Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Steven M. Offer"'
Autor:
Jonathan E. Knikman, Qinglian Zhai, Carin A. T. C. Lunenburg, Linda M. Henricks, Stefan Böhringer, Maaike van der Lee, Femke M. de Man, Steven M. Offer, Shikshya Shrestha, Geert-Jan Creemers, Arnold Baars, Vincent O. Dezentjé, Alexander L. T. Imholz, Frank J. F. Jeurissen, Johanna E. A. Portielje, Rob L. H. Jansen, Paul Hamberg, Helga J. Droogendijk, Miriam Koopman, Peter Nieboer, Marlène H. W. van de Poel, Caroline M. P. W. Mandigers, Ron H. N. van Schaik, Hans Gelderblom, Ron H. J. Mathijssen, Jan H. M. Schellens, Annemieke Cats, Henk-Jan Guchelaar, Jesse J. Swen
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background The Alpe-DPD study (NCT02324452) demonstrated that prospective genotyping and dose-individualization using four alleles in DPYD (DPYD*2A/rs3918290, c.1236G > A/rs75017182, c.2846A > T/rs67376798 and c.1679 T > G/rs56038477) can mi
Externí odkaz:
https://doaj.org/article/b16be71c28a348628ff01bad41681526
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 4, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/5b86d78c843c43108c539809f2da76de
Autor:
Saba Ghaffari, Kelly J. Bouchonville, Ehsan Saleh, Remington E. Schmidt, Steven M. Offer, Saurabh Sinha
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-30 (2023)
Abstract Differential gene expression in bulk transcriptomics data can reflect change of transcript abundance within a cell type and/or change in the proportions of cell types. Expression deconvolution methods can help differentiate these scenarios.
Externí odkaz:
https://doaj.org/article/03e0730ee6a04e93954e796d6de17b86
Autor:
Alisa Ambrodji, Angélique Sadlon, Ursula Amstutz, Dennis Hoch, Martin D. Berger, Sara Bastian, Steven M. Offer, Carlo R. Largiadèr
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7599 (2024)
Pre-treatment genotyping of four well-characterized toxicity risk-variants in the dihydropyrimidine dehydrogenase gene (DPYD) has been widely implemented in Europe to prevent serious adverse effects in cancer patients treated with fluoropyrimidines.
Externí odkaz:
https://doaj.org/article/ce0598a69e0643af8b35f34578e4afc4
Autor:
Amy J. Turner, Cyrine E. Haidar, Wenjian Yang, Erin C. Boone, Steven M. Offer, Philip E. Empey, Andrew Haddad, Saba Tahir, Gunter Scharer, Ulrich Broeckel, Andrea Gaedigk
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 1, Pp n/a-n/a (2024)
Abstract The DPYD gene encodes dihydropyrimidine dehydrogenase, the rate‐limiting enzyme for the metabolism of fluoropyrimidines 5‐fluorouracil and capecitabine. Genetic variants in DPYD have been associated with altered enzyme activity, therefor
Externí odkaz:
https://doaj.org/article/5ba0596362e44f6ea49932ac67879e47
Autor:
Xinran Li, Jiaqi Zhou, Wenjuan Zhao, Qing Wen, Weijie Wang, Huipai Peng, Yuan Gao, Kelly J. Bouchonville, Steven M. Offer, Kuiming Chan, Zhiquan Wang, Nan Li, Haiyun Gan
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 1, Pp 87-100 (2022)
Proximity labeling catalyzed by promiscuous enzymes, such as APEX2, has emerged as a powerful approach to characterize multiprotein complexes and protein–protein interactions. However, current methods depend on the expression of exogenous fusion pr
Externí odkaz:
https://doaj.org/article/644a5eceee4a410299fef3ebf625378f
Publikováno v:
Journal of the National Cancer Center, Vol 1, Iss 1, Pp 15-22 (2021)
The long-term effectiveness of targeted cancer therapies is limited by the development of resistance. Although epigenetic reprogramming has been implicated in resistance, the mechanisms remain elusive. Herein, we demonstrate that increased chromatin
Externí odkaz:
https://doaj.org/article/accd85a0450f4044aac0532324b3811d
Autor:
Saba Ghaffari, Casey Hanson, Remington E. Schmidt, Kelly J. Bouchonville, Steven M. Offer, Saurabh Sinha
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-28 (2021)
Abstract Background Metastatic progress is the primary cause of death in most cancers, yet the regulatory dynamics driving the cellular changes necessary for metastasis remain poorly understood. Multi-omics approaches hold great promise for addressin
Externí odkaz:
https://doaj.org/article/3b06df1e6d194294a86ab1748ec3cb2c
Autor:
Jason A. Sprowl, Su Sien Ong, Alice A. Gibson, Shuiying Hu, Guoqing Du, Wenwei Lin, Lie Li, Shashank Bharill, Rachel A. Ness, Adrian Stecula, Steven M. Offer, Robert B. Diasio, Anne T. Nies, Matthias Schwab, Guido Cavaletti, Eberhard Schlatter, Giuliano Ciarimboli, Jan H. M. Schellens, Ehud Y. Isacoff, Andrej Sali, Taosheng Chen, Sharyn D. Baker, Alex Sparreboom, Navjotsingh Pabla
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Organic cation transporters are important drug transporters that influence therapeutic outcomes. Here, the authors find that these transporters are regulated by tyrosine phosphorylation and propose that tyrosine kinase inhibitors can influence drug t
Externí odkaz:
https://doaj.org/article/e23f1634f35944d0a0ca31c8bfbcf90b
Autor:
Robert B. Diasio, Steven M. Offer
Publikováno v:
Holland‐Frei Cancer Medicine. :1-13