: Thomas D. Schmittgen, Jeffrey J. Chalmers, Ola A. Elgamal, Mohamed Badawi, Jinmai Jiang, Xiaokui Mo, Mitch A. Phelps, Alice Baek, Steven M. Pomeroy, Krista M. D. La Perle, Xiaohua Zhu, Dhruvitkumar S. Sutaria, Zhiliang Xie

Publikováno v: Journal of Extracellular Vesicles
Journal of Extracellular Vesicles, Vol 6, Iss 1 (2017)

Extracellular vesicles (EVs) are under evaluation as therapeutics or as vehicles for drug delivery. Preclinical studies of EVs often use mice or other animal models to assess efficacy and disposition. However, as most EVs under evaluation are derived

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c15bf3c3caa8cc99c2c9d4d6adf7e9b
http://europepmc.org/articles/PMC5505007

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Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery

Autor: Dhruvitkumar S. Sutaria, Xiaohua Zhu, Ana Clara P. Azevedo-Pouly, Jinmai Jiang, Steven M. Pomeroy, Ola A. Elgamal, Jeffrey J. Chalmers, Mohamed Badawi, Chenglong Li, Thomas D. Schmittgen, Mitch A. Phelps, Ryan E. Pavlovicz

Publikováno v: Journal of Extracellular Vesicles
Journal of Extracellular Vesicles, Vol 6, Iss 1 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338678a48cf5d790a5e56932143f8bc0
https://pubmed.ncbi.nlm.nih.gov/28717424

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Increased Replication of Non-Syncytium-Inducing HIV Type 1 Isolates in Monocyte-Derived Macrophages Is Linked to Advanced Disease in Infected Children

Autor: Keith W.C. Peden, Susanna L. Lamers, Daniel L. Tuttle, Paul P. Poole, Daniel R. Briggs, Steven M. Pomeroy, Maureen M. Goodenow, Cynthia Anders, Warren A. Andiman, John W. Sleasman, M. Janette Aquino-de Jesus, Louis Alexander

Publikováno v: AIDS Research and Human Retroviruses. 18:353-362

Non-syncytium-inducing (NSI) strains of HIV-1 prevail among most infected children, including pediatric patients who develop advanced disease, severe immune suppression, and die. A study was designed to address the hypothesis that genotypic and/or ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1d342bc637a97a6d1be6a8b5a8fc16
https://doi.org/10.1089/088922202753519133

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Human immunodeficiency virus type 1 long terminal repeat quasispecies differ in basal transcription and nuclear factor recruitment in human glial cells and lymphocytes

Autor: Brian Wigdahl, Maureen M. Goodenow, Fred C. Krebs, Steven M. Pomeroy, Dorothy Mehrens

Publikováno v: Journal of Biomedical Science. 5:31-44

The generation of genomic diversity during the course of infection has the potential to affect all aspects of HIV-1 replication, including expression of the proviral genome. To gain a better understanding of the impact of long terminal repeat (LTR) s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe381dc83eaec9870ad64ae101d9f4f7
https://doi.org/10.1007/bf02253354

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Persistence of multiple maternal genotypes of human immunodeficiency virus type I in infants infected by vertical transmission

Autor: Susanna L. Lamers, Jin-Xiong She, Maureen M. Goodenow, Steven M. Pomeroy, Douglas J. Barrett, John W. Sleasman, Kimberly A. Barrie

Publikováno v: Journal of Clinical Investigation. 93:380-390

The extent of nucleotide variation within the HIV-1 env hypervariable domains serves as a marker of virus genotypes within infected individuals and as a means to track transmission of the virus between individuals. We analyzed env V1 and V2 sequences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9773b8b7daa67a0031d2a97f2446bc
https://doi.org/10.1172/jci116970

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Neuroglial-specific factors and the regulation of retrovirus transcription

Autor: Renee Wessner, Maribeth Tillmann, Brian Wigdahl, Fred C. Krebs, Maureen M. Goodenow, Steven M. Pomeroy

Publikováno v: Advances in neuroimmunology. 4(3)

Retroviruses have been implicated as causative agents of a variety of human diseases including malignancy, immune system dysfunction, and neurologic disorders. Despite the isolation of various retroviral agents from patients suffering from malignant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2ff3807efe1b0b0b0999ed520dadbf
https://pubmed.ncbi.nlm.nih.gov/7874399

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